<p>1. Discovery and Development of Calcimimetic and Calcilytic Compounds<br>Edward F. Nemeth, Bradford C. Van Wagenen and Manuel F. Balandrin<br>2. VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine)<br>Nicole D. Harriott, John P. Williams, Evan B. Smith, Haig P. Bozigian and Dimitri E. Grigoriadis<br>3. Current Trends in Macrocyclic Drug Discovery and Beyond-Ro5<br>Sulejman Alihodzic, Mirjana Bukvic, Ivaylo J. Elenkov, Antun Hutinec, Sanja Koštrun, Dijana Pesic, Gordon Saxty, Linda Tomaškovic and Dinko Ziher<br>4. Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR<br>Phil R. Kym, Xueqing Wang, Mathieu Pizzonero and Steven E. Van der Plas<br>5. Big Data in Drug Discovery<br>Nathan Brown, Jean Cambruzzi, Peter J. Cox, Mark Davies, James Dunbar, Dean Plumbley, Matthew A. Sellwood, Aaron Sim, Bryn I. Williams-Jones, Magdalena Zwierzyna and David W. Sheppard</p>