<p>Section 1: Early Fetal Development</p> <p>1 Early Concepts and Terminology, 2</p> <p>Patricia Collins</p> <p>2 Cellular Mechanisms and Embryonic Tissues, 6</p> <p>Patricia Collins</p> <p>3 Staging Embryos in Development and the</p> <p>Embryonic Body Plan, 23</p> <p>Patricia Collins</p> <p>4 Teratology, 30</p> <p>Sarah G. Obican and Anthony R. Scialli</p> <p>5 Early Pregnancy Failure, 38</p> <p>Davor Jurkovic and Kuhan Rajah</p> <p>Section 2: The Placenta</p> <p>6 The Immunology of Implantation, 48</p> <p>Ashley Moffett, Y.W. Loke and Andrew Sharkey</p> <p>7 Development of the Placenta and Its</p> <p>Circulation, 55</p> <p>Caroline E. Dunk, Berthold Huppertz and John C. Kingdom</p> <p>8 Placental Function in Maternofetal</p> <p>Exchange, 69</p> <p>Colin Sibley and Mark Dilworth</p> <p>9 Placental Pathology and Implications for Fetal</p> <p>Medicine, 78</p> <p>Neil J. Sebire and John C. Kingdom</p> <p>Section 3: Fetal Physiology and Pathology</p> <p>10 Development of the Heart and Cardiovascular</p> <p>System in Relation to Cardiac Abnormalities, 88</p> <p>Michael Ashworth</p> <p>11 Lung Growth and Maturation, 103</p> <p>Richard Harding, Annie R.A. McDougall and Stuart B. Hooper</p> <p>12 Development of the Kidneys and Urinary Tract in</p> <p>Relation to Renal Anomalies, 114</p> <p>Paul J.D. Winyard</p> <p>13 The Perinatal Postmortem Examination, 121</p> <p>J. Ciaran Hutchinson, Susan C. Shelmerdine and Neil J. Sebire</p> <p>Section 4: Epidemiology</p> <p>14 Epidemiologic and Research Methods in Fetal</p> <p>Medicine, 132</p> <p>Cande V. Ananth and Alan T. Tita</p> <p>Section 5: Ethics</p> <p>15 Ethical Issues in Maternal-Fetal Medicine, 139</p> <p>Wybo J. Dondorp and Guido M. de Wert</p> <p>Section 6: Prenatal Screening and Diagnosis</p> <p>16 Principles of Screening, 149</p> <p>Joshua I. Rosenbloom and George A. Macones</p> <p>17 Conveying Information About Screening and</p> <p>Diagnosis, 154</p> <p>Jenny Hewison, Louise D. Bryant and Jane Fisher</p> <p>18 Ultrasound and Biochemical Screening for Fetal</p> <p>Aneuploidy, 161</p> <p>Howard Cuckle and Ran Neiger</p> <p>19 Ultrasound Screening for Fetal Abnormalities in</p> <p>the First Trimester, 176</p> <p>Caterina M. Bilardo and Frederick Ushakov</p> <p>20 Evidence for Routine Ultrasound Screening for</p> <p>Fetal</p> <p>Abnormalities in the Second and Third</p> <p>Trimesters,</p> <p>194</p> <p>Yalda Afshar, Rashmi Rao, Anahit Martirosian and</p> <p>Lawrence D. Platt</p> <p>21 Noninvasive Screening for Cytogenetic Disorders</p> <p>(Fetal Aneuploidy Including Microdeletions), 202</p> <p>Karen Wou and Ronald J. Wapner</p> <p>22 Noninvasive Prenatal Diagnosis for Single-Gene</p> <p>Disorders, 214</p> <p>Melissa Hill and Lyn S. Chitty</p> <p>Contents</p> <p>Contents vii</p> <p>23 Invasive Diagnostic Procedures, 225</p> <p>Anthony O. Odibo and Ganesh Acharya</p> <p>24 Prenatal Diagnosis of Chromosome</p> <p>Abnormalities, 233</p> <p>Colleen G. Bilancia, Mythily Ganapathi and Brynn Levy</p> <p>25 Advances in Molecular Genetics Including Fetal</p> <p>Sequencing, 247</p> <p>Magdalena Walkiewicz and Ignatia B. Van den Veyver</p> <p>26 Expanded Carrier Screening, 254</p> <p>Liran Hiersch and Yuval Yaron</p> <p>27 Prenatal Screening for Thalassemias, 263</p> <p>Kwok Yin Leung, Patrick Au and Mary Tang</p> <p>Section 7: Diagnosis and Management of</p> <p>Fetal Malformations</p> <p>28 Sonography of the Fetal Central Nervous</p> <p>System, 275</p> <p>Luc De Catte, Bart De Keersmaecker, Luc Joyeux and</p> <p>Michael Aertsen</p> <p>29 The Heart, 305</p> <p>Christoph Wohlmuth and Helena M. Gardiner</p> <p>30 Fetal Lung Lesions, 324</p> <p>James Cook, Angela Yulia, Colin Wallis and Pranav P. Pandya</p> <p>31 Congenital Diaphragmatic Hernia, 332</p> <p>Francesca Maria Russo, Liesbeth Lewi, Jute Richter and</p> <p>Jan Deprest</p> <p>32 Abdomen, 340</p> <p>Jon Hyett</p> <p>33 Kidney and Urinary Tract Disorders, 351</p> <p>Roland Devlieger and An Hindryckx</p> <p>34 Diagnosis and Management of Fetal Skeletal</p> <p>Abnormalities,</p> <p>373</p> <p>Lyn S. Chitty, Louise C. Wilson and Frederick Ushakov</p> <p>35 Diagnosis and Management of Abnormalities of</p> <p>the Face, 402</p> <p>Elisabeth de Jong-Pleij and Caterina M. Bilardo</p> <p>36 Fetal Hydrops, 427</p> <p>Sylvie Langlois and R. Douglas Wilson</p> <p>37 Fetal Tumours, 443</p> <p>Thomas R. Everett, Rosalind Pratt, Colin R. Butler, Richard J.</p> <p>Hewitt, Paolo De Coppi and Pranav P. Pandya</p> <p>38 Open Fetal Surgery, 454</p> <p>Luc Joyeux, Frank Van Calenbergh, Roland Devlieger,</p> <p>Luc De Catte and Jan Deprest</p> <p>Section 8: Diagnosis and Management of</p> <p>Other Fetal Conditions</p> <p>39 Fetal Growth and Growth Restriction, 469</p> <p>Emily J. Su and Henry L. Galan</p> <p>40 Haemolytic Disease of the Fetus and Newborn, 484</p> <p>Saul Snowise and Kenneth J. Moise Jr.</p> <p>41 Fetal Platelet Disorders, 497</p> <p>Dian Winkelhorst and Dick Oepkes</p> <p>42 Fetal Infections, 508</p> <p>Guillaume Benoist, Marianne Leruez-Ville and Yves Ville</p> <p>43 Disorders of Amniotic Fluid, 526</p> <p>Jan E. Dickinson</p> <p>44 Multiple Pregnancy, 532</p> <p>Sieglinde M. Müllers, Fionnuala McAuliffe and Fergal D. Malone</p> <p>45 In Utero Stem Cell Transplantation, 554</p> <p>Cecilia Götherström, Lilian Walther-Jallow and Magnus Westgren</p> <p>46 Fetal Gene Therapy, 560</p> <p>Anna L. David</p> <p>47 The Developmental Origins of Health and</p> <p>Disease, 572</p> <p>Scott W. White, Sara L. Hillman and John P. Newnham</p> <p>Section 9: Interface of Maternal, Fetal and</p> <p>Neonatal Medicine</p> <p>48 Pharmacokinetics and Pharmacodynamics, 581</p> <p>Lara S. Lemon, Raman Venkataramanan and Steve N. Caritis</p> <p>49 Neonatal Management and Outcome in Extreme</p> <p>Prematurity, 588</p> <p>Enrico Lopriore, Arjan B. Te Pas, Sylke Steggerda and</p> <p>Jeanine M. van Klink</p> <p>Online Materials</p> <p>Self-Assessment</p> <p>Spyros Bakalis, Frederick Ushakov and Pranav P. Pandya</p> <p>Index, 597</p>
