Cellular Drug Delivery
Principles and Practice
Samenvatting
An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.
Specificaties
Inhoudsopgave
Kinam Park
Part I. Fundamentals of Cell Biology and Cellular Drug Delivery
Cellular Structure, Function, and Membrane Transport
Emily Ware, D. Robert Lu, and Svein Øie
Cellular Growth, Development, and Defensive Response
Yan Huang, Guangliang Pan, Svein Øie, and D. Robert Lu
Part II. Principles of Cellular Drug Delivery
Augmentation of Cell-Mediated Immunity to Virus
Erica L. Woodahl and Rodney J. Y. Ho
Development of Nonviral DNA Delivery Systems
Hans E. J. Hofland, Frank L. Sorgi, and Edward G. Spack
Nucleic Acid Cellular Delivery
Wu Xiao, Chun Zhang, Preeti Yadava, and Jeffrey Hughes
TAT and TAT-Like Peptides for Protein Transduction and Intracellular Drug Delivery
Min Jae Lee, Dexi Liu, Guisheng Zhang, and Xiang Gao
Carrier-Mediated Mechanisms for Cellular Drug Transport
Antara Banerjee, Jeffrey S. Johnston, and Peter W. Swaan
ABC Transporter Proteins and Cellular Drug Resistance: P-Glycoprotein and Analogous Transporters
William W. Johnson
Human Intestinal Cellular Characteristics and Drug Permeability
James E. Polli, Anand Balakrishnan, and Paul R. Seo
Targeted Drug Delivery to Tumor Cells Using Colloidal Carriers
Sushma Kommareddy and Mansoor Amiji
Biological Protein Nanostructures and Targeted Drug Delivery
Guangliang Pan, Svein Øie, and D. Robert Lu
Part III. Practice and Technology of Cellular Drug Delivery
Formulation Considerations for DNA-Based Therapeutics
Thomas J. Anchordoquy, Taylor K. Armstrong, Marion d.C. Molina, S. Dean Allison, Ye Zhang, Mayank M. Patel, Yvonne K. Lentz, and Gary S. Koe
Cationic Microparticles and Emulsions As Effective Delivery Systems for Immune Stimulatory CpG DNA
Derek T. O'Hagan, Manmohan Singh, andJeffrey B. Ulmer
Transdermal Delivery of Antisense Oligonucleotides
WeiQi Lin, Michel Cormier, and Peter E. Daddona
Fc Receptor Targeting With Recombinant Immunoglobulins and Immunoglobulin Formulations
Adrian Bot and Dan Smith
Antibody-Mediated Drug Delivery in Cancer Therapy
Zhenping Zhu and Daniel J. Hicklin
Automated Property Profiling for Cellular Drug Delivery
Edward H. Kerns and Li Di
Index