PJ Scott
John Wiley & Sons
0e druk, 2012
9780470588956
Radiochemical Syntheses V1 Radiopharmaceuticals for Positron Emission Tomography
Radiopharmaceuticals for Positron Emission Tomography
Specificaties
Gebonden, 368 blz.
|
Engels
John Wiley & Sons |
2012
ISBN13: 9780470588956
Rubricering
Onderdeel van serie
Wiley Series on Radiochemical Syntheses
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
The ultimate reference guide to the synthesis of radiopharmaceuticals
The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step–by–step guidance on how to replicate these syntheses in the laboratory.
Volume 1 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today. It brings together in one complete, self–contained volume a collection of monographs containing a wealth of practical information from across the literature, demonstrating in meticulous detail how to prepare radiopharmaceuticals for positron emission tomography (PET) imaging, especially in tumor studies, cardiology, and neuroscience.
Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.
Specificaties
ISBN13:9780470588956
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:368
Uitgever:John Wiley & Sons
Druk:0
Inhoudsopgave
Contributors ix
<p>Foreword xvii</p>
<p>Preface xix</p>
<p>Abbreviations xxi</p>
<p>Part 1: Fluorine–18 Labeled Radiopharmaceuticals 1</p>
<p>Chapter 1: Synthesis of [<sup>18</sup>F]Fluorodeoxyglucose ([<sup>18</sup>F]FDG) 3<br /> Michelle Richards and Peter J. H. Scott</p>
<p>Chapter 2: Synthesis of [<sup>18</sup>F]Sodium Fluoride ([<sup>18</sup>F]NaF) 15<br /> Brian Hockley and Peter J. H. Scott</p>
<p>Chapter 3: Radiosynthesis of 3′–Deoxy–3′–[<sup>18</sup>F]Fluorothymidine ([<sup>18</sup>F]FLT) 21<br /> Hartmuth C. Kolb, Henry Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Peter J. H. Scott and Joseph C. Walsh</p>
<p>Chapter 4: Synthesis of [<sup>18</sup>F]Fluoroazomycin arabinoside (<sup>18</sup>F–FAZA) 31<br /> Brian G. Hockley and Peter J. H. Scott</p>
<p>Chapter 5: Synthesis of [<sup>18</sup>F]Fluoromisonidazole (1–(2–Hydroxy–3–[<sup>18</sup>F]fluoropropyl)–2–nitroimidazole, [<sup>18</sup>F]FMISO) 41<br /> Patrick J. Riss, Valentina Ferrari, Robbie Bielik, Roberto Canales–Candela, Rob Smith, and Franklin I. Aigbirhio</p>
<p>Chapter 6: Synthesis of [<sup>18</sup>F]FPPRGD2 51<br /> Shuanglong Liu, Frederick T. Chin, Zhen Cheng and Xiaoyuan Chen</p>
<p>Chapter 7: Synthesis of [<sup>18</sup>F]Fluorocholine ([<sup>18</sup>F]FCH) 61<br /> David Kryza</p>
<p>Chapter 8: Clinical Manufacturing of [<sup>18</sup>F]–16–a–Fluoroestradiol ([<sup>18</sup>F]FES) 69<br /> Piyush Kumar and John R. Mercer</p>
<p>Chapter 9: Synthesis of N–Succinimidyl 4–[<sup>18</sup>F]Fluorobenzoate ([<sup>18</sup>F]SFB) 81<br /> Xia Shao</p>
<p>Chapter 10: synthesis of 4–(2´–Methoxyphenyl)–1–[2′–(N–2′′–pyridinyl)–p–[<sup>18</sup>F]fluorobenzamido]ethylpiperazine ([<sup>18</sup>F]MPPF) 87<br /> Marion Alvarez and Didier Le Bars</p>
<p>Chapter 11: Synthesis of [<sup>18</sup>F]Fallypride 95<br /> Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio</p>
<p>Chapter 12: Synthesis of [<sup>18</sup>F]Fluoroethyltyrosine ([<sup>18</sup>F]FET) 103<br /> Y. Zhao, A. Alfteimi and M. Zuhayra</p>
<p>Chapter 13: Synthesis of [<sup>18</sup>F]Flumazenil ([<sup>18</sup>F]FZ) 111<br /> Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, Alexander Thiel</p>
<p>Chapter 14: Synthesis of 6–[<sup>18</sup>F]Fluorodopamine (6–[<sup>18</sup>F]FDA) 125<br /> Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz</p>
<p>Chapter 15: Synthesis of 2–([<sup>18</sup>F]fluoro)–3–[(2S)–2–Azetidinylmethoxy]Pyridine ([<sup>18</sup>F]2FA) 139<br /> Hayden T. Ravert, Daniel P. Holt and Robert F. Dannals</p>
<p>Chapter 16: Synthesis of [<sup>18</sup>F]–Substance–P Antagonist–receptor Quantifier ([<sup>18</sup>F]SPA–RQ) 155<br /> Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy Bormans</p>
<p>Part 2: Carbon–11 Labeled Radiopharmaceuticals 167</p>
<p>Chapter 17: SYNTHESIS OF [<sup>11</sup>C]–Choline Chloride ([<sup>11</sup>C]CHL) 169<br /> Brian G. Hockley, Bradford Henderson and Xia Shao</p>
<p>Chapter 18: Synthesis of 2–(4–N–[<sup>11</sup>C]methylaminophenyl)–6–hydroxybenzothiazole ([<sup>11</sup>C]6–OH–BTA–1; [<sup>11</sup>C]PIB) 177<br /> Cécile Philippe, Markus Mitterhauser and Wolfgang Wadsak</p>
<p>Chapter 19: Synthesis of [<sup>11</sup>C]–Meta–hydroxyephedrine ([<sup>11</sup>C]MHED) 191<br /> Filippo Lodi, Assunta Carpinelli, Claudio Malizia and Stefano Boschi</p>
<p>Chapter 20: Synthesis of L–[methyl–<sup>11</sup>C]Methionine ([<sup>11</sup>C]MET) 199<br /> Amy L. Vavere and Scott E. Snyder</p>
<p>Chapter 21: Synthesis of (+)– –[<sup>11</sup>C]–Dihydrotetrabenazine ([<sup>11</sup>C]DTBZ) 213<br /> Michael R. Kilbourn</p>
<p>Chapter 22: Synthesis of [<sup>11</sup>C]Flumazenil([<sup>11</sup>C]FMZ) 221<br /> Roberto Canales–Candela, Patrick J. Riss and Franklin I. Aigbirhio</p>
<p>Chapter 23: Synthesis of [<sup>11</sup>C]–Hexadecanoic Acid ([<sup>11</sup>C]Palmitic Acid) 233<br /> Adam C. Runkle, Xia Shao and Peter J. H. Scott</p>
<p>Chapter 24: Synthesis of [O–Methyl–<sup>11</sup>C]Metomidate ([<sup>11</sup>C]MTO) 245<br /> István. Boros and Franklin I. Aigbirhio</p>
<p>Chapter 25: Synthesis of [<sup>11</sup>C]Carfentanil ([<sup>11</sup>C]CFN) 257<br /> Louis Tluczek and Xia Shao</p>
<p>Chapter 26: Synthesis of [carbonyl–<sup>11</sup>C]WAY–100635 265<br /> J. D. Andersson, S. Nag, R. Krasikova, V.W. Pike and C. Halldin</p>
<p>Chapter 27: Synthesis of [<sup>11</sup>C]Raclopride 275<br /> Xia Shao</p>
<p>Chapter 28: Synthesis of 3–Amino–4–[2–(N–Methyl–N–[<sup>11</sup>C]Methyl–Amino–Methyl)Phenylsulfanyl]–Benzonitrile ([<sup>11</sup>C]DASB) 285<br /> Daniela Haeusler, Markus Mitterhauser and Wolfgang Wadsak</p>
<p>Chapter 29: Synthesis of [<sup>11</sup>C]Acetate 297<br /> Filippo Lodi, Claudio Malizia and Stefano Boschi</p>
<p>Chapter 30: Synthesis of N–(2–[<sup>11</sup>C]Methoxybenzyl)–N–(4–Phenoxypyridin–3–yl)Acetamide ([<sup>11</sup>C]PBR28) 305<br /> Qi–Huang Zheng, Min Wang and Bruce H. Mock</p>
<p>Part 3: Other Radiopharmaceuticals 313</p>
<p>Chapter 31: Synthesis of [<sup>13</sup>N]Ammonia ([<sup>13</sup>N]NH<sub>3</sub>) 315<br /> Peter J. H. Scott</p>
<p>Chapter 32: Synthesis of [<sup>68</sup>Ga]Gallium DOTA–(TYR3)–Octreotide Acetate ([<sup>68</sup>Ga]DOTATOC) 321<br /> Harald Eidherr, Friedrich Girschele, Markus Mitterhauser and Wolfgang Wadsak</p>
<p>Appendix 1: Supplier Information 335</p>
<p>Index 339</p>
<p>Foreword xvii</p>
<p>Preface xix</p>
<p>Abbreviations xxi</p>
<p>Part 1: Fluorine–18 Labeled Radiopharmaceuticals 1</p>
<p>Chapter 1: Synthesis of [<sup>18</sup>F]Fluorodeoxyglucose ([<sup>18</sup>F]FDG) 3<br /> Michelle Richards and Peter J. H. Scott</p>
<p>Chapter 2: Synthesis of [<sup>18</sup>F]Sodium Fluoride ([<sup>18</sup>F]NaF) 15<br /> Brian Hockley and Peter J. H. Scott</p>
<p>Chapter 3: Radiosynthesis of 3′–Deoxy–3′–[<sup>18</sup>F]Fluorothymidine ([<sup>18</sup>F]FLT) 21<br /> Hartmuth C. Kolb, Henry Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Peter J. H. Scott and Joseph C. Walsh</p>
<p>Chapter 4: Synthesis of [<sup>18</sup>F]Fluoroazomycin arabinoside (<sup>18</sup>F–FAZA) 31<br /> Brian G. Hockley and Peter J. H. Scott</p>
<p>Chapter 5: Synthesis of [<sup>18</sup>F]Fluoromisonidazole (1–(2–Hydroxy–3–[<sup>18</sup>F]fluoropropyl)–2–nitroimidazole, [<sup>18</sup>F]FMISO) 41<br /> Patrick J. Riss, Valentina Ferrari, Robbie Bielik, Roberto Canales–Candela, Rob Smith, and Franklin I. Aigbirhio</p>
<p>Chapter 6: Synthesis of [<sup>18</sup>F]FPPRGD2 51<br /> Shuanglong Liu, Frederick T. Chin, Zhen Cheng and Xiaoyuan Chen</p>
<p>Chapter 7: Synthesis of [<sup>18</sup>F]Fluorocholine ([<sup>18</sup>F]FCH) 61<br /> David Kryza</p>
<p>Chapter 8: Clinical Manufacturing of [<sup>18</sup>F]–16–a–Fluoroestradiol ([<sup>18</sup>F]FES) 69<br /> Piyush Kumar and John R. Mercer</p>
<p>Chapter 9: Synthesis of N–Succinimidyl 4–[<sup>18</sup>F]Fluorobenzoate ([<sup>18</sup>F]SFB) 81<br /> Xia Shao</p>
<p>Chapter 10: synthesis of 4–(2´–Methoxyphenyl)–1–[2′–(N–2′′–pyridinyl)–p–[<sup>18</sup>F]fluorobenzamido]ethylpiperazine ([<sup>18</sup>F]MPPF) 87<br /> Marion Alvarez and Didier Le Bars</p>
<p>Chapter 11: Synthesis of [<sup>18</sup>F]Fallypride 95<br /> Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio</p>
<p>Chapter 12: Synthesis of [<sup>18</sup>F]Fluoroethyltyrosine ([<sup>18</sup>F]FET) 103<br /> Y. Zhao, A. Alfteimi and M. Zuhayra</p>
<p>Chapter 13: Synthesis of [<sup>18</sup>F]Flumazenil ([<sup>18</sup>F]FZ) 111<br /> Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, Alexander Thiel</p>
<p>Chapter 14: Synthesis of 6–[<sup>18</sup>F]Fluorodopamine (6–[<sup>18</sup>F]FDA) 125<br /> Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz</p>
<p>Chapter 15: Synthesis of 2–([<sup>18</sup>F]fluoro)–3–[(2S)–2–Azetidinylmethoxy]Pyridine ([<sup>18</sup>F]2FA) 139<br /> Hayden T. Ravert, Daniel P. Holt and Robert F. Dannals</p>
<p>Chapter 16: Synthesis of [<sup>18</sup>F]–Substance–P Antagonist–receptor Quantifier ([<sup>18</sup>F]SPA–RQ) 155<br /> Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy Bormans</p>
<p>Part 2: Carbon–11 Labeled Radiopharmaceuticals 167</p>
<p>Chapter 17: SYNTHESIS OF [<sup>11</sup>C]–Choline Chloride ([<sup>11</sup>C]CHL) 169<br /> Brian G. Hockley, Bradford Henderson and Xia Shao</p>
<p>Chapter 18: Synthesis of 2–(4–N–[<sup>11</sup>C]methylaminophenyl)–6–hydroxybenzothiazole ([<sup>11</sup>C]6–OH–BTA–1; [<sup>11</sup>C]PIB) 177<br /> Cécile Philippe, Markus Mitterhauser and Wolfgang Wadsak</p>
<p>Chapter 19: Synthesis of [<sup>11</sup>C]–Meta–hydroxyephedrine ([<sup>11</sup>C]MHED) 191<br /> Filippo Lodi, Assunta Carpinelli, Claudio Malizia and Stefano Boschi</p>
<p>Chapter 20: Synthesis of L–[methyl–<sup>11</sup>C]Methionine ([<sup>11</sup>C]MET) 199<br /> Amy L. Vavere and Scott E. Snyder</p>
<p>Chapter 21: Synthesis of (+)– –[<sup>11</sup>C]–Dihydrotetrabenazine ([<sup>11</sup>C]DTBZ) 213<br /> Michael R. Kilbourn</p>
<p>Chapter 22: Synthesis of [<sup>11</sup>C]Flumazenil([<sup>11</sup>C]FMZ) 221<br /> Roberto Canales–Candela, Patrick J. Riss and Franklin I. Aigbirhio</p>
<p>Chapter 23: Synthesis of [<sup>11</sup>C]–Hexadecanoic Acid ([<sup>11</sup>C]Palmitic Acid) 233<br /> Adam C. Runkle, Xia Shao and Peter J. H. Scott</p>
<p>Chapter 24: Synthesis of [O–Methyl–<sup>11</sup>C]Metomidate ([<sup>11</sup>C]MTO) 245<br /> István. Boros and Franklin I. Aigbirhio</p>
<p>Chapter 25: Synthesis of [<sup>11</sup>C]Carfentanil ([<sup>11</sup>C]CFN) 257<br /> Louis Tluczek and Xia Shao</p>
<p>Chapter 26: Synthesis of [carbonyl–<sup>11</sup>C]WAY–100635 265<br /> J. D. Andersson, S. Nag, R. Krasikova, V.W. Pike and C. Halldin</p>
<p>Chapter 27: Synthesis of [<sup>11</sup>C]Raclopride 275<br /> Xia Shao</p>
<p>Chapter 28: Synthesis of 3–Amino–4–[2–(N–Methyl–N–[<sup>11</sup>C]Methyl–Amino–Methyl)Phenylsulfanyl]–Benzonitrile ([<sup>11</sup>C]DASB) 285<br /> Daniela Haeusler, Markus Mitterhauser and Wolfgang Wadsak</p>
<p>Chapter 29: Synthesis of [<sup>11</sup>C]Acetate 297<br /> Filippo Lodi, Claudio Malizia and Stefano Boschi</p>
<p>Chapter 30: Synthesis of N–(2–[<sup>11</sup>C]Methoxybenzyl)–N–(4–Phenoxypyridin–3–yl)Acetamide ([<sup>11</sup>C]PBR28) 305<br /> Qi–Huang Zheng, Min Wang and Bruce H. Mock</p>
<p>Part 3: Other Radiopharmaceuticals 313</p>
<p>Chapter 31: Synthesis of [<sup>13</sup>N]Ammonia ([<sup>13</sup>N]NH<sub>3</sub>) 315<br /> Peter J. H. Scott</p>
<p>Chapter 32: Synthesis of [<sup>68</sup>Ga]Gallium DOTA–(TYR3)–Octreotide Acetate ([<sup>68</sup>Ga]DOTATOC) 321<br /> Harald Eidherr, Friedrich Girschele, Markus Mitterhauser and Wolfgang Wadsak</p>
<p>Appendix 1: Supplier Information 335</p>
<p>Index 339</p>