<p>Chapter 1 Bovine Spongiform Encephalopathy<br>Gianluigi Zanusso, Salvatore Monaco</p><p>Chapter 2 Classical and Atypical Scrapie in Sheep and Goats<br>Christine Fast, Martin H. Groschup</p><p>Chapter 3 Chronic wasting disease and the development of research models<br>Glenn Telling</p><p>Chapter 4 Sporadic Human Prion Disease<br>Pierluigi Gambetti</p><p>Chapter 5 Environmentally-acquired Transmissible Spongiform Encephalopathy<br>Paul Brown</p><p>Chapter 6 Prions in the Environment<br>Shannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. Saunders</p><p>Chapter 7 The Spectrum of Tau Pathology in Human Prion Disease<br>Gabor G. Kovacs, Herbert Budka</p><p>Chapter 8 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion<br>Alexander H. Peden, Mark W. Head, James W. Ironside</p><p>Chapter 9 Species Barriers in Prion Disease<br>Suzette A. Priola</p><p>Chapter 10 Transgenic Mice Modelling<br>Abigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford, Matthew Bishop, Jean C. Manson</p><p>Chapter 11 Prion Transmission Studies in Transgenic Mice<br>Qingzhong Kong<br> <br>Chapter 12 Alternative Models of Prion Diseases<br>Pedro Fernandez-Funez, Edward Málaga-Trillo, Diego E. Rincon-Limas</p><p>Chapter 13 Diagnosis of Prion Disease: Conventional Approaches<br>Inga Zerr, Joanna Gawinecka, Katharina Stoeck, Maren Breithaupt</p><p>Chapter 14 Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion Diseases<br>Jason M. Wilham, Christina D. Orrù, Sarah Vascellari, Andrew G. Hughson, Byron Caughey</p><p>Chapter 15 The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context<br>T. Dean Airey, and Neil R. Cashman</p><p>Chapter 16 Overview on Treatment of Prion Diseases and Decontamination of Prions<br>Richard Knight</p><p>Chapter 17 Immunomodulation<br />Thomas Wisniewski, Fernando Goñi</p>