Foreword N. Skakkeback; Part I. Introduction: 1. Physiological regulators of growth hormone secretion M. L. Hartman; 2. Insulin-like Growth Factors (IGF) and their IGF-binding proteins - their use for diagnosis of growth hormone deficiency W. F. Blum; 3. Growth hormone and IGF-I effects on in-vivo substrate metabolism in humans N. Møller; 4. Determination of growth hormone and GHBP in serum S. Fisker and H. Ørskov; Part II. Diagnostic and Clinical Aspects: 5. The syndrome of growth hormone deficiency in adults R. Cuneo, F. Salomon and P. H. Sönkse; 6. The diagnosis of growth hormone deficiency in adults D. M. Hoffman and K. K. Y. Ho; 7. Monitoring of growth hormone replacement therapy A. A. Toogood, S. J. Howell and S. M. Shalet; Part III. Growth Hormone Replacement Therapy in Adults with Growth Hormone Deficiency: 8. The effect of growth hormone on protein metabolism D. L. Russell-Jones and M. Umpleby; 9. Growth hormone deficiency, insulin resistance and glucose metabolism F. L. Hew, M. C. Christopher and F. P. Alford; 10. Growth hormone and body composition J. S. Christiansen and N. Vahl; 11. Effects of growth hormone on fluid homeostasis J. Møller; 12. Growth hormone and cardiac function A. Cittadini, S. Longobardi, S. Fazio and L. Sacià; 13. Growth hormone and cardiovascular risk factors T. Rosen; 14. Growth hormone and exercise performance muscle strength and sweat production in healthy subjects and in adults with growth hormone deficiency A. Juul, K. Main and N. E. Skakkebaek; 15. Growth hormone and bone and mineral metabolism J-M. Kaufman and M. Vandeweghe; 16. Growth hormone and thyroid function and energy expenditure J. O. L. Jørgensen, T. Wolthers and J. Weeke; 17. Growth hormone and psychosocial and central nervous effects J.-O. Johansson, L. Wirén and B.-Å. Bengtsson; 18. Impact of gender and age on growth hormone responsiveness P. Burman and G. Johannsson; Part IV. Growth Hormone, Growth-hormone Releasing Peptides and Ageing: 19. Growth hormone and ageing K. G. O'Connor and M. R. Blackman; 20. Growth hormone releasing substances - basic aspects K. K. McKee, A. D. Howard, S. D. Feighner, S. Pony and R. G. Smith; 21. Clinical uses of growth hormone releasing peptides (GHRPs) and GHPR analogues in adults I. M. Chapman and M. O. Thorner; Index.