Alzheimer's Disease Research Guide

1. Introduction: Collaboration and Competition Together to Maximize the Velocity of Research and Development<br>2. Pathological Chronology and Pathological Biochemistry: The Beginning of The Beginning<br>3. Human Genetics: Establishment of Cause-And-Effect Relationships<br>4. Two Major Culprits: Amyloidogenic Aß And Non-Amyloidogenic Tau<br>5. Exact relationship between Aβ40 and Aβ42<br>6. Metabolism of Aβ: Catabolic and glimphatic systems<br>7. Biology of time: Temporal distance between cause and effect<br>8. 1st generation animal moβdels of Aβ amyoloidosis: Pros and cons of overexpression paradigm<br>9. Creation of single APPKNOCK-IN mouse models and of single MAPTNOKCK-IN models: Demonstration of AB-Tau axis<br>10. Application of Mouse Models to the experimental studies of AD<br>11. Neuroinflammation: Microgliosis and Astrocytosis in the days of microscopic omics<br>12. Central and peripheral nervous system, immune systems and digestive system: AD as a systemic disorder<br>13. Failure of more than 400 candidate medications in clinical trials before 2020<br>14. Therapeutic antibodies as a Wright brothers' airplane: Clinical proof-of-concept<br>15. Biomarkers for presymptomatic diagnosis and prognosis<br>16. Targeting somatostatin receptor heterodimer for developing safe, effective and ineffective and inexpensive medications<br>17. Application of genome editing to the treatment of familial AD<br>18. Identifying significant and insignificant publications: Prelude for chapter XIX<br>19. Journal of negative data for the days of generative AI-assisted publication<br>20. Conclusions