Cannabis, Cannabinoids, and Endocannabinoids

<p>Cannabis Use, Neurobiology, Psychology, and TreatmentI. Setting the scene and introductory chapters1. Metabolomics of the cannabis plant; 2. The roots of Cannabis sativa: chemical and pharmacological profile; 3. Cannabis related compounds in beverages and food; 4. The impact of prenatal cannabis exposure: an overview; 5. Cannabinoid Genotoxicity and Congenital Anomalies: A Convergent Synthesis of European and USA Datasets; 6. Cannabis Genotoxicity and Cancer Incidence: A Highly Concordant Synthesis of European and USA Datasets; 7. Cannabis, Cognitive impairment and Car Crash risk </p> <p>II. Cannabis usage8. Recreational cannabis use: a French perspective of adverse effects; 9. Acute and chronic impact of cannabis on human cognition; 10. Polydrug users, use of cannabidiol (CBD) and abuse potential/Polydrug users, use of cannabinoids and abuse potential; 11. Cannabis stigmas: a narrative of features; 12. Alterations of THC and CBD ratios and impact on cognition; 13. When cannabis is used for medicinal purposes: a focus on back pain</p> <p>III. Pharmacological and Physiological Aspects14. Cannabis, cannabinoids and receptor responses; 15. Cannabidiol (CBD): abuse potential and withdrawal; 16. 4,5- Dihydro-1H-pyrazole/3,4-Diarylpyrazoline class of cannabinoid-1 (CB1R) receptor antagonists and their potential in medicinal applications </p> <p>IV. Neurobiology of cannabis17. Neurobiology of cannabis; 18. The kynurenine pathway, neurobiology and cannabis misuse: a new narrative; 19. Central nervous system cancers and use of cannabis and related products: an updated narrative; 20. Chronic cannabis users: links with glutamate and resting state connectivity; 21. Brain metabolic responses to cannabis use in people with multiple sclerosis: Insights from [18F]-FDG positron emission tomography and functional MRI; 22. Genetic Variation and Acute Responses to Cannabis; 23. Cell Signaling of the CB1 Cannabinoid Receptor via beta-arrestins, Cannabinoid Receptor Interacting Protein (CRIP1a) and other regulatory proteins; 24. Cannabis and impact on memory: from in utero to adults; 25. Central CB1 receptors and age-related changes: investigating the effects of DELTA-9-tetrahydrocannabinol; 26. Alcohol, cannabis and visual memory</p> <p>V. Neurobiology of cannabinoids27. The role of Delta-FosB in the plasticity of the cannabinoid system; 28. Functional profile of synthetic cannabinoid receptor agonists: exploring cannabinoid and non-cannabinoid targets; 29. Linking the G protein-coupled orphan receptor GPR55 to the cannabinoid receptors (CB1 and CB2): a new narrative; 30. Proteomic analysis of cannabinoids in human oligodendrocytes; 31. Cannabinoids and endocannabinoid signaling at the basal forebrain cholinergic system; 32. Cannabidiol (The major non-psychotropic cannabinoid in the cannabis plant) and the PI3K/Akt pathway in the CNS; 33. Effects of cannabidiol and other phytocannabinoids on ion channels;34. Cannabis, neurodevelopment and the "two-hit hypothesis"</p> <p>VI. New and synthetic cannabinoids35. Impact of tetrahydrocannabinol (THC ) and synthetic "spice"cannabinoids on nicotine use and abuse; 36. Synthetic cannabinoids: how do they compare to DELTA9-tetrahydrocannabinol: neurological effects and beyond</p> <p>VII. Biomarkers, analysis and screening37. The DSM-5 criteria of cannabis use disorder: methods and applications; 38. Cannabis and clinical high risk for psychosis: monitoring and smartphones</p> <p>VIII. Impact on non-neurological systems39. The impact of cannabis and cannabinoids on the skin; 40. Cannabis consumption in reproduction and teratogenicity; 41. Cannabis compounds and putative cytotoxicity: profile of cancer cells</p> <p>IX. Treatments, strategies and resources42. Motivational Interviewing for Cannabis Use Disorders: a narrative review from research to practice; 43. An Overview of Current Pharmacologic Interventions for Management of Cannabis Withdrawal and the Evidence for Their Use; 44. Managing cannabinoid hyperemesis syndrome in paediatrics: A new narrative review; 45. Gabapentinoids for the Treatment of Cannabis Use Disorder: A Focus on Human Laboratory Research; 46. Treating psychosis in users of synthetic cannabinoids</p> <p>X. Resources47. Cannabis and Web based Resources　</p> <p>Medicinal Usage of Cannabis and CannabinoidsI. Setting the scene and introductory chapters1. How medical cannabis may influence the future of medicine; 2. Medical cannabis and cannabinoids: how best to extract components from plant material; 3. Medicinal usage of cannabis and its impact on mental health among cancer patients and survivors; 4. Cannabis sativa as a traditional phytomedicine: a new narrative covering different countries; 5. Medical use of cannabis in the middle east; 6. What medicinal cannabis is used for: a focus on Canada; 7. New York perspectives of medical cannabis laboratory analysis; 8. Epigenetic regulations on the quality of clonal cannabis plants: secondary metabolites and profiles; 9. Aberrant use of medicinal cannabis: theoretical and empirical considerations; 10. Profile of older users of medical cannabis and cannabinoids; 11. Use of cannabidiol oil by caregivers: a focus on Alzheimer's disease; 12. Medicinal use of cannabis: adverse events as a balanced perspective</p> <p>II. Physiological aspects and metabolic aspects13. Physiopathology and use of cannabinoids for fibrotic diseases; 14. Cannabinoids in inflammation and atherosclerosis; 15. Targeting the CB(2) receptors and other endocannabinoid elements to delay disease progression in cardiovascular diseases; 16. BMI in cannabis users: regulation, mechanisms and public health impact </p> <p>III. Neurological, psychological and behavioural aspects17. Neuroprotection by cannabis related products, cannabidiol and cannabigerol, and associated mechanisms of action; 18. Cannabis terpenes as neuroprotective agents: a focus on alpha-bisabolol; 19. Cannabidiol in medicinal usage of stress: modelling investigations into cocaine; 20. Medicinal cannabis and neurocognition impairment; 21. Genetic models of audiogenic seizures: what they are and how cannabinoids and Cannabis-derived compounds can be used to alleviate their symptoms - an updated narrative; 22. Addressing the validity of cannabinoid therapy as an option for the treatment of substance use disorder</p> <p>IV. Pharmacological and cellular aspects23. Cannabidiolic acid (CBDA), features and profiles: anti-hyperalgesic effects; 24. Cannabis-drug interactions: implications for medicinal cannabis use; 25. Cannabinoid receptor subtype 2 (CB2R): features and targets for medical applications; 26. Medical use of cannabidiol and impact on cancer cell viability; 27. Anti-inflammatory and antioxidant and immunomodulatory effects of phytocannabinoid ‑caryophyllene: A mechanistic overview</p> <p>V. Symptom Control and Medicinal Uses28. Cancer patients and providers: Attitudes and beliefs of cannabis and cannabinoids use as a treatment; 29. CBD (cannabidiol) use in breast cancer chemotherapy; 30. Sleep: cannabis and cannabinoids use; 31. Cannabis and cannabis related products and their uses in aiding sexual health of men and women; 32. Symptom control in palliative care settings: The role of cannabis-based medicines; 33. Cannabidiol (CBD) Use in Fragile X Spectrum Disorders; 34. Hempseed (Cannabis sativa) and ameliorative effects in hypercholesterolemia; 35. Benzodiazepines and cannabis use; 36. Features of (+)-trans-cannabidiol-2-hydroxy pentyland applications to disease: a focus on usage in diabetic nephropathy; 37. Medical use of cannabis: applications to Tourette syndrome; 38. Cannabinoids and their use in chronic non-cancer pain: a new narrative review; 39. Endometriosis: features and potential role of medical cannabis; 40. Cannabis usage for Crohn's disease and ulcerative colitis: a narrative; 41. Medical cannabis and use in migraine; 42. Cannabidiol (CBD ) and potential in medicinal use in rheumatoid arthritis; 43. Role of Cannabinoids in Glaucoma: Lowering Intraocular Pressure or Neuroprotection; 44. Medicinal potential of anandamide as a representative endocannabinoid and its effect at the cellular level in skin</p> <p>VI. Resources45. Medical Cannabis and Resources　</p> <p>Neurobiology, Physiology, And The Endocannabinoid SystemI. Setting the scene and introductory chapters1. Distribution of the endocannabinoid system: linking signalling and development; 2. The endocannabinoid system, immunomodulation, and LPS-induced inflammation; 3. Physiology of the endocannabinoid systems: imaging and the use of positron emission tomography (PET); 4. The endocannabinoid system and aging; 5. The endocannabinoid system and post traumatic stress disorder (PTSD): a new narrative</p> <p>II. Neurobiology of the endocannabinoid system6. The protective effect of the endocannabinoid system in neurotoxin induced damage to hippocampal neurons: a focus on light and electron microscopy; 7. Endocannabinoid Signaling and excitatory and inhibitory synapses; 8. The endocannabinoids and potassium channels: an updated narrative; 9. Social interactions and neural activity: linking cellular studies and endocannabinoid signalling; 10. Exercise and Parkinson's disease: linking in the cannabinoid type 1 (CB1) and type 2 (CB2), and mu-opioid receptors; 11. The endocannabinoids system and endocannabinoid receptors in sleep; 12. Endocannabinoids and inhalant misuse: neuropsychological aspects; 13. Fatty acid amide hydrolase (FAAH) in substance use disorders: FAAH regulation and inhibition in cannabis, alcohol, nicotine, stimulant, and opioid use disorders; 14. Treatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: interlinking the endocannabinoid system; 15. WWL70: linking the hydrolyses 2-arachidonoylglycerol, endocannabinoid and eicosanoid pathways: therapeutic potential and neurological disease; 16. Endocannabinoid catabolic enzyme inhibitors and pain alleviation; 17. The endocannabinoid system in health and disease: features in epilepsy; 18. The endocannabinoid system and autoimmune demyelination: a focus on multiple sclerosis; 19. Endocannabinoid signaling and the lateral habenula; 20. On the interplay among endocannabinoid, noradrenergic and glucocorticoid systems: evidence from aversive memory studies</p> <p>III. Receptor biology and responses 21. Adenosine A2A-cannabinoid CB1 receptor heteromers in the brain: From trans-inhibition to trans-activation; 22. Hippocampal CB1, CB2 receptors, the endocannabinoid system and fear memory; 23. Beta-caryophyllene, the CB2 cannabinoid receptor-specific agonists and wound healing; 24. The nigrostriatal dopaminergic pathway: impact of WIN 55212-2 as a potent cannaboinoid receptor agonist; 25. Peripheral cannabinoid receptor 1 antagonists and impact on adipocytes; 26. Endocannabinoid system receptors in plasma membranes : extraction, lipid rafts and the cortex; 27. Applications to wound healing: cannabinoid receptor 1 antagonism and collagen deposition; 28. Role of the Transient Receptor Potential Vanilloid 1 (TRPV1), a component of the endocannabinoid system, in anxiety, depression, and cocaine addiction; 29. Allosteric modulators of the endocannabinoid system: Org27569 and cannabinoid receptor 1 (CB1); 30. Naturally occurring DELTA-9-tetrahydrocannabinol-derivatives and binding to CB1 and CB2 receptors: Linking in the endocannabinoid system</p> <p>IV. Profiles and behaviour of selective endocannabinoids31. New cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system; 32. Fatty acid amide hydrolase, the endocannabinoid anandamide and neurological disease; 33. The endocannabinoid-system in the immuno-biology of dendritic cells; 34. Palmitoylethanolamide and other anandamide congeners in neuroinflammation-based disorders: linking in the endocannabinoid system; 35. Endocannabinoid modulation of synaptic function and behavior in the dorsomedial hypothalamus; 36. Key role of anandamide and the endocannabinoid system in the modulation of cardio-renal homeostasis; 37. The endocannabinoid system: Signaling and social motivation</p> <p>V. Exogenous, synthetic other compounds linking in the endocannabinoid system38. Safety and toxicology of the dietary cannabinoid beta-caryophyllene; 39. Synthetic cannabimimetics: an overview </p> <p>VI. Compartive studies in non neurological systems 40. Non Neurological Aspects of the Endocannabinoid System: Non Alcoholic Fatty Liver Disease; 41. Components of the Endocannabinoid system: Hepatic expression levels of the cannabinoid receptors and microRNAs; 42. Tumour growth and the endocannabinoid system: investigating CB2 agonists; 43. Linking Endocannabinoid System, Palmitoylethanolamide and Sarcopenia in view of therapeutic outcomes</p> <p>VII. Resources44. Endocannabinoids and Resources </p>