GQ Lin
John Wiley & Sons
e druk, 2011
9780470587201
Chiral Drugs – Chemistry and Biological Action
Chemistry and Biological Action
Specificaties
Gebonden, 472 blz.
|
Engels
John Wiley & Sons |
2011
ISBN13: 9780470587201
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Presenting an overview of chiral drugs and their impact on the pharmaceutical industry,
Chiral Drugs: Chemistry and Biological Action provides an integrated perspective of chiral drugs from concept, synthesis, and pharmaceutical properties. The book includes important chiral technologies and reviews of 200 chiral drugs that have either been approved or made it to advanced trials. It′s interdisciplinary approach combines synthetic organic chemistry, medicinal chemistry, and pharmacology in a way that fosters cooperation among interdisciplinary scientists and researchers in both academia and the pharma or biotech industries.
Specificaties
Inhoudsopgave
ABOUT THE EDITORS vii
<p>CONTRIBUTORS ix</p>
<p>INTRODUCTION 1</p>
<p>1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3<br /> Guo–Qiang Lin, Jian–Ge Zhang, and Jie–Fei Cheng</p>
<p>2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29<br /> Guo–Qiang Lin and Xing–Wen Sun</p>
<p>3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77<br /> Jianqiang Wang and Wenya Lu</p>
<p>4 RESOLUTION OF CHIRAL DRUGS 137<br /> Qi–Dong You</p>
<p>5 FLUORINE–CONTAINING CHIRAL DRUGS 195<br /> Xiao–Long Qiu, Xuyi Yue, and Feng–Ling Qing</p>
<p>6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253<br /> Hui–Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao–Ying Ni</p>
<p>7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297<br /> Deping Wang and Eric Hu</p>
<p>8 PHARMACOLOGY OF CHIRAL DRUGS 323<br /> Yongge Liu and Xiao–Hui Gu</p>
<p>9 PHARMACOKINETICS OF CHIRAL DRUGS 347<br /> Hanqing Dong, Xiaochuan Guo and Zengbiao Li</p>
<p>10 TOXICOLOGY OF CHIRAL DRUGS 381<br /> Guang Yang and Hai–Zhi Bu</p>
<p>11 REPRESENTATIVE CHIRAL DRUGS 401<br /> Jiangqin Sun, Dingguo Liu, and Zhimin Wang</p>
<p>INDEX 449</p>
<p>CONTRIBUTORS ix</p>
<p>INTRODUCTION 1</p>
<p>1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3<br /> Guo–Qiang Lin, Jian–Ge Zhang, and Jie–Fei Cheng</p>
<p>2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29<br /> Guo–Qiang Lin and Xing–Wen Sun</p>
<p>3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77<br /> Jianqiang Wang and Wenya Lu</p>
<p>4 RESOLUTION OF CHIRAL DRUGS 137<br /> Qi–Dong You</p>
<p>5 FLUORINE–CONTAINING CHIRAL DRUGS 195<br /> Xiao–Long Qiu, Xuyi Yue, and Feng–Ling Qing</p>
<p>6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253<br /> Hui–Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao–Ying Ni</p>
<p>7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297<br /> Deping Wang and Eric Hu</p>
<p>8 PHARMACOLOGY OF CHIRAL DRUGS 323<br /> Yongge Liu and Xiao–Hui Gu</p>
<p>9 PHARMACOKINETICS OF CHIRAL DRUGS 347<br /> Hanqing Dong, Xiaochuan Guo and Zengbiao Li</p>
<p>10 TOXICOLOGY OF CHIRAL DRUGS 381<br /> Guang Yang and Hai–Zhi Bu</p>
<p>11 REPRESENTATIVE CHIRAL DRUGS 401<br /> Jiangqin Sun, Dingguo Liu, and Zhimin Wang</p>
<p>INDEX 449</p>