Early Vascular Aging (EVA)

Section 1 – Introduction<br> <ol><li>Historical Aspects and Biology of Aging</li></ol>PETER M. NILSSON<br> <ol><li>The 9 paradigm shifts in cardiovascular aging research </li></ol>PIERRE BOUTOUYRIE AND PEDRO GUIMARAES CUNHA<br> <ol><li>Vascular Aging and CV Disease</li></ol>PEDRO GUIMARAES CUNHA AND MICHAEL H. OLSEN<br> <br>Section 02 – Lifecourse approach and population based studies<br> <ol><li>Aging Population: Challenges and Opportunities in a Life Course Perspective</li></ol>ANGELO SCUTERI AND PETER M. NILSSON<br> <ol><li>Population-Based Studies: Milestones on the Epidemiological Timeline</li></ol>ERNST RIETZSCHEL AND MARC L. DE BUYZERE<br> <br>Lifetime Perspective of Vascular Aging<br> <ol><li>a. Lessons from the Amsterdam Growth and Health Longitudinal Study</li></ol>ISABEL FERREIRA, ROEL J. VAN DE LAAR, FRANK C.T. VAN DER HEIDE, AND COEN D.A. STEHOUWER<br> <ol><li>b. Cardiovascular Aging: Perspectives from Longitudinal Studies of Aging</li></ol>MAJD ALGHATRIF AND EDWARD G. LAKATTA<br> <ol><li>c. Lessons from the Cardiovascular Risk in Young Finns Study</li></ol>COSTAN G. MAGNUSSEN, SUVI P. ROVIO, KATJA PAHKALA, AND OLLI T. RAITAKARI<br> <ol><li>Early Vascular Aging in the Young</li></ol>ELAINE M. URBINA, PETER M. NILSSON, AND CARMEL M. MCENIERY<br> <ol><li>Ethnicity and Arterial Function</li></ol>J. KENNEDY CRUICKSHANK AND NADIA BENNETT<br> <br>Section 03 – Molecular, Cellular and Mechanist Contributions to Vascular Aging<br> <ol><li>Cellular and Molecular Determinants of Arterial Aging</li></ol>PATRICK LACOLLEY, PASCAL CHALLANDE, VERONIQUE REGNAULT, EDWARD G. LAKATTA, AND MINGYI WANG<br> <ol><li>Platelet/Leukocyte–Vessel Wall Interactions</li></ol>and Early Aging<br>VERONIQUE REGNAULT, JEREMY LAGRANGE, R€UMEYZA BASCETIN AND PATRICK LACOLLEY<br> <ol><li>Age-Induced Endothelial Dysfunction and Intima-Media Thickening</li></ol>MICHAELA KOZAKOVA AND ARNO SCHMIDT-TRUKSASS<br> <ol><li>Diabetes, Prediabetes, Metabolic Syndrome, and Large Artery Vascular Ageing</li></ol>COEN D.A. STEHOUWER, FRANK C.T. VAN DER HEIDE, MICHAELA KOZAKOVA, AND CARLO PALOMBO<br> <ol><li>The Cross-Talk Between the Macro- and the Microcirculation</li></ol>STEPHANE LAURENT, DAMIANO RIZZONI,AND ENRICO AGABITI-ROSEI<br> <ol><li>Changes in Peripheral Blood Pressure with Normal and Accelerated Aging</li></ol>S. FRANKLIN AND MICHAEL HECHT OLSEN<br> <ol><li>Changes in Arterial Stiffness with Normal and Accelerated Aging</li></ol>ROSA MARIA BRUNO AND PIERRE BOUTOUYRIE<br> <ol><li>Changes in Central Hemodynamics, Wave Reflection, and Heart_Vessel Coupling with Normal and Accelerated Aging</li></ol>THOMAS WEBER AND PATRICK SEGERS<br> <ol><li>Arterial Stiffness and Blood Pressure Variability</li></ol>GIANFRANCO PARATI, JUAN EUGENIO OCHOA,GIUSEPPE SCHILLACI, AND PAOLO SALVI<br> <ol><li>Chronic Inflammation in Atherosclerosis and Arteriosclerosis</li></ol>JAN ISABEL GONCALVESA, LUCA ZANOLI, JAN NILSSON, AND ANDREAS EDSFELDT<br> <ol><li>Nonhemodynamic Components of EVA: Polycystic Ovary Syndrome (PCOS)</li></ol>IRENE LAMBRINOUDAKI and ELENA ARMENI<br> <ol><li>Microbiota, Diet, Oral Health and Vascular Aging </li></ol>DAVIDE AGNOLETTI, FEDERICA PIANI, SILVIA TURRONI, AND MADELEINE JOHANSSON<br> <br>Section 04 – Biomarkers, risk prediction and phenotypes of vascular aging<br> <ol><li>Traditional Versus New Models of Risk Prediction</li></ol>THOMAS BASTHOLM OLESEN AND MICHAEL HECHT OLSEN<br> <ol><li>Estimated Arterial Stiffness</li></ol>JULIE VISHRAM-NIELSEN, DIMITRIOS TERENTES-PRINTZIOS, MICHAEL HECHT OLSEN, AND CHARALAMBOS VLACHOPOULOS<br> <ol><li>Vascular Aging Biomarkers: Methodological Measurement Consensus and Reference Values </li></ol>PIERRE BOUTOUYRIE<br> <ol><li>Imaging Biomarkers: Carotid Intima-Media Thickness and Aortic Stiffness as Predictors of Cardiovascular Disease</li></ol>CHARALAMBOS VLACHOPOULOS, GEORGIOS GEORGIOPOULOS, GEORGIOS MAVRAGANIS, KIMON STAMATELOPOULOS, AND COSTAS TSIOUFIS<br> <ol><li>Imaging Biomarkers: Flow-Mediated Dilation as Predictor of Cardiovascular Disease </li></ol>ROSA MARIA BRUNO, SMRITI BADHWAR, ELISABETTA BIANCHINI, AND LORENZO GHIADONI<br> <ol><li>Genetic Markers in Prediction of Cardiovascular Disease</li></ol>MARTIN W. MCBRIDE, DELYTH GRAHAM, SIMON FISHER, CARA TRIVETT, AND MANSHI ZHOU<br> <ol><li>Phenotypes of Vascular Aging – Vascular Chronobiologic asynchrony</li></ol>PEDRO GUIMARA ES CUNHA, PETER M. NILSSON, PIERRE BOUTOUYRIE, MICHAEL HECHT OLSEN, AND STEPHANE LAURENT<br> <br>Section 05 – Vascular aging, organ damage and late stage disease<br> <ol><li>Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes</li></ol>AGNE-LAUCYTE-CIBULSKIENE AND MIKAEL GOTTS€ATER<br> <ol><li>Arterial Aging, Blood Pressure, and Brain Damage</li></ol>ANGELO SCUTERI, STEPHANIE DEBETTE, AND ALBERTO AVOLIO<br> <ol><li>Clinical Implications of Ventricular-Arterial Coupling and the Role of Therapeutic Interventions</li></ol>IGNATIOS IKONOMIDIS, GEORGE PAVLIDIS, AND DIMITRIOS VLASTOS<ol><li>Systemic Ventricular–Arterial Coupling and Heart Disease</li></ol>JULIO A. CHIRINOS<br> <br>Section 06 – Translating research into clinical practice, with precision cardiovascular medicine: Implications of vascular aging <br> <ol><li>Vascular Aging and Clinical Trials </li></ol>PIERRE BOUTOUYRIE AND ROSA MARIA BRUNO<br> <ol><li>a. PART I Treatment of Abnormalities in Lipid Metabolism and EVA</li></ol>VASILIOS KOTSIS<br> <ol><li>b. Part II: Early Vascular Aging and Obesity Treatment</li></ol>JENS JORDAN<br> <ol><li>c. Part III: Treatment with antidiabetes drugs—Effects on blood pressure and central hemodynamics</li></ol>PETER M. NILSSON<br> <ol><li>d. Part IV: Arterial Stiffness as Treatment Target: The SPARTE Study</li></ol>STEPHANE LAURENT<br> <ol><li>Lifestyle Intervention: What Works?</li></ol>PANAGIOTIS XAPLANTERIS AND CHARALAMBOS VLACHOPOULOS<br> <ol><li>Targeting Blood Pressure Lowering and the Sympathetic Nervous System</li></ol>DAGMARA HERING AND KRZYSZTOF NARKIEWICZ<br> <ol><li>Targeting Central Blood Pressure Through the Macro- and Microcirculation Cross-Talk STEPHANE LAURENT, ROSA MARIA BRUNO, CLAUDIA AGABITI-ROSEI, CAROLINA DE CIUCEIS, AND DAMIANO RIZZONI</li></ol> <br>Cardiovascular Aging in Clinical Guidelines<br> <ol><li>a. Cardiovascular Prevention Strategies in a Life Course Perspective</li></ol>PETER M. NILSSON<ol><li>b. Cardiovascular Prevention Strategies in Patients With Comorbidities (Metabolic, Chronic Inflammation, Immunomodulation, Cancer, and Treatment-Induced Arterial Changes)</li></ol>ANTONIOS ARGYRIS AND ATHANASE D. PROTOGEROU<ol><li>c. Cardiovascular Risk Prediction</li></ol>THOMAS BASTHOLM OLESEN AND MICHAEL HECHT OLSEN<ol><li>d. Target Organ Damage</li></ol>MARIA LORENZA MUIESAN AND CLAUDIA AGABITI ROSEI<ol><li>e. Therapeutic Implications of Early Vascular Aging</li></ol>PIERRE BOUTOUYRIE, ROSA MARIA BRUNO, AND STEPHANE LAURENT<ol><li>New Drugs Under Development for Cardiovascular Prevention</li></ol>STEPHANE LAURENT AND ULRIKE M. STECKELINGS<br> <ol><li>Specific Pathways to Prevent Early Vascular Aging</li></ol>TINE DE BACKER, PIERRE BOUTOUYRIE, AND L VAN BORTEL<br> <ol><li>Immunization, Vaccines, and Immunomodulation</li></ol> <br>Section 07 – Global Mapping of Vascular Aging Research<br> <ol><li>a. European Research Centres</li></ol>The ARTERY Society. The Association for Research Into Arterial Structure and Physiology<br>THOMAS WEBER, CARMEL M. MCENIERY, ST_EPHANE LAURENT, AND JOHN COCKCROFT<br>Clinical Pharmacology Unit—Hopital Europeen Georges Pompidou-APHP (Paris, France)<br>PIERRE BOUTOUYRIE<br>Lund University, Department of Clinical Sciences, Malmo, Sweden<br>PETER M. NILSSON AND ISABEL GONCALVES<br>Arterial Aging From Bedside to Bench ...and Back<br>ANGELO SCUTERI<br>The Maastricht study, The Netherlands: A population-based cohort study with oversampling of participants with type 2 diabetes<br>COEN D.A. STEHOUWER<br>Erasmus MC University Medical Center, Rotterdam, The Netherlands<br>FRANCESCO MATTACE RASO<br>Acute and Chronic Cardiovascular Deficiency, Nancy, France 000<br>PATRICK LACOLLEY<br>Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria<br>THOMAS WEBER<br>Department of Sport, Exercise and Health at University of Basel, Division of Sport and Exercise Medicine, Basel<br>ARNO SCHMIDT-TRUCKSASS<br>Biophysical Models for Medical Applications (BioMMedA), Ghent, Belgium<br>PATRICK SEGERS<br>Medical University of Gdansk, Poland<br>KRZYSZTOF NARKIEWICZ<br>Department of Geriatrics and Stroke Medicine, Brighton, UK<br>C. RAJKUMAR<br>Centre for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Hospital Senhora da Oliveira/Minho University, Guimaraes, Portugal<br>JORGE COTTER AND PEDRO GUIMARAES CUNHA<br>Preventive Cardiology and Echocardiography Laboratory<br>IGNATIOS IKONOMIDIS<br>Institute of Preventive Pediatrics, Technical University of Munich, Munich, Germany<br>RENATE OBERHOFFER-FRITZ<br>Hypertension and Vascular Risk Unit, Internal Medicine Department, Hospital Clinic of Barcelona, Spain<br>CRISTINA SIERRA AND MIGUEL CAMAFORT<br>Unitat d&rsquo;Hipertensio Arterial i Risc Vascular, Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain<br>ANNA OLIVERAS AND SUSANA VA ZQUEZ<br>Nephrology, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy<br>LUCA ZANOLI<br>CARDIO HEALTH-LAB: Cardiovascular Pathophysiology and Circulatory Health Laboratory<br>RAFFAELE DE CATERINA AND CARLO PALOMBO<br>Italian National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa Italy<br>FABIO ANASTASIO RECCHIA AND ELISABETTA BIANCHINI<br>Cardiovascular Internal Medicine, University of Bologna, Bologna, Italy<br>CLAUDIO BORGHI<br>Carvascare Research Group, Cuenca, Spain<br>IVAN CAVERO-REDONDO<br>Early Vascular Aging General Practitioner Research Centre, Budapest, Hungary<br>JANOS NEMCSIK<br>Cardiovascular Center, University Hospital Ghent, Belgium<br>TINE DE BACKER<br>Primary Care Research Unit of Salamanca (APISAL), Salamanca, Spain<br>LUIS GARCIA ORTIZ<br>ASKLEPIOS Study, Ghent, Belgium<br>ERNST RIETZSCHEL AND PATRICK SEGERS<br>Hypertension Excellence Center, Brescia, Italy<br>MARIA LORENZA MUIESAN AND ANNA PAINI<br>Laboratory of Vascular Biology, Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy<br>MARIA LORENZA MUIESAN AND CAROLINA DE CIUCEIS<br>Department of Clinical and Experimental Medicine, University of Pisa, Italy<br>STEFANO TADDEI AND LORENZO GHIADONI<br>The Unit for Vascular Investigations, Vilnius University Santaros Klinikos, Lithuania<br>LIGITA RYLISKYTE AND JOLITA BADARIENE<br>Cardiovascular Prevention and Research Unit, Clinic and Laboratory of Pathophysiology, Department of Medicine, School of Health Sciences, National andKapodistrianUniversity of Athens<br>ATHANASE D. PROTOGEROU<br>SDCO—Steno Diabetes Center Odense, Odense, Denmark<br>KURT HØJLUND<br>Research Centre in Physical Activity, Health and Leisure (CIAFEL)<br>LUCIMERE BOHN, JORGE MOTA, AND JOSE OLIVEIRA<br>Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany<br>JENS JORDAN<br>Research Centre of Applied and Preventive Medicine/Centre for Population Health Research, Turku, Finland<br>OLLI T. RAITAKARI<br>Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy<br>SILVIA TURRONI<br>Menopause Unit, 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece<br>IRENE LAMBRINOUDAKI<br>Hypertension and Vascular Risk Unit, Internal Medicine Service, University Hospital of Sagunto, Sagunto (Valencia), Spain<br>ENRIQUE RODILLA<br>Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, United Kingdom<br>ALUN HUGHES<br>Centre for Cardiovascular Health and Aging, Cardiff, United Kingdom<br>BARRY J. MCDONNELL<br>Peripheral Vessels Unit, First Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece<br>CHARALAMBOS VLACHOPOULOS<br> <ol><li>b. Asia/Australia Research Centers</li></ol> <br>Vascular Research Section, Department of Cardiology, Tokyo Medical University, Tokyo, Japan<br>HIROFUMI TOMIYAMA<br>Jichi Medical University Center of Excellence in Community Medicine Cardiovascular Research and Development (JCARD), Tochigi, Japan<br>KAZUOMI KARIO<br>Blood Pressure and Arterial Function (BPAF) Laboratory, Macquarie Medical School, Macquarie University, Sydney, Australia<br>MARK BUTLIN<br>Menzies Institute for Medical Research, Hobart, Australia<br>RACHEL EMMA CLIMIE<br>Menzies Institute for Medical Research, Hobart, Australia<br>JAMES SHARMAN<br>Miyagi University of Education Medical Center, and Tohoku University Graduate School of Medicine, Sendai, Japan<br>JUNICHIRO HASHIMOTO<br> <br>52. c. North American Research Centers<br> <br>History of North American Artery Society<br> <br>Preventive Cardiology, Cincinnati Children&rsquo;s Hospital Medical Center, Cincinnati, OH, United States<br>ELAINE M. URBINA<br>Iowa Translational Vascular Physiology Lab, Department of Health and Human Physiology, University of Iowa, Iowa City, United States<br>GARY L. PIERCE<br>Chirinos Lab at the University of Pennsylvania<br>JULIO A. CHIRINOS, KATHERINE GREENE, AND HANNAH MAYNARD<br>Integrative Human Physiology Laboratory, University of Massachusetts Boston, Boston, MA, United States<br>TRACY BAYNARD AND BO FERNHALL<br>Aging and Vascular Physiology Lab, Eugene, OR, United States<br>ASHLEY WALKER<br>UNC Cardiometabolic Lab, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States<br>LEE STONER<br>Integrative Physiology Laboratory, University of Illinois at Chicago, United States<br>ROBERT W. MOTL<br> <br>53. d. Latin American Research Centers<br> <br>ARTERY LATAM Society: Brief Historical Summary<br>EDUARDO C.D. BARBOSA, PEDRO FORCADA, AND LUIS MARIA PUPI<br>Clinic of Hypertension and Associated Metabolic Diseases—CHAMA, Rio de Janeiro, Brazil<br>MARIO FRITSCH NEVES<br>Hypertension Unity—Instituto do Coracao do HCFMUSP, Sao Paulo, Brazil<br>LUIZ APARECIDO BORTOLOTTO<br>Hypertension Unit. Cardiology Department, Medicine School, Federal University of Goias, Brazil<br>WEIMAR KUNZ SEBBA BARROSO<br>Research Group on Hypertension, Arterial Stiffness and Vascular Aging (GPHARV), Maringa, Brazil<br>ROGERIO TOSHIRO PASSOS OKAWA, JAQUELINE LYRIO BERMUDES OKAWA, AND WENDELL ARTHUR LOPES<br>Vascular Research Center and Its Risk Factors Vascor, Salvador, Bahia, Brazil<br>LUCELIA BATISTA NEVES CUNHA MAGALHAES<br>Laboratory of Vascular Dynamics and Non-Invasive Hemodynamics. Hosp. Sao Francisco—Santa Casa de Porto Alegre—Brazil<br>EDUARDO COSTA DUARTE BARBOSA<br>Cardiometabolic Center Dr. Luis Marıa Pupi, Ciudad Autonoma de Buenos Aires, Argentina<br>LUIS MARIA PUPI, FABIANA CALABRIA, AND PABLO MARIA PUPI<br>CardioArenales: Noninvasive Vascular Laboratory<br>PEDRO FORCADA, HORACIO ALMADA, AND RICARDO GARCIA<br>Centro de Hipertension Arterial y Biomecanica Vascular<br>FABIANA CALABRIA AND PABLO G. PIZZALA<br>SICOR Clinical and Research Center, Medellin, Colombia<br>DAGNOVAR ARISTIZABAL<br>Metabolism and Biomechanics in Systemic Vasculopathy<br>JAVIER OSVALDO SARY<br>Arterial Stiffness Laboratory<br>ERNESTO CARDONA MUNOZ AND CARLOS RAMOS BECERRA<br>University Hospital, Fundacion Favaloro, Arterial Hypertension, Metabolic Unit<br>RAMIRO SANCHEZ AND AGUSTI&acute;N RAMIREZ<br>Ricardo Gutierrez Children&acute;s Hospital, Buenos Aires, Argentina<br>SARDELLA ANGELA<br>Masira Research Institute, Medical School, Universidad de Santander (UDES), Bucaramanga, Colombia<br>PATRICIO LOPEZ-JARAMILLO<br> <br>54. e. Network for Research in Vascular Aging<br>CHRISTOPHER CLEMENS MAYER, JORDI ALASTRUEY, ROSA MARIA BRUNO, RACHEL EMMA CLIMIE, ANDREA GUALA, BERNHARD HAMETNER, IOANA MOZOS, CHLOE PARK, GIACOMO PUCCI, DIMITRIOS TERENTES-PRINTZIOS, AND ELISABETTA BIANCHINI