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Cannabis and Khat in Drug Discovery

The Discovery Pipeline and the Endocannabinoid System

Specificaties
Paperback, blz. | Engels
Elsevier Science | 2024
ISBN13: 9780323959278
Rubricering
Elsevier Science e druk, 2024 9780323959278
€ 229,00
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Samenvatting

Cannabis and Khat in Drug Discovery: The Discovery Pipeline and the Endocannabinoid System provides comprehensive coverage of two important psychoactive plants: Khat and Cannabis. Initial research has found that compounds and derivatives from Cannabis and Khat are found to have promising properties that can be used for the discovery, design and development of potential drug leads against various diseases. This book extensively discusses the drug discovery and allied sciences of these compounds in the drug discovery pipeline, including basic research and computer aided modeling in ligand-drug interactions and their interactions with the endocannabinoid system. Categorized into sections including, chemical analyses and bioassays, medicinal chemistry, chemical biology and pharmacology, clinical applications, and policy and regulations, this book covers the methods and protocols involved and will be of interest to students, researchers, policymakers and all those involved in drug discovery research.

Specificaties

ISBN13:9780323959278
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

<p>Part A: Introduction<br>1. Introduction to Catha edulis and Cannabis<br>2. Ethnomedicinal uses of cannabis<br>3. Ethnomedicinal uses of Catha edulis<br>4. Cannabis chemotypes: sativa, indica, and others<br>5. Cannabinoids and their subclasses – Lucia Kabanga<br>6. The Chemistry and Pharmacology of Tetrahydrocannabinol and Cannabidiol<br>7. Cannabis infused foods: Efficacy, safety and regulation<br>8. Water resource demands and management in the growth of cannabis industrialization<br><br>Part B: Chemical analyses and bioassays<br>1. Extraction and isolation of cannabinoids<br>2. Chromatographic fingerprinting and spectroscopic profiling of cannabinoids<br>3. Antiviral properties of cannabidiol (CBD)<br>4. In vitro and in vivo assays and safety profiles of cannabinoids<br>5. In vitro and in vivo toxicology of cannabinoids<br>6. Immunomodulatory properties of cannabis<br>7. Pharmacologically active ingredients from Catha edulis<br>8. Phytochemistry of Catha edulis<br>9. In vitro and in vivo assays and toxicity profile of Catha edulis<br>10. Physicochemical properties of Catha edulis<br>11. Cannabis and reproductive physiology<br><br>Part C: Medicinal Chemistry, Chemical Biology and Pharmacology<br>1. Cannabinergics<br>2. Medicinal Chemistry of cannabinoids and endocannabinoids<br>3. Biosynthesis of cannabinoids and endocannabinoids<br>4. Cannabinoid ligands and receptors<br>5. Medicinal Chemistry of selected active compounds in Catha edulis<br>6. Catha edulis, Cannabis and the nervous system<br>7. Structural analysis of Catha edulis’s sympathomimetric amines to amphetamine and adrenaline<br>8. Stimulants from Catha edulis<br>9. Catha edulis and concomitant drug bioavailability<br>10. Interactions of Catha edulis agents with CB2 receptors<br>11. In Silico Drug Design Studies of Bioactives in Catha edulis, Cannabis, and their derivative<br><br>Part D: Catha edulis and cannabinoids in disease management; Clinical aspects Prologue to part D 1. Cannabis in pain management<br>2. Cannabinoids in cancer management<br>3. Cannabis in antimicrobial drug development<br>4. Cannabis in fungal infection management<br>5. Cannabis in Post-traumatic stress disorder management<br>6. Cannabis use in Unani Medicinal practices<br>7. Catha edulis in antimicrobial drug development<br>8. Dependence syndrome in Catha edulis product uses<br>9. Catha edulis in pain management<br>10. Catha edulis and type 2 diabetes mellitus<br>11. Catha edulis in the management of cancers<br>12. Clinical uses of cannabis and Catha edulis products<br>13. Cannabinoid therapy and concomitant administered agents<br>14. Dependence syndrome in cannabis product uses<br>15. Hepatocellular injury from Catha edulis<br>16. Innovative cannabis products on the market<br>17. Pestcides and disease causing contaminants in Khat and khat products<br><br>Part E: Policy and regulations<br>1. Industrial and medical use approvals and regulations of Cannabis products<br>2. Conservation of Cannabis species and their products<br>3. Policy and Regulation of Catha edulis product uses<br>4. Future perspectives on the use of cannabis and Catha edulis products</p>
€ 229,00
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        Cannabis and Khat in Drug Discovery