Lahita's Systemic Lupus Erythematosus

Specificaties
Gebonden, blz. | Engels
Elsevier Science | 2021
ISBN13: 9780128205839
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Elsevier Science e druk, 2021 9780128205839
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Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission.

Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.

To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.

A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Specificaties

ISBN13:9780128205839
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>Part I: Basis of the Disease<br>Section A: Genetics and epigenetics<br>1. Major histocompatibility complex and SLE<br>2. Lupus Susceptibility genes<br>3. Epigenetics in systemic lupus erythematosus and the integration of molecular pathways</p> <p>Section B: Immunopathogenesis<br>4. Autoantigens, antigenic mimicry, and immune complexes<br>5. B-cell Biology, tolerance and autoantibodies<br>6. T-Cell Biology, tolerance and regulation<br>7. Polymorphonuclear cells<br>8. Metabolic and mitochondrial dysfunction in SLE<br>9. Immunopathogenesis: the role of mucosal and skin microbiota in SLE</p> <p>Section C: Disease effectors and modifiers<br>10. Complement and SLE<br>11. Interferons and cytokines in SLE pathogenesis and therapy<br>12. Innate immunity in SLE pathogenesis<br>13. Sex bias in SLE</p> <p>Section D: Tissue injury—the Biology<br>14. Mechanisms of tissue injury in lupus nephritis<br>15. The skin<br>16. The brain in SLE: mechanisms and detection of injury and therapeutic strategies<br>17. The role of infections in SLE pathogenesis<br>18. Tissue injurydthe biology: SLE-associated vascular disease and antiphospholipid syndrome</p> <p>Part II: Clinical presentation of disease<br>Section A: Clinical presentation<br>19. Epidemiology of SLE and related diseases: incidence, prevalence, and mortality<br>20. The clinical presentation of systemic lupus erythematosus and laboratory diagnosis<br>21. Passively acquired lupus in the fetus and neonate<br>22. Systemic lupus erythematosus in children<br>23. Environmental and drug-induced lupus<br>24. Reproductive health<br>25. Monitoring disease activity<br>26. Overlap syndromes</p> <p>Section B: Specific organ involvement and clinical presentation<br>27. Nervous system<br>28. Skin<br>29. Kidney disease<br>30. Cardiovascular disease in lupus<br>31. Pulmonary manifestations of systemic lupus erythematosus<br>32. GI hepatic and nonhepatic diseases<br>33. Musculoskeletal system: articular disease, myositis, and bone metabolism<br>34. Clinical presentation of antiphospholipid syndrome<br>35. Hematology: cytopenias<br>36. Malignancy risk and screening</p> <p>Section C: Treatment of systemic llupus erythematosus<br>37. Antimalarial drugs (and lupus)<br>38. Glucocorticoids<br>39. Immunosuppressive therapy in SLE<br>40. Pipeline therapies and future drug development<br>41. Challenges of systemic lupus clinical trials</p>
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        Lahita's Systemic Lupus Erythematosus