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Droplets of Life

Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation

Specificaties
Paperback, blz. | Engels
Elsevier Science | 2022
ISBN13: 9780128239674
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Elsevier Science e druk, 2022 9780128239674
€ 211,00
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Samenvatting

Droplets of Life: Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid–Liquid Phase Separation provides foundational information on the biophysics, biogenesis, structure, functions, and roles of membrane-less organelles. The study of liquid–liquid phase separation has attracted a lot of attention from disciplines such as cell biology, biophysics, biochemistry, and others trying to understand how, why, and what roles these condensates play in homeostasis and disease states in living organisms. This book's editor recruited a group of international experts to provide a current and authoritative overview of all aspects associated with this exciting area.

Sections introduce membrane-less organelles (MLOs) and biomolecular condensates; MLOs in different sizes, shapes, and composition; and the formation of MLOs due to phase separation and how it can tune reactions, organize the intracellular environment, and provide a role in cellular fitness..

Specificaties

ISBN13:9780128239674
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

Part I: Introduction to Membrane-less Organelles and Biomolecular Condensates<br>1. Biophysical Principles of Liquid-Liquid Phase Separation<br>2. Major Structural Features of MLOs<br>3. Multiphase Complex Droplets<br>4. Biogenesis of MLOs and Protein Condensates<br>5. Techniques for the Detection and Analysis of LLPS and MLOs<br>6. LLPS and Origin of Life<br><br>Part II: Biology of Membrane-Less Organelles<br>1. Known Types of Membrane-Less Organelles and Biomolecular Condensates<br>2. Active Regulation Mechanisms<br>3. Control of Metabolic Pathways<br>4. Interactions and Interplay with Classical Membrane-Bound Organelles<br>5. LLPS and Chromatin Organization<br>6. MLOs and Cellular Fitness<br>7. Cellular Stress<br>8. Phase Separation in Bacteria<br>9. Phase Separation and Virus Replication Compartments<br><br>Part III: Pathological roles of LLPS<br>1. Neurodegenerative Diseases<br>2. Cancer<br>3. Cardiovascular Diseases<br>4. Infectious Diseases
€ 211,00
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        Droplets of Life