Foreword<br>by Steve Edelman<br>Introduction and Preface<br>by Andre J Krentz<br>Section 1: Normal Physiology: Insulin Secretion and Insulin Action<br><br>1. Insulin Biosynthesis and Release<br>by Gabriela da Silva Xavier<br> <br>2. Classic Metabolic Actions of Insulin in Humans<br>by Andrew J Krentz<br> <br>3. Non-classic Effects of Insulin<br>by George King<br><br>Section 2a: Role of Insulin in Human Disease<br><br>4. Type 1 Diabetes Pathogenesis: Lessons Learned and Questions that Remain<br>by Adebola Matthew Giwa, Abdel Hamad, Zahra Omidian, Angela Yang, Neha Majety, Tiffany Jackson, Kusuma Ananth, Mohanraj Sadasivam, Marjan Behzadirad, Thomas Donner and Rizwan Ahmed<br> <br>5. Insulin Therapy – A Century of Progress<br>by Geremia Bolli<br> <br>6. Treatment and Prevention of Type 1 Diabetes in the 21<sup>st</sup> Century<br>by Jay S Skylar, David Baidal, and J Sosenko<br> <br>7. Differentiation of Diabetes by Pathophysiology: A Focus on Insulin Deficiency vs Insulin Resistance<br>by Adrian Heald<br> <br>Section 2b: Syndromes of Insulin Excess<br><br>8. Congenital Hyperinsulinism<br>by Katherine Lord and Diva D De Leon<br> <br>9. Hypoglycemic Disorders in Adults<br>by Adrian Vella and Maheswaran Dhanasekaran<br> <br>Section 2c: Insulin Resistance in Human Disease<br><br>10. Obesity and Insulin Resistance: Pathophysiology and Principles of Therapy<br>by Rita Basu<br> <br>11. The Cardiometabolic Syndrome and Vascular Disease: Pivotal Role of Insulin<br>by Michael D Shapiro, Trevor Caldarera, and Jordan Tannenbaum<br> <br>12. Insulin, IGF-1, and Cancer: Pathogenic Considerations and Therapeutic Opportunities<br>by John Vincent Reynolds and Jessie Andrea Elliott<br> <br>13. Insulin and Neurodegenerative Diseases<br>by Heather A Ferris<br> <br>14. Non-pharmacological, Pharmacological, and Surgical Options for Obesity-related Cardiometabolic Disorders: Metabolic and Clinical Impact<br>by Alexander Dimitri Miras, Mariana Abdel-Malek, and Darmiga Thayabaran<br> <br>15. Syndromes of Severe Insulin Resistance: Lessons from Nature<br>by Andrew J Krentz
