Functional Neurobiology of Aging

Contributors.<br>Foreword.<br>Preface.<br>Overview:<br>Introduction to Concepts in Aging Research:<br>Age-Specific Rates of Neurological Disease, J.E. Riggs.<br>Nature versus Nurture in the Aging Brain, C.V. Mobbs and J.W. Rowe.<br>Neurochemistry of Receptor Dynamics in the Aging Brain, B.J. Keck and J.M. Lakoski.<br>Epidemiology of Neural Aging:<br>Demography and Epidemiology of Age-Associated Neuronal Impairment, C.K. Cassel and K. Ek.<br>Memory: Neocortical and Hippocampal Functions:<br>Neuropsychology of Human Aging.<br>Memory Changes with Aging and Dementia, P.D. Harvey and R.C. Mohs.<br>Histology of Age-Related Cortical Changes in Humans:<br>Types of Age-Related Brain Lesions and Relationship to Neuropathological Diagnostic Systems of Alzheimer's Disease, P. Giannakopoulos, E. Kövari, G. Gold, P.R. Hof, and C. Bouras.<br>Morphological changes in Human Cerebral Cortex during Normal Aging, T. Bussière and P.R. Hof.<br>Longevity and Brain Aging: The Paradigm of Centenarians, C. Bouras, P.G. Vallet, E. Kövari, J.-P. Michel, F.R. Herrmann, P.R. Hof, and P. Giannakopoulos .<br>Alzheimer's Disease:<br>Regional and Laminar Patterns of Selective Neuronal Vulnerability in Alzheimer's Disease, P.R. Hof.<br>Patterns of Cortical Neurodegeneration in Alzheimer's Disease: Subgroups, Subtypes, and Implications for Staging Strategies, B.A. Vogt, L.J. Vogt, and P.R. Hof.<br>Non-Alzheimer Age-Associated Dementing Disorders:<br>Vascular Dementia, G. Gold, C. Bouras, J.-P. Michel, P.R. Hof, and P. Giannakopoulos.<br>Frontotemporal Dementias: From Classification Problems to Pathogenetic Uncertainties, P. Giannakopoulos, E. Kövari, G. Gold, P.R. Hof and C. Bouras.<br>Progressive Supranuclear Palsy and Corticobasal Degeneration, D.W. Dickson.<br>Neurobiology of Disorders with Lewy Bodies, L. Hansen and E. Masliah.<br>Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of Guam, D.P. Perl.<br>In Vivo Imaging of Aging Brain:<br>Brain Energy Metabolism: Cellular Aspects and Relevance to Functional Brain Imaging, P.J. Magistretti, S. Joray, and L. Pellerin.<br>Functional Imaging in Cognitively Intact Aged People, N.D. Anderson and C.L. Grady.<br>Functional Brain Studies of the Neurometabolic Bases of Cognitive and Behavioral Changes in Alzheimer's Disease, P. Pietrini, M.L. Furey, M. Guazzelli, and G.E. Alexander.<br>Biochemical Correlates of Memory Impairments:<br>Cholinergic Basal Forebrain Systems in the Primate Central Nervous System: Anatomy, Connectivity, Neurochemistry, Aging, Dementia, and Experimental Therapeutics, E.J. Mufson and J.H. Kordower.<br>Glutamate Receptors in Aging and Alzheimer's Disease, A. Mishizen, M. Ikonomovic, and D.M. Armstrong.<br>Tau Phosphorylation, L. Buée and A. Delacourte.<br>Hereditary Basis of Alzheimer's Disease and Related Dementias:<br>Etiology, Genetics, and Pathogenesis of Alzheimer's Disease, C. McKeon-O'Malley and R. Tanzi.<br>Nonhereditary Mechanisms of Alzheimer's Disease:<br>Inflammation, Free Radicals, Glycation, Metabolism and Apoptosis, and Heavy Metals, M.P. Mattson.<br>Rodent Models of Age-Related Memory Impairments:<br>Rodent Models of Age-Related Memory Impairments, D.K. Ingram.<br>Genetically Engineered Models of Human Age-Related Neurogenerative Diseases, J.C. Vickers.<br>Nonhuman Primate and Other Vertebrate Models of Brain Aging:<br>Cognitive Aging in Nonhuman Primates, M.G. Baxter.<br>Brain Aging in Strepsirhine Primates, E.P. Gilissen, M. Dhenain, and J.M. Allman.<br>Age-Related Morphologic Alterations in the Brain of Old World and New World Anthropoid Monkeys, P.R. Hof and H. Duan.<br>The Study of Brain Aging in Great Apes, J.M. Erwin, E.A. Nimchinsky, P.J. Gannon, D.P. Perl, and P.R. Hof.<br>Neurobiological Models of Aging in the Dog and Other Vertebrate Species, E. Head, N.W. Milgram, and C.W. Cotman.<br>Interventions:<br>Estrogens and Alzheimer's Disease, N.D. Tsopelas and D.B. Marin.<br>Cholinergic Treatments of Alzheimer's Disease, N.D. Tsopelas and D.B. Marin.<br>Anti-Inflammatory and Antioxidant Therapies in Alzheimer's Disease, P.S. Aisen and G.M. Pasinetti.<br>Senses: Sensory Cortices and Primary Afferent Functions:<br>Vision:<br>The Retina in Aging and in Alzheimer's Disease, R.O. Kuljis.<br>Pathogenesis of Glaucomatous Optic Neuropathy, M.R. Hernandez and A.H. Neufeld.<br>Color Vision, Object Recognition, and Spatial Localization in Aging and Alzheimer's Disease, A. Cronin-Golomb.<br>Hearing:<br>Anatomical and Neurochemical Bases of Presbycusis, R.D. Frisina, Jr..<br>Age, Noise, and Ototoxic Agents, R.J. Salvi, D. Ding, A.C. Eddins, S.L. McFadden, and D. Henderson.<br>Auditory Temporal Processing during Aging, D.R. Frisinia, R.D. Frisinia, Jr., K.B. Snell, R. Burkard, J.P. Walton, and J.R. Ison.<br>Neurophysiological Manifestations of Aging in the Peripheral and Central Auditory Nervous System, J.P. Walton and R. Burkard.<br>Genetics and Age-Related Hearing Loss, S.L. McFadden.<br>Animal Models of Presbycusis and the Aging Auditory System, J.F. Willott.<br>The Development of Animal Models for the Study of Presbycusis: Building a Behavioral Link between Perception and Physiology, J.R. Ison.<br>Rehabilitation for Presbycusis, D.G. Sims and R. Burkard.<br>Chemical Senses:<br>Olfaction and Gustation in Normal Aging and Alzheimer's Disease, R.L. Doty.<br>Locomotion: Basal Ganglia and Muscular Functions:<br>Functional Impairments in Humans:<br>Aging Effects on Muscle Properties and Human Performance, S.A. Jubrias and K.E. Conley.<br>Parkinson's Disease: Symptoms and Age Dependency, S.A. Eshuis and K.L. Leenders.<br>Pathology and Biochemistry of Aging and Disease of Basal Ganglia:<br>The Basal Ganglia Dopaminergic Systems in Normal Aging and Parkinson's Disease, J.N. Joyce.<br>Huntington's Disease, S.E. Browne and M.F. Beal.<br>Animal Models:<br>Biochemical and Anatomical Changes in Basal Ganglia of Aging Animals, J.A. Stanford, M.A. Hebert, and G.A. Gerhardt.<br>Homeostasis: Hypothalamus and Related Systems:<br>Reproduction and the Aging Brain:<br>Male Sexual Behavior during Aging, H. Kuno, M. Godschalk, and T. Mulligan.<br>Sexual Behavior in Aging Women, N.E. Avis.<br>Factors Influencing the Onset of Female Reproductive Senescence, P.S. LaPolt and J.K.H. Lu.<br>Female Sexuality during Aging, N.L. McCoy.<br>Hypothalamic Neuropeptide Gene Expression in Postmenopausal Women, N.E. Rance and T.W. Abel.<br>Neuroendocrine Aspects of Female Reproductive Aging, P.M. Wise and M.J. Smith.<br>Hypothalamic Changes Relevant to Reproduction in Aging Male Rodents, D.A. Gruenewald and A.M. Matsumoto.<br>Metabolism and the Aging Brain:<br>Regulation of Energy Intake in Old Age, S.B. Roberts and N.P. Hays.<br>Thermoregulation during Aging, B.A. Horwitz, A.M. Gabaldón, and R.B. McDonald.<br>Biological Rhythms and the Aging Brain:<br>Sleep and Hormonal Rhythms in Humans, G. Copinschi, R. Leproult, and E. Van Cauter.<br>Circadian Rhythms and Sleep in Aging Rodents, D.E. Kolker and F.W. Turek.<br>Glucocorticoid Secretion and the Aging Brain:<br>Clucocorticoids and the Aging Brain: Cause or Consequence?<br>P.J. Lucassen and E.R. De Kloet.<br>Growth Hormone, Insulin-like Growth Factor-1, and the Aging Brain, P.L. Thornton and W.E. Sonntag.<br>Automatic Nervous System and the Aging Brain:<br>The Aged Sympathetic Nervous System, G.A. Kuchel and T. Cowen.<br>Appendix.<br>Basic Genetic Concepts.