Evolution of Virulence in Eukaryotic Microbes
Samenvatting
A unique and timely review of the emergence of eukaryotic virulence in fungi, oomycetes, and protozoa, as they affect both animals and plants
Evolution of Virulence in Eukaryotic Microbes addresses new developments in defining the molecular basis of virulence in eukaryotic pathogens. By examining how pathogenic determinants have evolved in concert with their hosts, often overcoming innate and adaptive immune mechanisms, the book takes a fresh look at the selective processes that have shaped their evolution.
Introductory chapters ground the reader in principal evolutionary themes such as phylogenetics and genetic exchange, building a basis of knowledge for later chapters covering advances in genetic tools, how pathogens exchange genetic material in nature, and the common themes of evolutionary adaptation that lead to disease in different hosts.
With the goal of linking the research findings of the many disparate scientific communities in the field, the book:
Assembles for the first time a collection of chapters on the diversity of eukaryotic microorganisms and the influence of evolutionary forces on the origins and emergence of their virulent attributes
Highlights examples from three important, divergent groups of eukaryotic microorganisms that cause disease in animals and plants: oomycetes, protozoan parasites, and fungi
Covers how the development of genetic tools has fostered the identification and functional analyses of virulence determinants
Addresses how pathogens exchange genetic material in nature via classical or modified meiotic processes, horizontal gene transfer, and sexual cycles including those that are cryptic or even unisexual
Provides a broad framework for formulating future studies by illustrating themes common to different pathogenic microbes
Evolution of Virulence in Eukaryotic Microbes is an ideal book for microbiologists, evolutionary biologists and medical professionals, as well as graduate students, postdoctoral fellows, and faculty members working on the evolution of pathogens.
Specificaties
Inhoudsopgave
<p>ACKNOWLEDGMENTS xi</p>
<p>CONTRIBUTORS xiii</p>
<p>PART I GENERAL OVERVIEWS 1</p>
<p>1 Population Genetics and Parasite Diversity 3<br />Hsiao–Han Chang, Rachel F. Daniels, and Daniel L. Hartl</p>
<p>2 Evolution of Meiosis, Recombination, and Sexual Reproduction in Eukaryotic Microbes 17<br />Wenjun Li, Elizabeth Savelkoul, Joseph Heitman, and John M. Logsdon, Jr.</p>
<p>3 Phylogenomic Analysis 44<br />Andrew J. Roger, Martin Kolisko, and Alastair G. B. Simpson</p>
<p>4 Phylogenetics and Evolution of Virulence in the Kingdom Fungi 70<br />Monica A. Garcia–Solache and Arturo Casadevall</p>
<p>PART II POPULATION GENETICS AND EVOLUTIONARY APPROACHES 91</p>
<p>5 Malaria: Host Range, Diversity, and Speciation 93<br />Ananias A. Escalante and Francisco J. Ayala</p>
<p>6 From Population Genomics to Elucidated Traits in Plasmodium Falciparum 111<br />Sarah K. Volkman, Daniel E. Neafsey, Stephen F. Schaffner, Pardis C. Sabeti, and Dyann F. Wirth</p>
<p>7 Selective Sweeps in Human Malaria Parasites 124<br />Xin–zhuan Su and John C. Wootton</p>
<p>8 Evolution of Drug Resistance in Fungi 143<br />Jessica A. Hill, Samantha J. Hoot, Theodore C. White, and Leah E. Cowen</p>
<p>9 Discovery of Extant Sexual Cycles in Human Pathogenic Fungi and Their Roles in the Generation of Diversity and Virulence 168<br />Richard J. Bennett and Kirsten Nielsen</p>
<p>10 Worldwide Migrations, Host Shifts, and Reemergence of Phytophthora Infestans, the Plant Destroyer 192<br />Jean Beagle Ristaino</p>
<p>11 Experimental and Natural Evolution of the Cryptococcus Neoformans and Cryptococcus Gattii Species Complex 208<br />Alexander Idnurm and Jianping Xu</p>
<p>12 Population Genetics, Diversity, and Spread of Virulence in Toxoplasma Gondii 231<br />Benjamin M. Rosenthal and James W. Ajioka</p>
<p>PART III FORWARD AND REVERSE GENETIC SYSTEMS FOR DEFINING VIRULENCE 247</p>
<p>13 Genetic Crosses in Plasmodium Falciparum: Analysis of Drug Resistance 249<br />John C. Tan and Michael T. Ferdig</p>
<p>14 Genetic Mapping of Virulence in Rodent Malarias 269<br />Richard Carter and Richard Culleton</p>
<p>15 Genetic Mapping of Acute Virulence in Toxoplasma Gondii 285<br />L. David Sibley and John C. Boothroyd</p>
<p>16 Virulence in African Trypanosomes: Genetic and Molecular Approaches 307<br />Annette Macleod, Liam J. Morrison, and Andy Tait</p>
<p>17 The Evolution of Antigenic Variation in African Trypanosomes 324<br />Andrew P. Jackson and J. David Barry</p>
<p>18 Antigenic Variation, Adherence, and Virulence in Malaria 338<br />Joseph Smith and Kirk W. Deitsch</p>
<p>19 Invasion Ligand Diversity and Pathogenesis in Blood–Stage Malaria 362<br />Manoj T. Duraisingh, Jeffrey D. Dvorin, and Peter R. Preiser</p>
<p>PART IV COMPARATIVE "OMICS" APPROACHES TO DEFINING VIRULENCE 385</p>
<p>20 Evolution of Virulence in Oomycete Plant Pathogens 387<br />Paul R. J. Birch, Mary E. Coates, and Jim L. Beynon</p>
<p>21 Evolution and Genomics of the Pathogenic Candida Species Complex 404<br />Geraldine Butler, Michael Lorenz, and Neil A. R. Gow</p>
<p>22 Evolution of Entamoeba Histolytica Virulence 422<br />Upinder Singh and Christopher D. Huston</p>
<p>23 Sex and Virulence in Basidiomycete Pathogens 437<br />Guus Bakkeren, Emilia K. Kruzel, and Christina M. Hull</p>
<p>24 Emergence of the Chytrid Fungus Batrachochytrium Dendrobatidis and Global Amphibian Declines 461<br />Matthew C. Fisher, Jason E. Stajich, and Rhys A. Farrer</p>
<p>25 Impact of Horizontal Gene Transfer on Virulence of Fungal Pathogens of Plants 473<br />Barbara J. Howlett and Richard P. Oliver</p>
<p>26 Evolution of Plant Pathogenicity in Fusarium Species 485<br />Li–Jun Ma, H. Corby Kistler, and Martijn Rep</p>
<p>27 Genetic, Genomic, and Molecular Approaches to Define Virulence of Aspergillus Fumigatus 501<br />Laetitia Muszkieta, William J. Steinbach, and Jean–Paul Latge</p>
<p>28 Cryptosporidium: Comparative Genomics and Pathogenesis 518<br />Satomi Kato and Jessica C. Kissinger</p>
<p>INDEX 545</p>