Section I: Technological Fundamentals<br><br>Chapter 1 Medical Imaging<br>Dr. Xiaofeng Zhang, Dr. Nadine Smith and Prof. Andrew Webb<br><br>1.1 Introduction<br>1.2 Digital radiography<br>1.3 Computed tomography<br>1.4 Nuclear medicine<br>1.5 Ultrasonic imaging<br>1.6 Magnetic resonance imaging<br>1.7 Diffuse optical imaging<br>1.8 Biosignals<br>1.9 Appendix<br>1.10 Exercises<br>1.11 Bibliography<br>1.12 Index<br><br>Chapter 2 Electronic Medical Record (EMR)<br><br>Dr. Eugene,Y. S. Lim, Prof. Michael Fulham and Prof. David Dagan Feng<br><br>2.1 Introduction<br>2.2 Medical data and patient record<br>2.3 Terminology standards – vocabulary and a clinical coding system1<br>2.4 Information exchange standards<br>2.5 Usability issues in EMR<br>2.6 User interface<br>2.7 Evaluation<br>2.8 EMR system – a case study: a web-based imaging electronic patient history<br>2.9 Summary<br>2.10 Exercise<br>2.11 Bibliography and references<br>2.12 Index<br><br>Chapter 3 Image Data Compression and Storage<br><br>Prof. Hong Ren Wu, Dr. Damian M. Tan, Dr. Tom Weidong Cai and Prof. David Dagan Feng <br><br>3.1 Introduction<br>3.2 Picture compression<br>3.3 Compression in the dicom standard<br>3.4 Data compression for dynamic functional images<br>3.5 Summary<br>3.6 Exercises<br>3.7 References<br>3.8 Index<br><br><br>Chapter 4 Content-Based Medical Image Retrieval<br><br>Dr. Tom Weidong Cai, Dr. Jinman Kim and Prof. David Dagan Feng<br><br>4.1 Introduction<br>4.2 CBMIR by physical visual features<br>4.3 CBMIR by geometric spatial features<br>4.4 CBMIR by combination of semantic and visual features<br>4.5 CBMIR by physiological functional features<br>4.6 Summary<br>4.7 Exercises<br>4.8 Bibliography and references<br>4.9 Index<br><br>Chapter 5 Data Modeling and Simulation<br><br>Dr. Alessandra Bertoldo, Prof. Claudio Cobelli<br><br>5.1 Introduction<br>5.2 Compartmental models<br>5.3 Model identification<br>5.4 Model validation<br>5.5 Simulation<br>5.6 Case study<br>5.7 Quantification of medical images<br>5.8 Exercises<br>5.9 Bibliography and references<br><br>Chapter 6 Techniques for Parametric Imaging<br><br>Prof. David Dagan Feng, Dr. Lingfeng Wen and Dr. Stefan Eberl<br><br>6.1 Introduction<br>6.2 Parametric image estimation methods<br>6.3 Noninvasive methods<br>6.4 Clinical applications of parametric images<br>6.5 Summary<br>6.6 Exercise<br>6.7 Bibliography and references<br>6.8 Index<br><br>Chapter 7 Data Processing and Analysis<br><br>Prof. Chris Wyatt, Prof. Yu-Ping Wang, Prof. Matthew T. Freedman, Prof. Murray Loew and Prof. Yue Wang<br><br>7.1 Introduction<br>7.2 Medical image enhancement<br>7.3 Medical image segmentation<br>7.4 Medical image feature extraction<br>7.5 Medical image interpretation<br>7.6 Summary<br>7.7 Exercises<br>7.8 Bibliography<br>7.9 Index<br><br>Chapter 8 Data Registration and Fusion<br><br>Dr. Xiu Ying Wang, Dr. Stefan Eberl, Prof. Michael Fulham, Dr. Seu Som and Prof. David Dagan Feng<br><br><br>8.1 Introduction<br>8.2 Fundamentals of biomedical image registration and fusion<br>8.3 Feature-based medical image registration<br>8.4 Intensity-based registration<br>8.5 Hybrid registration and hierarchical registration<br>8.6 Hardware registration<br>8.7 Assessment of registration accuracy<br>8.8 Applications of biomedical image registration and fusion<br>8.9 Summary<br>8.10 Exercises<br>8.11 Bibliography and references<br>8.12 Index<br><br>Chapter 9 Data Visualization and Display<br>Dr. Jinman Kim, Dr. Tom Weidong Cai, Prof. Michael Fulham, Dr. Stefan Eberl and Prof. David Dagan Feng<br><br>9.1 Introduction<br>9.2 Two-Dimensional (2D) visualization techniques<br>9.3 Three-Dimensional (3D) visualization techniques<br>9.4 Volume navigation interface<br>9.5 Volume enhancement and manipulation<br>9.6 Large data visualization and optimization<br>9.7 Dual-modality PET/CT visualization<br>9.8 Data display devices<br>9.9 Applications of biomedical visualization<br>9.10 Summary<br>9.11 Exercises<br>9.12 Bibliography and references<br>9.13 Index<br><br>Chapter 10 Data Communication and Network Infrastructue<br><br>Prof. Doan B. Hoang and Dr. Andrew J. Simmonds<br><br>10.1 Introduction<br>10.2 Transmission and communication technologies<br>10.3 The internet and World Wide Web<br>10.4 Wireless and mobile technologies in m-health<br>10.5 Sensor networks for health monitoring<br>10.6 Applications of wireless technologies in telemedicine<br>10.7 Summary<br>10.8 Exercises<br>10.9 Bibliography and references<br>10.10 Index<br><br>Chapter 11 Data Security and Protection for Medical Images<br><br>Dr. Eugene, Y. S. Lim <br><br>11.1 Introduction<br>11.2 Overview of cryptographic system<br>11.3 Digital watermarking<br>11.4 Medical image watermarking<br>11.5 Region-based reversible watermarking for secure pet image management<br>11.6 Summary<br>11.7 Exercise<br>11.8 Bibliography<br>11.8 Index<br><br>Chapter 12 Biological Computing<br><br>Prof. Eric P Hoffman, Erica Reeves, Dr. Yetrib Hathout, Dr. Zuyi Wang and <br>Josephine Chen<br><br>12.1 Introduction<br>12.2 Overview of genomic methods<br>12.3 Overview of proteomic methods<br>12.4 Bioinformatics and information infrastructure<br>12.5 Data mining and large-scale biological databases<br>12.6 Biological event-driven, time-driven and hybrid simulation techniques<br>12.7 Summary<br>12.8 Bibliography<br> <br><br>Section II: Integrated Applications<br><br>Chapter 13 PACS and Medical Imaging Informatics (MII) for Filmless Hospitals<br><br>Prof. Brent J. Liu and Prof. H.K. Huang<br><br>13.1 Introduction<br>13.2 PACS infrastructure<br>13.3 PACS components and workflow<br>13.4 PACS controller and image archive<br>13.5 Large-scale PACS implementation<br>13.6 PACS clinical experiences<br>13.7 Summary<br>13.8 Exercises<br>13.9 Bibliography and references<br>13.9 Index<br><br>Chapter 14 KMeX: A Knowledge-Based Digital Library for Retrieving Scenario-Specific Medical Text Documents<br>Prof. Wesley W. Chu, Dr. Zhenyu Liu, Dr. Wenlei Mao and Dr. Qinghua Zou<br><br>14.1 Introduction<br>14.2 Extracting key concepts from documents<br>14.3 Transforming similar queries into query templates<br>14.4 Topic-oriented directory<br>14.5 Phrase-based vector space model for automatic document retrieval<br>14.6 Knowledge-based scenario-specific query expansion<br>14.7 A system architecture for retrieving scenario-specific free text documents<br>14.8 Summary<br>14.9 Exercises<br>14.10 Bibliography<br><br>Chapter 15 Integrated Multimedia Patient Record Systems<br>Dr. Ruth E. Dayhoff, Mr. Peter M. Kuzmak and Mr. Kevin Meldrum<br><br>15.1 Introduction<br>15.2 Multimedia patient record<br>15.3 Multimedia patient record system architecture components<br>15.4 Electronic medical chart components<br>15.5 Objects comprising the multimedia patient record<br>15.6 Capturing multimedia data at the source<br>15.7 DICOM image acquisition<br>15.8 Remote data and image viewing across the healthcare network<br>15.9 Impact on patient care<br>15.10 Summary<br>15.11 References<br><br>Chapter 16 Computer-Aided Diagnosis (CAD)<br>Prof. Maryellen L. Giger and Dr. Kenji Suzuki<br><br>16.1 Introduction<br>16.2 CAD<br>16.3 CAD for cancer screening<br>16.4 CAD for differential diagnosis<br>16.5 Intelligent CAD workstations – indices of similarity and human/computer interfaces<br>16.6 Summary<br>16.7 Exercises<br>16.8 Bibliography<br>16.9 Index<br><br>Chapter 17 Clinical Decision Support Systems (CDSS)<br><br>Dr. Peter Weller, Dr. Abdul Roudsari and Prof. Ewart Carson<br><br>17.1 Introduction<br>17.2 Overview of CDSS<br>17.3 Human diagnostic reasoning<br>17.4 A structure for characterising CDSS<br>17.5 Decision support tools<br>17.6 Decision support systems in the hospital and other healthcare settings<br>17.7 Healthcare education applications<br>17.8 Verification, validation and evaluation<br>17.9 Summary<br>17.10 Exercises<br>17.11 References<br>17.12 Index<br><br>Chapter 18 Medical Robotics and Computer-Integrated Interventional Medicine<br><br>Prof. Russell H. Taylor and Dr. Peter Kazanzides<br><br>18.1 Introduction<br>18.2 Technology & Techniques<br>18.3 Surgical CAD/CAM<br>18.4 Surgical Assistance<br>18.5 Summary and conclusion<br>18.6 Exercises<br>18.7 References<br>18.8 Index<br><br>Chapter 19 Functional Techniques for Brain Magnetic Resonance Imaging<br>Dr. Sirong Chen, Dr. Kai-Ming Au Yeung and Dr. Gladys Goh Lo<br><br>19.1 Introduction<br>19.2 Diffusion-weighted MR imaging in brain<br>19.3 MR perfusion imaging in brain<br>19.4 Functional MRI (fMRI) using bold techniques<br>19.5 Clinical MR spectroscopy in brain<br>19.6 Summary<br>19.7 Exercises<br>19.8 Bibliography and references<br>19.9 Index<br><br>Chapter 20 Molecular Imaging in Cancer<br>Prof. Kristine Glunde, Dr. Catherine A. Foss and Prof. Zaver M. Bhujwalla<br> <br>20.1 Introduction<br>20.2 Imaging of gene expression<br>20.3 Receptor imaging<br>20.4 Enzyme-activated probes<br>20.5 Metabolic imaging<br>20.6 Imaging of permeability, perfusion, and blood flow<br>20.7 Imaging of the tumor microenvironment<br>20.8 Multimodality imaging<br>20.9 Conclusion<br>20.10 Exercises<br>20.11 References<br>20.12 Index<br><br>Chapter 21 Molecular Imaging in Biology and Pharmacology<br>Prof. Sung-Cheng Huang, Prof. Anna M. Wu and Prof. Jorge R. Barrio<br><br>21.1 Introduction and background<br>21.2 Considerations for quantitative molecular imaging<br>21.3 Design/development of molecular imaging probes<br>21.4 Molecular imaging of beta-amyloid and NFT<br>21.5 Molecular imaging using antibody probes<br>21.6 Some other molecular imaging applications<br>21.7 Summary and future perspectives<br>21.8 Exercises<br>21.9 References<br>21.10 Index<br><br>Chapter 22 From Telemedicine to Ubiquitous M-Health: the Evolution of E Health Systems<br><br>Dr. Dejan Raškoviæ, Dr. Aleksandar Milenkoviæ, Prof. Piet C. De Groen and<br>Dr. Emil Jovanov<br><br>22.1 Introduction<br>22.2 Overview of m-health systems<br>22.3 M-health based on Wireless Body Area Networks (WBAN)<br>22.4 Wireless intelligent sensors for m-health<br>22.5 Wireless mobile devices for m-health<br>22.6 Next-generation m-health systems<br>22.7 Summary<br>22.8 Exercises<br>22.9 References<br>22.10 Index<br><br>Chapter 23 Multimedia for Future Health – Smart Medical Home………………1<br><br>Dr. Jinman Kim, Dr. Zhiyong Wang, Dr. Tom Weidong Cai and Prof. David Dagan Feng<br><br>23.1 Introduction<br>23.2 Multimedia for human-computer interaction<br>23.3 Multimedia content management<br>23.4 Multimedia delivery<br>23.5 Smart medical home<br>23.6 Telemedicine in the smart medical home<br>23.7 Sensory devices and health monitoring<br>23.8 Speech recognition and conversational systems<br>23.9 Multimedia technologies for patient education and care<br>23.10 Multimedia operating theater and Virtual Reality (VR)<br>23.11 Summary<br>23.12 Exercises<br>23.13 References<br>23.15 Index