Part I. Biological Perspectives: 1. Nonhuman primate models of memory dysfunction in neurodegenerative disease: contributions from comparative neuropsychology Marlene Oscar-Berman, Fiona Bardenhagen; 2. Non-primate animal models of motor and cognitive dysfunction associated with Huntington's Disease Raymond P. Kesner, J. Vincent Filoteo; 3. Neuropathology and memory dysfunction in neurodegenerative diseases Julie A. Testa, Roger A. Brumback, Tai-Kyoung Baik, Richard W. Leech, Thomas C. Cannon; 4. Neurochemical aspects of memory dysfunction in neurodegenerative disease Edison Miyawaki, William C. Koller; 5. Structural neuroimaging correlates of memory dysfunction in neurodegenerative disease Edith V. Sullivan, Deborah A. Cahn, Rosemary Fama, Paula K. Shear; 6. Functional neuroimaging correlates of memory dysfunction in neurodegenerative disease Stanley Berent, Bruno Giordani; Summary: 7. The biology of neurodegenerative diseases Hans J. Markowitsch; Part II. Cognitive Perspectives: 8. The role of executive deficits in memory disorders in neurodegenerative disease Adrian M. Owen, Barbara J. Sahakian, Trevor W. Robbins; 9. Prospective memory in aging and neurodegenerative disease Robert G. Knight; 10. Remote memory in neurodegenerative disease Robert H. Paul, Joni R. Graber, David C. Bowlby, Julie A. Testa, Michael J. Harnish, William W. Beatty; 11. Semantic memory in neurodegenerative disease Joseph W. Fink, Christopher Randolph; 12. Non-declarative memory in neurodegenerative disease David P. Salmon, Tara T. Lineweaver, William C. Heindel; Summary: 13. Memory in neurodegenerative disease: what has been learnt about the organization of memory? Andrew R. Mayes; Part III. Clinical Perspectives: 14. Biological and psychosocial risk factors for dementia and memory loss Diane M. Jacobs, Peter Schofield; 15. Cross-cultural issues in the neuropsychological assessment of neurodegenerative disease Andreas U. Monsch, Kirsten I. Taylor, Mark W. Bondi; 16. Psychometric issues in the clinical assessment of memory in aging and neurodegenerative disease Anthony M. Paolo; 17. The role of memory assessment in the preclinical detection of dementia Mark W. Bondi, Andreas U. Monsch; 18. Clinical differentiation of memory disorders in neurodegenerative disease Kathleen A. Welsh-Bohmer, Paula K. Ogrocki; 19. The impact of depression on memory in neurodegenerative disease Julie A. Fields, Suzanne Norman, Kristy A. Straits-Tröster, Alexander I. Tröster; 20. Preserved cognitive skills in dementia Joni R. Graber, Robert H. Paul, Julie A. Testa, David C. Bowlby, Michael J. Harnish, William W. Beatty; 21. Drug treatment of cognitive impairment in neurodegenerative diseases: rationale, current experience, and expectations for the future Louis T. Giron, Jr., William C. Koller; 22. Surgical interventions in neurodegenerative disease: impact on memory and cognition Steven B. Wilkinson, Alexander I. Tröster; 23. Memory dysfunction in neurodegenerative disease: ethical and legal issues Martin D. Zehr; Summary: 24. Memory in neurodegenerative disease: clinical perspectives Thomas Benke.