Flavonoid Pharmacokinetics
Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology
Samenvatting
Highlighting the extremely important preclinical aspects of flavonoids, including pharmacokinetics and analysis in biological samples,
Flavonoid Pharmacokinetics covers the methods of analysis and pharmacokinetics (preclinical and clinical) of flavonoids to help readers comprehend pharmacokinetic terminology, understand the large number of compounds that encompass the flavonoid family, appreciate the multiple analytical methods available, and assess preclinical and clinical pharmacokinetics of flavonoids and similar chemical–derived compounds. The book uses applicable examples in different preclinical species and humans to strengthen pharmacokinetic concepts and to demonstrate how they apply on the preclinical and clinical drug development process.
Specificaties
Inhoudsopgave
<p>Preface xiii</p>
<p>Contributors xv</p>
<p>1 Polyphenols and Flavonoids: An Overview 1<br /> Jaime A. Yáñez, Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega–Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies</p>
<p>2 Analysis of Flavonoids through Chromatography 71<br /> Jody K. Takemoto, Stephanie E. Martinez, and Neal M. Davies</p>
<p>3 Chiral Methods of Flavonoid Analysis 117<br /> Jaime A. Yáñez, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies</p>
<p>4 Preclinical Pharmacokinetics of Flavonoids 161<br /> Jaime A. Yáñez, Casey L. Sayre, and Neal M. Davies</p>
<p>5 Clinical Pharmacokinetics of Flavonoids 195<br /> Casey L. Sayre, Karen D. Gerde, Jaime A. Yáñez, and Neal M. Davies</p>
<p>6 Toxicology and Safety of Flavonoids 249<br /> Stephanie E. Martinez, Neal M. Davies, and Jonathan K. Reynolds</p>
<p>7 Flavonoids and Drug Interactions 281<br /> Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, and Neal M. Davies</p>
<p>Index 321</p>