Macrophages and Natural Killer Cells

Opening Address.- The Impact of Immunology on Medicine.- Major Addresses.- Membrane Receptors and the Regulation of Mononuclear Phagocyte Effector Functions.- Regulation of Macrophage Production.- Symbiotic Relationships between Macrophages and Lymphocytes.- Macrophages and Cancer Metastasis.- Immunological Surveillance versus Immunological Stimulation of Oncogenesis- a Formal Proof of the Stimulation Hypothesis.- Chemotaxis and Phagocytosis.- Physical and Chemical Determinants of Leukocyte Locomotion.- Functionally Distinct Subpopulations of Human Monocytes: Receptors for F-Met-Leu-Phe are Expressed only on the Chemotactically Responsive Cells.- Modulation of Granulocyte Response to the Chemoattractant F-Met-Leu-Phe.- Cytoskeleton-Membrane Interaction and the Remodeling of the Cell Surface during Phagocytosis and Chemotaxis.- Enhancement of Phagocytosis by Neurotensin, a Newly Found Biological Activity of the Neuropeptide.- A Membrane Lectin on Macrophages: Localization and Demonstration of Receptor Recycling.- Cationic Polyelectrolytes and Leukocyte Factors Function as Opsonins, Triggers of Chemilluminescence and Activators of Autolytic Enzymes in Bacteria: Modulation by Anionic Polyelectrolytes in Relation to Inflammation.- Phagocytic Enhancement of Granulocytes and Monocytes by Cationic Proteins from Human Polymorphonuclear Leukocytes.- Inhibition of Complement Dependent Phagocytosis by Normal Human Monocytes following Preincubation with Immune Complexes.- Promonocytes and Monocytes.- Comparison of the In Vivo and In Vitro Proliferation of Monoblasts, Promonocytes, and the Macrophage Cell Line J774.- Properties of the Factor Increasing Monocytopoiesis (FIM) in Rabbit Peripheral Blood.- Monocyte Production and Kinetics in Response to Listeriosis in Resistant and Susceptible Murine Hosts.- MC-1, Identification of an Early Differentiation Marker for Bone Marrow Cells in a Monocytic/ Granulocytic Lineage.- Isolation and Characterization of Human Monocyte Subsets.- Separation and Characterization of Guinea Pig Monocyte Subsets using Counter-Flow Centrifugation Elutriation (CCE).- Changes in Surface Markers of Human Monocytes Following their In Vitro Maturation to Macrophages.- Correlation Between Two New Methods for the Isolation of Human Monocytes: Specific Reversible Agglutination with a Carbohydrate from Pokeweed and by use of the Lectin PA-4.- Characteristics of Human Monocyte Subpopulations with the Use of Flow Cytometer.- Growth Regulation by Macrophages.- Growth Regulation by Macrophages.- Regulation of Bone-Marrow Macrophage Proliferation.- Use of Glucan to Enhance Hemopoietic Recovery after Exposure to Cobalt-60 Irradiation.- The Role of Helper Monocytes in Mitogenic Activation of Human T-Lymphocyte Subpopulations.- Selection of an Immunogenic 3LL Tumor Subline Following Serial Growth In Vivo in the Local Presence of Peritoneal Macrophages.- Mononuclear Phagocytes in the Control of Primary and Secondary Tumor Growth.- Leukocyte Inflammatory Responses.- Synthesis and Release of Lytic Enzymes by Macrophages in Chronic Inflammation.- Weak-Base Induced Lysosomal Secretion by Macrophages: An Alternative Trigger Mechanism that is Independent of Complement Activation.- Inflammatory Response of LPS-Hyporesponsive and LPS-Responsive Mice to Challenge with Gram-Negative Bacteria Salmonella Typhimurium and Klebsiella Pneumoniae.- Characterization of the Leucocytic Infiltrate of Rheumatoid Synovium from Tissue Sections and Synovial Eluates.- Inhibitors of Monocyte Responses to Chemotaxins are Associated with Human Neoplasms.- Depression of Monocyte Inflammatory Response with Pregnancy, Cancer, Regeneration and Surgical Wound Repair.- Pulmonary Alveolar Macrophage Chemotaxis in Malignant Tumors of the Lung.- Serum Blocking Factors in Tumor Bearing Hosts: The Value of Extended Plasma Exchange of In Vitro Immune Parameters of Patients with Advanced Cancer.- The Role of the Inflammatory Response During Tumor Growth.- Defining Macrophage Heterogeneity.- Differentiation Antigens and Macrophage Heterogeneity.- Surface Properties of Activated Macrophages: Sensitized Lymphocytes, Specific Antigen and Lymphokines Reduce Expression of Antigen F4/80 and Fc and Mannose/Fucosyl Receptors, but Induce Ia.- Antigenic Markers on Human Monocytes and Macrophages.- Human Mononuclear Phagocytes Differentiation Antigens.- A Cell Surface Marker Expressed on Cytotoxic Peritoneal Macrophages and Normal Lung Macrophages.- Macrophage Functional Heterogeneity.- Macrophage Hybridomas: An Approach to the Analysis of the Functional Heterogeneity of Macrophages.- Distinction of Macrophage Subpopulations: Measurement of Functional Cell Parameters by Flow Cytometry.- Flow Cytometric Characterization of Macrophages: Fluorescent Substrates as Markers of Activation and Differentiation.- Macrophage Regulation.- Extrinsic Regulation of Macrophage Function by Lymphokines — Effect of Lymphokines on the Stimulated Oxidative Metabolism of Macrophages.- Activation of Tumoricidal and/or Suppressor Macrophages: Different Stimulatory Signals Trigger either Function both In Vivo and In Vitro.- Production of Macrophage Activating Factor by Cytolytic and Noncytolytic T Lymphocyte Clones.- Identification of a T Cell Hybridoma which Produces Extraordinary Quantities of Macrophage Activating Factor.- Autoregulation of Mononuclear Phagocyte function.- Regulation of Macrophage Functions by Interferon.- Influence of Macrophage Activation on the Synthesis of Complement Components C2, C3, C4.- Peritoneal Macrophages Release Prostaglandin E and Thromboxane B2 in Response to C3b.- Prostaglandin E2 is a Feed-Back Regulator of Macrophage Activation.- Antigen Presenting Macrophages.- Mechanisms Controlling Differentiation and Function of Antigen-Presenting Macrophages.- Characteristics of an IA+ Antigen-Presenting Tumor Cell Line.- Antigen Presentation In Vitro by a Murine Macrophage Cell Line.- Ir Gene Regulation of T Cell Proliferation: Requirement for Ia and Antigen Expression on the same Accessory Cell.- Biochemical Evidence for Multiple Ia Molecules.- Ia Determinants on Macrophages: Significance and Role in the Immune Response.- Regulation of Macrophage Ia Expression In Vivo and In Vitro.- Ia and Macrophages in Alloproliferation and Allocytotoxicity.- Role of Macrophages in Human Disease.- Fibronectin: A Mediator of Phagocytosis and its Potential in Treating Septic Shock.- Fibronectin Binds to Charge-Modified Proteins.- RES-Saturation with Accumulation of Hemoglobin-Haptoglobin Complexes in Plasma. A Method for Simultaneous Quantitation of Free Haptoglobin and Hemoglobin-Haptoglobin Complexes.- ?2M-Proteinase Complexes are Taken up by Macrophages during Joint Inflammation.- Splenic Function in Primary Glomerulonephritis.- Immunopathology of Pulmonary Granulomas.- An Investigation about Cell Proliferation in Lymph Node Granulomas Obtained from Sarcoidosis Patients.- Functional Assessment of Alveolar Macrophages in Allergic Asthmatic Patients.- Activation and Effector Mechanisms Against Microbes and Tumors.- Macrophage Activation and Effector Mechanisms against Microbes.- Release of Superoxide and Hydrogen Peroxide from Guinea-Pig Alveolar Macrophages during Phagocytosis of Mycobacterium Bovis BCG.- Stimulation by Various Lectins of Intracellular Killing of Micro-Organisms by Phagocytic Cells.- Glucan Immunomodulation in Experimental E. Coli Sepsis.- Activation of Murine Mononuclear Phagocytes for Destroying Tumor Cells: Analysis of Effector Mechanisms and Development.- Human Monocyte Killing of Tumor Cells: Contribution of an Extracellular Cytotoxin.- The Effect of C. Parvum Therapy on Intratumoral Macrophage Subpopulations.- Tumoricidal and Immunoregulatory Activity of Macrophages from Human Ovarian Carcinomas.- Natural Resistance Mechanisms.- Natural Resistance Mechanisms: Introduction.- Naturally Occurring Cytotoxic Cells.- Regulation of Natural Cytotoxic Activity.- The Role of NK Cells in Resistance of In Vivo Tumors.- Role of Natural Killer Cells and of Interferon in Natural Resistance against Virus Infections.- Overview and Perspectives: Natural Resistance Mechanisms.- Meeting Report.- A Pessimist at the Congress.- The Macrophage and Cancer Pas de Deux.- Contributors.- Author Index.