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Vascular Ion Channels in Physiology and Disease

Specificaties
Paperback, blz. | Engels
Springer International Publishing | 2018
ISBN13: 9783319806136
Rubricering
Springer International Publishing e druk, 2018 9783319806136
€ 204,99
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Samenvatting

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.
 Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Specificaties

ISBN13:9783319806136
Taal:Engels
Bindwijze:paperback
Uitgever:Springer International Publishing

Inhoudsopgave

<div>Foreword</div><div>Mark T. Nelson</div><div><br></div><div>I. Ion channel regulation of vascular tone and blood flow. &nbsp;Changes with hypertension.</div><div><br></div><div>I.1. Endothelial cells</div><div><br></div><div>I.1.1. Endothelial cell ion channel expression and function in arterioles and resistance arteries</div>William F. Jackson<div><br></div><div>I.1.2. Contribution and Regulation of Calcium channels in Endothelial Cells</div><div>Kwong Tai Cheng, Avia Rosenhouse-Dantsker, and Asrar B. Malik &nbsp;&nbsp;</div><div><br></div><div>I.1.3. Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular tone</div><div>David W. Busija, Ibolya Rutkai, and Prasad V. Katakam</div><div><br></div><div>I.1.4. Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteries</div><div>Erik J. Behringer and Steven S. Segal</div><div><br></div><div>I.1.5. Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatments</div><div>Ralf Köhler. Aida Olivan-Viguera</div><div><br></div><div>I.2. Smooth Muscle Cell</div><br><div>I.2.1. Regional Variation in Arterial Myogenic Responsiveness - Links To Potassium Channel Diversity/Function</div><div>Michael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong and Andrew P. Braun</div><div><br></div><div>I.2.2. Ion Channel Trafficking and Control of Arterial Contractility</div><div>M. Dennis Leo and Jonathan H. Jaggar</div><div><br></div>I.2.3. Abnormalities of Vascular Ion Channels during Hypertension<anup k.="" srivastava,="" lee="" ann="" macmillan-crow,="" sung="" w.="" rhee,="" nancy="" j.="" rusch<br><div>I.2.4. Kv7 Potassium Channels as Therapeutic Targets in Cerebral Vasospasm</div><div>Bharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, and Kenneth L. Byron</div><div><br></div><div>I.2.5. Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases&nbsp;</div>Fan Zhang, Pin-Lan Li<div><br></div><div>II. Ion channels in the regulation of cell proliferation, remodeling, hypertrophy and angiogenesis</div><div><br></div><div>II.1. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle</div><div>John G. McCarron, Susan Chalmers, Calum Wilson &amp; Mairi E. Sandison</div><div><br></div><div>II.2. Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors&nbsp;</div>Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, and Charles K. Thodeti<div><br></div><div>II.3. TRPC and Orai channels in store-operated calcium entry and vascular remodeling</div><div><br></div><div>David J Beech, Jing Li, Lynn McKeown, and Hollie L Appleby</div><div><br></div>II.4. Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodeling<div>Ramon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, and Jason X.-J. Yuan</div><div><br></div><div>III. Ion channel regulation by lipids and channel modifications in metabolic disease</div><div><br></div><div>III.1. Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites&nbsp;</div><div>Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-Dantsker</div><br><div>III.2.&nbsp;Membrane lipids and modulation of vascular smooth muscle ion channels</div><div>Alex M. Dopico, Anna N. Bukiya and Guruprasad Kuntamallappanavar</div><div><br></div><div>III.3. Transient receptor potential channels in metabolic syndrome-induced coronary artery disease</div><div>Stacey L. Dineen, Zachary P. Neeb, Alexander G. Obukhov, and Michael Sturek</div><div><br></div>III.4. Mitochondrial ion channels in metabolic disease<div>Aaron H Truong, Saravanakumar Murugesan, Katia D Youssef, and Ayako Makino</div><div><br></div><div>Index</div>
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        Vascular Ion Channels in Physiology and Disease