Antonino Cattaneo,
Silvia Biocca
Springer Berlin Heidelberg
0e druk, 2012
9783662079942
Intracellular Antibodies
Development and Applications
Specificaties
Paperback, 196 blz.
|
Engels
Springer Berlin Heidelberg |
2012
ISBN13: 9783662079942
Rubricering
Onderdeel van serie
Biotechnology Intelligence Unit
Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
Recent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells. This volume describes how the ectopic expression of antibodies, as secreted or as intracellularly retargeted molecules, can be exploited to block biological functions or to confer new phenotypic traits (e.g. resistance to a virus). This is the first book describing this emerging technology, which is receiving increasing attention for application in many different fields and biological systems - from human gene therapy to plant biotechnology.
Specificaties
ISBN13:9783662079942
Taal:Engels
Bindwijze:paperback
Aantal pagina's:196
Uitgever:Springer Berlin Heidelberg
Druk:0
Inhoudsopgave
1. Intracellular and Intercellular Immunization.- 2. Current Methods for Genotypic and Phenotypic Knock-Outs in Mammalian Cells.- 3. Recombinant Antibodies for Ectopic Expression.- 4. Assembly and Folding of Antibodies in Natural and Artificial Environments.- 5. Protein Sequence Motifs Involved in Intracellular Trafficking.- 6. Intercellular Immunization.- 7. Intracellular Immunization.- 8. Gene Therapy and Research Applications of Intrabodies for Human Infectious Diseases.- 9. Plantibodies: Immunomodulation and Immunotherapeutic Potential.- 10. From Phage Libraries to Intracellular Immunization.- 11. Perspectives and Conclusions.