Zoran Rankovic,
Richard Morphy
John Wiley & Sons
e druk, 2010
9780470257616
Lead Generation Approaches in Drug Discovery
Specificaties
Gebonden, 308 blz.
|
Engels
John Wiley & Sons |
2010
ISBN13: 9780470257616
Rubricering
Verwachte levertijd ongeveer 16 werkdagen
Gratis verzonden
Samenvatting
This resource provides an integrated and comprehensive overview of modern approaches to drug lead discovery. Each chapter in this book reviews the theoretical background and application of a key technology in drug discovery, complemented by relevant case studies. The coverage includes the key approaches for drug design and discovery high–throughput screening, fragment screening, multi–target drugs, de novo design, ADMET, natural products. This cutting–edge reference helps medicinal chemists in biotech, pharmaceutical, and other research contexts consider all possible avenues in starting their drug research programs.
Specificaties
Inhoudsopgave
PREFACE.
<p>CONTRIBUTORS.</p>
<p>1 Lead Discovery: The Process (William F. Michne).</p>
<p>2 High Throughput Screening Approach to Lead Discovery (Zoran Rankovic, Craig Jamieson, and Richard Morphy).</p>
<p>3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath).</p>
<p>4 Fragment–Based Lead Discovery (Jeffrey S. Albert).</p>
<p>5 Design of Multitarget Ligands (Richard Morphy and Zoran Rankovic).</p>
<p>6 De novo Drug Design (Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak).</p>
<p>7 Role of Natural Products in Drug Discovery (Hugo Lachance, Stefan Wetzel, and Herbert Waldmann).</p>
<p>8 Early Screening for ADMET Properties (Dennis A. Smith).</p>
<p>9 Role of Chemistry in Lead Discovery (Roland E. Dolle and Karin Worm).</p>
<p>INDEX.</p>
<p>CONTRIBUTORS.</p>
<p>1 Lead Discovery: The Process (William F. Michne).</p>
<p>2 High Throughput Screening Approach to Lead Discovery (Zoran Rankovic, Craig Jamieson, and Richard Morphy).</p>
<p>3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath).</p>
<p>4 Fragment–Based Lead Discovery (Jeffrey S. Albert).</p>
<p>5 Design of Multitarget Ligands (Richard Morphy and Zoran Rankovic).</p>
<p>6 De novo Drug Design (Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak).</p>
<p>7 Role of Natural Products in Drug Discovery (Hugo Lachance, Stefan Wetzel, and Herbert Waldmann).</p>
<p>8 Early Screening for ADMET Properties (Dennis A. Smith).</p>
<p>9 Role of Chemistry in Lead Discovery (Roland E. Dolle and Karin Worm).</p>
<p>INDEX.</p>