The Pathologic Physiology of Dementia

1. Historical Overview of Dementia.- Prelude to the Modern Era.- Age of Alzheimer and Kraepelin.- History of Alzheimer’s Disease.- References.- 2. Clinical Manifestations as a Determinant of Dementia.- General Considerations.- Functional Mental Syndromes as a Manifestation of Brain Disease.- Acute Confusion.- Specialized Syndromes in Dementia.- Summary of Specialized Syndromes.- Summary of Clinical Manifestations.- References.- 3. Diagnostic Tests of Dementia as Research Tools.- Psychological Tests of Intelligence.- Electroencephalography.- Radiographic Technique.- Morphologic and Chemical Assay of Brain Tissue.- References.- 4. Treatment of Senile Dementia.- Acute Confusion.- Circulatory Agents.- Metabolic Stimulants.- Psychoactive Drug Therapy.- Antiviral Therapy.- Surgical Management.- Conclusions.- References.- 5. Epidemiology of Dementia.- General Considerations.- Previous Surveys of Senile Dementia.- The GM Survey.- Etiologic Implications of Epidemiology.- Concluding Remarks.- References.- 6. Current Evaluation of Pathologic Correlates of Dementia.- Congophilic Angiopathy.- Senile Plaques.- Neurofibrillary Tangles.- Creutzfeldt-Jakob Disease.- Other Pathologic Correlates.- References.- 7. Arteriosclerotic Dementia.- Dementia Following Multiple Strokes.- Little Strokes.- Diffuse Cerebral Ischemia.- Cerebral Blood Flow Study of Dementia.- Summary.- References.- 8. Critical Evaluation of the Concept of Mental Aging.- Functional Aspects of the Elderly Brain.- Pathology of the Aged Brain.- Epidemiology of Mental Aging.- Conclusions.- Summary of Mental Aging.- References.- 9. Nature and Cause of Alzheimer’s Disease: The Case for Slow Virus Infection.- Nature of AD.- Etiologic Potential for AD.- References.