Human Genetics and Genomics, 4th Edition
Includes Wiley E–Text
Samenvatting
This fourth edition of the best–selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions.
A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice.
Now featuring full–color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today s genetics teaching, and includes updated discussion of genetic risk assessment, single gene disorders and therapeutics.
Key learning features include:
Clinical snapshots to help relate science to practice
Hot topics boxes that focus on the latest developments in testing, assessment and treatment
Ethical issues boxes to prompt further thought and discussion on the implications of genetic developments
Sources of information boxes to assist with the practicalities of clinical research and information provision
Self–assessment review questions in each chapter
Accompanied by the Wiley E–Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including:
Factsheets on 100 genetic disorders, ideal for study and exam preparation
Interactive Multiple Choice Questions (MCQs) with feedback on all answers
Links to online resources for further study
Figures from the book available as PowerPoint slides, ideal for teaching purposes
The perfect companion to the genetics component of both problem–based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio–molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast–moving discipline.
Specificaties
Inhoudsopgave
<p>How to get the best out of your textbook viii</p>
<p>PART ONE: BASIC PRINCIPLES OF HUMAN GENETICS 1</p>
<p>1 DNA Structure and Function 3</p>
<p>2 Genetic Variation 20</p>
<p>3 Patterns of Inheritance 38</p>
<p>4 The Human Genome 64</p>
<p>5 Multifactorial Inheritance 87</p>
<p>6 Cell Division and Chromosomes 100</p>
<p>7 Population Genetics 125</p>
<p>8 Cancer Genetics 137</p>
<p>PART TWO: GENETICS AND GENOMICS IN MEDICAL PRACTICE 155</p>
<p>9 Chromosome Translocation 157</p>
<p>10 Molecular Diagnosis 171</p>
<p>11 Newborn Screening 182</p>
<p>12 Developmental Genetics 194</p>
<p>13 Carrier Screening 203</p>
<p>14 Genetic Risk Assessment 213</p>
<p>15 Genetic Testing for Risk of Cancer 222</p>
<p>16 Pharmacogenetics 230</p>
<p>17 Treatment of Genetic Disorders 239</p>
<p>Answers to Review Questions 248</p>
<p>Glossary 253</p>
<p>Index 262 </p>