Epigenetics in Organ Specific Disorders

Specificaties
Paperback, blz. | Engels
Elsevier Science | 2022
ISBN13: 9780128239315
Rubricering
Elsevier Science e druk, 2022 9780128239315
Onderdeel van serie Translational Epigenetics
€ 185,80
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Samenvatting

**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**

Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.

Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.

Specificaties

ISBN13:9780128239315
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

1. Introduction to epigenetic mechanisms<br>2. Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells<br>3. Cell-cell and Cell-matrix interactions mediated by histone deacetylases<br>4. Enhanced cell proliferation and altered gene expression due to actions of DNA methyltransferases<br>5. Histone deacetylases and regulation of gene expression during cell proliferation<br>6. Epigenetic mediators that promote cytoskeletal reorganization and cell migration<br>7. Inhibition of cellular apoptosis and senescence by unique epigenetic proteins<br>8. Epigenetic mechanisms involved in the regulation of necrosis and pyknosis<br>9. Epigenetic control over cell division in pathological conditions<br>10. Regulated expression of tumor suppressor proteins by DNA methyltransferases during cell cycle progression<br>11. Role of histone deacetylases in regulating cell cycle progression<br>12. Phenotype switch and cell differentiation in immune and non-immune cells regulated by different epigenetic mediators<br>13. Epigenetic pathways that promote cellular autophagy<br>14. Epigenetic inducers of Cell growth and survival<br>15. Microbial compounds as potential inducers of epigenetic mechanisms during infections<br>16. Current epigenetic drugs and their target proteins with potential use in disease treatment<br>17. Prospects of epigenetic drugs in combination therapy
€ 185,80
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Rubrieken

    Personen

      Trefwoorden

        Epigenetics in Organ Specific Disorders