1. CNIDARIAN IMMUNITY: A TALE OF TWO BARRIERSRené Augustin and Thomas C.G. BoschAbstractIntroduction: Cnidaria Provide Information about the Evolution of ImmunityCnidarian Immune Responses Are Performed by Two Epithelial BarriersCnidarians Do Not Live Alone but Are Intimately Associated with SymbiontsCnidarians Recognize Microbial Associated Molecular Patterns through Germ - Line Encoded Pattern Recognition Receptors (PRs)Cnidarians Produce Antimicrobial Peptides Which - Are Effective Even Against Human PathogensHow Do Cnidaria Distinguish Self from Nonself?Concluson and Perspective—Where Will the Tale Lead Us?2. GASTROPOD IMMUNOBIOLOGYEric S. LokerAbstractIntroduction: An Homage to Gastropod Antiquity and DiversityInfectious Challenges to GastropodsGastropod Genome Projects—Awaiting the DelugeThe Distinctive Architecture of Gastropod Immune Systems Offers ManyOpportunities for StudySnails and Digeneans as Models to Study Specific, Intimate and Long?Term. Host?Parasite SystemsAddressing Fundamental Issues in Immunology Using Gastropod ModelsOpportunities to Expand the Relevance of Gastropod ImmunityConclusion3. BIVALVE IMMUNITYLinsheng Song, Lingling Wang, Limei Qiu and Huan ZhangAbstractIntroductionHemocytes and PhagocytosisImmuneRecognitionImmunity Signaling PathwaysImmune EffectorConclusion4. EARTHWORM IMMUNITYMartin Bilej, Petra Procházková, Marcela Šilerová and Radka JoskováAbstractIntroductionBasic Information on Earthworm AnatomyCellular Defense MechanismsHumoral Defense MechanismsConclusion5. LECH IMMUNITY: FROM BRAIN TO PERIPHERAL - RESPONSESAurélie Tasiemski and Michel SalzetAbstractIntroductionThe Medicinal Leech as a Model for Studying the Immune Response of the CNSB/Theromyzon Tessulatum as a Model for Studying the Peripheral Immune ResponseConclusion and Perspectives6. INNATE IMMUNITY IN C. ELEGANSIlka Engelmann and Nathalie PujolAbstractIntroductionRoutes of InfectionPathogen RecognitionSignalling Pathways Involved in the Immune ResponseTranscription Factors Involved in the Immune ResponseEffector Molecules Involved in the Immune ResponseModulation of the Immune Response by the Nervous SystemImmune Response to Pore?Forming ToxinsEpidermal Immune Response to the Fungus Drechmeria ConiosporaConclusion7. IMMUNOCOMPETENT MOLECULES AND THEIR RESPONSE NETWORK IN HORSESHOE CRABSShun?ichiro KawabataAbstractIntroduction and Historical