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Biomarkers for Traumatic Brain Injury

Specificaties
Paperback, blz. | Engels
Elsevier Science | 2020
ISBN13: 9780128163467
Rubricering
Elsevier Science e druk, 2020 9780128163467
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Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers.

Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities.

Specificaties

ISBN13:9780128163467
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

Section I. INTRODUCTION<br>1. Introduction—scope of the problem<br>2. The need for traumatic brain injury markers<br>3. Regulatory considerations for diagnostics and biomarkers of traumatic brain injury <br>Section II. PATHOPHYSIOLOGY OF TBI<br>4. Peripheral markers of TBI and blood-brain barrier disruption<br>5. The role of autoimmunity after traumatic brain injury<br>6. Traumatic brain injury: glial fibrillary acidic protein posttranslational<br>modification<br>SECTION III. TBI BIOMARKERS IN MEDICAL PRACTICE<br>7. Economics of traumatic brain injury biomarkers<br>8. Electrophysiology monitoring<br>9. Traumatic brain injury therapeutics<br>SECTION IV. CLASSICAL TBI BIOMARKERS<br>10. S100 biomarkers in patients with traumatic brain injury<br>11. Pathophysiology and clinical implementation of traumatic brain injury biomarkers: neuron-specific enolase<br>12. Traumatic brain injury biomarkers glial fibrillary acidic protein/ubiquitin C-terminal hydrolase L1<br>13. Neurofilaments light chain/Neurofilaments heavy chain<br>14. Tau protein, biomarker for traumatic brain injury<br>SECTION V. NOVEL TBI BIOMARKERS<br>15. Neurogranin<br>16. Myelin basic protein in traumatic brain injury<br>SECTION VI. ANALYTICAL TESTING CONSIDERATION<br>17. Antibody selection, evaluation, and validation for analysis of traumatic brain injury biomarkers<br>18. Sensitive immunoassay testing platforms<br>19. Clinical mass spectrometry and its applications in traumatic brain injuries<br>20. Surface plasmon resonance<br>21. Point-of-care testing for concussion and traumatic brain injury<br>SECTION VII. NON-BLOOD TBI BIOMARKER STRATEGY<br>22. Clinical risk factors of traumatic brain injury<br>23. Saliva biomarkers of traumatic brain injury<br>24. Digital neurocognitive testing<br>25. Electroencephalographic as a biomarker of concussion <br>26. Neuropsychological testing<br>27. Outpatient risk stratification for traumatic brain injury<br>28. Peptidomics and traumatic brain injury: biomarker utilities for a theragnostic approach<br>29. Autoantibodies in central nervous system trauma: new frontiers for diagnosis and prognosis biomarkers
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        Biomarkers for Traumatic Brain Injury