Klaus Ley
Birkhäuser Basel
2007e druk, 2007
9783764379742
Adhesion Molecules: Function and Inhibition
Specificaties
Gebonden, 309 blz.
|
Engels
Birkhäuser Basel |
2007e druk, 2007
ISBN13: 9783764379742
Rubricering
Onderdeel van serie
Progress in Inflammation Research
Verwachte levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Specificaties
ISBN13:9783764379742
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:309
Uitgever:Birkhäuser Basel
Druk:2007
Inhoudsopgave
Capture and rolling.- P-selectin glycoprotein ligand-1 (PSGL-1).- L-selectin-mediated leukocyte adhesion and migration.- P- and E-selectin.- Firm adhesion.- Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment.- ?4-integrins: structure, function and secrets.- VCAM-1 and its functions in development and inflammatory diseases.- Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function.- Transendothelial migration.- PECAM: Regulating the start of diapedesis.- Role of ?6?1 integrin in leukocyte adhesion and transmigration.- Vascular adhesion protein-1 (VAP-1).- The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues.- Structure and function of JAM proteins.- Promises and limitations of targeting adhesion molecules for therapy.