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Pharmacoepigenetics
Specificaties
Paperback, blz. | Engels
Elsevier Science | 2025
ISBN13: 9780443187223
Rubricering
Elsevier Science e druk, 2025 9780443187223
Onderdeel van serie Translational Epigenetics
336,99
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Samenvatting

Pharmacoepigenetics, Second Edition, Volume Ten in the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development. Here, leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.

This new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges are also discussed.

Specificaties

ISBN13:9780443187223
Taal:Engels
Bindwijze:paperback
Uitgever:Elsevier Science
Serie:Translational Epigenetics

Inhoudsopgave

<p>I. General Principles<br>1.The Epigenetic Machinery in the Life Cycle<br>2. Pharmacoepigenetics: Basic Principles for Personalized Medicine<br>3. Pharmacoepigenetic Processors<br>4. Epigenetic regulation of genes involved in drug metabolism<br>5. MicroRNA-Dependent Gene Regulation of the Human Cytochromes P450<br>6. Epigenetic regulation of transporter genes<br>7. Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis<br><br>II. Drug Development and Drug-related events<br>8. Epigenetic Drugs<br>9. Pharmacoepigenetics of Novel Nucleoside DNA Methyltransferase Inhibitors<br>10. Pharmacoepigenetics: Novel Mechanistic Insights in Drug Discovery and Development Targeting Chromatin-Modifying Enzymes<br>11. Pharmacoepigenetics of EZH2 Inhibitors<br>12. Regulators of Histone Acetylation: Bromodomain Inhibitors<br>13. Bromodomain Inhibition and Its Application to Human Disease<br>14. Pharmacoepigenetics of Brassica-Derived Compounds<br>15. Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity<br>16. Epigenetic-related Drug Resistance<br>17. Toxicoepigenetics<br><br>III. Pharmacoepigenetics of Cancer<br>18. Epigenetics of Aging and Cancer: A Comprehensive Look<br>19. Epigenetic Drug Discovery for Cancer<br>20. Pharmacoepigenetics of Histone Deacetylase Inhibitors in Cancer<br>21. Pharmacoepigenetics of LSD1 Inhibitors in Cancer<br>22. Epigenetic effects of AntiGan in Cancer<br>23. Pharmacoepigenetic Considerations for the Treatment of Breast Cancer<br>24. Pharmacoepigenetics of Acute Myeloid Leukemia<br>25. Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma<br>26. Pharmacoepigenetics of Gastrointestinal disorders and Cancer<br>27. Pharmacoepigenetics of Chinese Herbal Components in Cancer<br><br>IV. Pharmacoepigenetics of Cardiovascular disease and Related disorders<br>28. Epigenetics and Pharmacoepigenetics of myocardial infarction<br>29. Epigenetics and Pharmacoepigenetics of Arteriosclerosis<br>30. Epigenetics and Pharmacoepigenetics of Hypertension<br>31. Pharmacoepigenetics of Ancoagulants<br>32. Epigenetics in Doxorubicin Cardiotoxicity<br>33. Epigenetic effects of CardioSar in cardiovascular disorders<br><br>V. Pharmacoepigenetics of Central Nervous System disorders<br>34. Epigenetics and Pharmacoepigenetics of Neurodevelopmental and Neuropsychiatric Disorders<br>35. Pharmacoepigenetics and Toxicoepigenetics in Neurodevelopmental Disorders<br>36. Pharmacoepigenetics of Autism Spectrum Disorder<br>37. Pharmacoepigenetics of Antipsychotic Drugs<br>38. Pharmacoepigenetics of Bipolar Disorder<br>39. Pharmacoepigenetics of Major Depression<br>40. Epigenetics and Pharmacoepigenetics of Vestibulocochlear disorders<br>41. Epigenetics and Pharmacoepigenetics of Visual disorders<br>42. Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders<br>43. Epigenetic effects of Nosustrophine in Alzheimer’s disease<br>44. Epigenetic effects of Atremorine in Parkinson’s disease<br>45. Pharmacoepigenetics and Pharmacoepigenomics of Valproate in Neurodegenerative Disease<br>46. Pharmacoepigenetics of Memantine in Dementia<br><br>VI. Pharmacoepigenetics of Metabolic and Endocrine disorders<br>47. Pharmacoepigenetics in Type 2 Diabetes Mellitus<br>48. Epigenetics and Pharmacoepigenetics of hypercholesterolemia and lipid metabolism disorders<br>49. Pharmacoepigenetics of Statins<br>50. Epigenetics and Pharmacoepigenetics of Thyroid disorders<br><br>VII. Pharmacoepigenetics of Immunological and Inflammatory disorders<br>51. Pharmacoepigenetics of Immunological Disorders<br>52. Pharmacoepigenetics of Rheumatic Disorders<br>53. Epigenetics and Pharmacoepigenetics of Skin disorders<br>54. Pharmacoepigenetics of Systemic Lupus Erythematosus<br><br>VIII. Nutritional Epigenetics<br>55. Nutriepigenetics<br>56. Epinutraceuticals: Novel biomolecules with epigenetic effects<br><br>IX. Epigenetics and Pharmacoepigenetics of infectious disorders<br>57. Pharmacoepigenetic of bacterial infections<br>58. Pharmacoepigenetics of viral infections<br>59. Pharmacoepigenetics of COVID-19<br><br>X. Mendelian epigenetic disorders<br>60. Pharmacoepigenetics of Mendelian disorders associated with the epigenetic machinery</p>

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