Interferons: Mechanisms of Action and Role in Cancer Therapy

A great deal of new information has been obtained during the
past four years, and this monograph provides a clear and
well reviewed update on biochemical mechanisms and the
results of important new clinical studies using the
interferons.
Reviews include what is presently known about the
biosynthesis, physiological role and mechanisms of action of
the interferons (alpha, beta, gamma). New biochemical
information on interferon-receptor interactions and
signalling pathways is provided. The pharmacokinetic
considerations in treating leukemia, lymphoma, myeloma,
neuroendocrine tumors and other solid tumors are reviewed
with special emphasis on studies of adjuvant chemotherapy in
malignancies of the immune system.