List of principal contributors List of chairpersons Preface SECTION I: METABOLISM AND TRANSPORT OF BILE ACIDS.- 1 Membrane asymmetry and the regulation of bile formation.- 2 ATP8B1, a phosphatidylserine flippase deficient in inherited intrahepatic cholestasis.- 3 Fic1-deficient rat hepatocytes reveal structural and functional defects in the bile canalicular membrane when exposed to hydrophobic bile acids.- 4 Bile acids and the brain: suggested pathogenetic mechanism in connection with formation of brain xanthomas in patients with cerebrotendinous xanthomatosis.- SECTION II: TRANSPORT OF BILE ACIDS.- 5 Canalicular microdomains and bile formation.- 6 Regulation of the cell surface expression and transport capacity of bile salt export pump by small chemical molecules.- 7 The role of ABCB11 (BSEP) variation in susceptibility to intrahepatic cholestasis of pregnancy.- 8 Intracellular transport of bile salts.- 9 Conjugated bile acids regulate hepatic gluconeogenic genes via G&agr;i protein-coupled receptor(s) and the insulin signalling pathway.- SECTION III: TRANSPORT AND ACTIONS OF BILE ACIDS.- 10 Role of the organic solute transporter Ost&agr;-Ost&bgr; in intestinal basolateral bile acid transport and bile acid homeostasis.- 11 Mechanisms of regulation of bile acid transport in the small intestine.- 12 Expression and localization of the membrane-bound bile acid receptor TGR5 in human gallbladder tissue.- 13 Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium.- 14 From Glarus to Gallenfarbstoffen: the scientific contributions of Rudi Schmid.- SECTION IV: NUCLEAR RECEPTOR REGULATION.- 15 Nuclear receptor regulation of bile acid transporters.- 16 Novel roles of liver X receptor in bile acid homeostasis and haptobiliary diseases.- 17 The nuclear hormone receptor Er&agr; plays a critical role in determining estrogen-induced cholesterol gallstones.-18 Role of intestinal nuclear bile acid receptor FXR in the gut–liver axis.- SECTION V: BILE ACIDS AS METABOLIC INTEGRATORS.- 19 Linking nutrition and metabolism, a role for the membrane bile acid receptor TGR5.- 20 Potential role of ursodeoxycholic acid and its side-chain modified derivatives in the treatment of non-alcoholic fatty liver disease and associated atherosclerosis.- 21 Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout mice.- 22.- Role of side-chain amidation for the anticholestatic action of norursodeoxycholic acid in rat liver.- 23 Adolf Windhaus Prize Lecture: A central role for the organic solute and steroid transporter, Ost&agr;-Ost&bgr;, in the enterohepatic circulation of bile acids and structurally related molecules.- SECTION VI: BILE ACIDS: CELLULAR INJURY AND REGENERATION.- 24 Pro- and antiapoptotic actions of bile acids and CD95 ligand in hepatic stellate cells.- 25 Reactivation of hepatic organic anion transporters in different forms of acquired cholestasis by nuclear hormone receptor activators.- 26 Interactions between neuropeptides and bile acids in the modulation of cholangiocyte biology.- SECTION VII: BILE ACID-RELATED GENETIC LIVER DISEASE.- 27 The many faces of ABCB4 deficiency: the relevance of canalicular membrane-transporting proteins for human liver disease.- 28 Severe bile salt export pump (BSEP) deficiency: mutations, immunohistochemically assessed BSEP expression, and malignancy risk.- 29 Role of genetics in drug-induced liver injury.- 30 Variability of cholestatic liver disease in a family with an ABCB4 defect: ABCB4 mutation in 11 siblings.- 31 ABCG5/G8 as a human risk gene for cholesterol gallstone disease.- 32 ATP8B1 deficiency: general background, clinical manifestations and possible therapeutic interventions.- 33 Bile acid abnormalities in p
