Nuclear-Cytoplasmic Transport

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Paperback, blz. | Engels
Springer International Publishing | 2019
ISBN13: 9783030084257
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Springer International Publishing e druk, 2019 9783030084257
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Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

Specificaties

ISBN13:9783030084257
Taal:Engels
Bindwijze:paperback
Uitgever:Springer International Publishing

Inhoudsopgave

<div><div>Chapter One-- Assembly of Nuclear Pore Complex</div><div><br></div><div>Dr. Weidong Yang (Pennsylvania, USA) Email: weidong.yang@temple.edu&nbsp;</div><div><br></div><div>Chapter Two – Structure of Yeast Nuclear Pore Complexes</div><div><br></div><div>Dr. &nbsp;Jiong Ma (Shanghai, China), Email: jiongma@fudan.edu.cn</div><div><br></div><div>Chapter Three - Dynamic structures of the nuclear pore complex and their roles in nucleo-cytoplasmic transport</div><div>Dr. Martin Goldberg (Durham, UK), Email: m.w.goldberg@durham.ac.uk</div><div><br></div><div>Chapter Four – Non-canonical roles of nuclear pore proteins&nbsp;</div><div><br></div><div>Dr. &nbsp;Katharine S. Ullman (Utah, USA), Email: katie.ullman@hci.utah.edu</div><div><br></div><div>Chapter Five– On the role of the channel nucleoporins in nuclear transport</div><div>Dr. Sozanne Solmaz (Binghamton, USA), Email: ssolmaz@binghamton.edu</div><div><br></div><div>Chapter Six – Structures of Importins and Exportins</div><div><br></div><div>Dr. &nbsp;Yuh Min Chook (UT Southwestern, USA), Email: yuhmin.chook@utsouthwestern.edu</div><div><br></div><div>Chapter Seven--Navigating the Nuclear Envelope: one or multiple transport mechanisms for integral membrane proteins?</div><div><br></div><div>Dr. &nbsp;Eric C. Schirmer (Edinburg, UK), Email: e.schirmer@ed.ac.uk</div><div><br></div><div><br></div><div>Chapter Eight--mRNA export and its dysregulation in disease&nbsp;</div><div><br></div><div>Katherine Borden (Montreal, Canada), Email: katherine.borden@umontreal.ca</div><div><br></div><div>Chapter Nine--Coarse-grained molecular dynamics of the natively-unfolded domain of the NPC</div><div><br></div><div>Dr. &nbsp;P. R. Onck (Groningen, The Netherlands), Email: &nbsp;p.r.onck@rug.nl</div><div><br></div><div><br></div><div>Chapter Ten---On the effects of leukemogenic nucleoporin fusion proteins on nucleocytoplasmic transport and gene expression</div><div><br></div><div>Dr. &nbsp; Birthe Fahrenkrog (Brussels, Belgium), Email: bfahrenk@ulb.ac.be</div><div><br></div><div><br></div><div>Chapter Eleven---Structure and Function of the Nuclear Pore Complex Revealed by Advanced Fluorescence Microscopy</div><div><br></div><div>Dr. &nbsp;Weidong Yang (Pennsylvania, USA) Email: weidong.yang@temple.edu&nbsp;</div></div>
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        Nuclear-Cytoplasmic Transport