Trends in Gastroenterology and Hepatology

1 Gastroenterology and the New Millennium.- Reflecting Forward: Gastroenterology in the New Millennium.- 2 Ulcerative Colitis Pathophysiology and Therapy.- Pathophysiology of and New Treatment for Ulcerative Colitis.- 3 Life Style-Related Diseases and Gastroenterology.- New Target of Gastroenterology: Overcoming Life Style-Related Diseases.- 4 Apoptosis in Digestive Organs.- Examination of Cytotoxic T Lymphocyte-Mediated Apoptosis Pathway in Peptic Ulcer Formation with or without H. pylori Infection.- Epidermal Growth Factor Inhibits Helicobacter pylori Lipopolysaccharide-Induced Apoptosis of Primary Cultures of Gastric Pit Cells.- Impaired Sensitivity to Fas-Induced Apoptosis of Lymphocytes in Ulcerative Colitis Lesions.- Tumor Necrosis Factor ?-Induced Hepatic Apoptosis and Hepatocyte Sensitization.- Molecular Mechanisms of D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice and the Effects of Therapeutic Agents.- Ethanol-Induced Apoptosis Mediated by Mitochondrial Permeability Transition in Primary Cultured Sinusoidal Endothelial Cells.- Therapeutic Strategies for Hepatocellular Carcinoma Based on Analyses for Resistance to Apoptosis Mediated by Activation of Intracellular Signal Pathways.- Expression of Apoptosis-Related Factors in Human Pancreatic Duct Cell Carcinoma and Intraductal Papillary-Mucinous Tumor.- 5 Is Nitric Oxide Friend or Foe?.- Effect of Exogenous and Endogenous Nitric Oxide on Endothelial Permeability Induced by Oxidants In Vitro.- Gastric Carcinoma and Helicobacter pylori Infection: Role of Nitric Oxide and Inflammatory Cytokines in Gastric Carcinogenesis.- Does Cyclooxygenase-2 Down-Regulate Gastric Inflammation?.- Regulation of Mucin Synthesis by Neuronal Nitric Oxide Synthase in Gastric Pit Cells.- Role of Nitric Oxide and Capsaicin-Sensitive Sensory Nerves in Gastric Receptive Relaxation and Adaptive Relaxation in Isolated Stomachs of Guinea Pigs.- Role of Inducible Nitric Oxide Synthase in Murine Colitis.- Role of Nitric Oxide in the Progression of Severe Acute Pancreatitis.- Role of Nitric Oxide in the Progression of Acute Pancreatitis.- Protective Effect of Nitric Oxide on Acute Liver Failure in Rats.- Regulatory Mechanism of Cationic Amino Acid Transporters in Hepatic Sinusoidal Ito Cells.- 6 Transcription Factors in Digestive Organs.- Novel NADPH Oxidase, Moxl, Expressed in Cultured Gastric Pit Cells: Modulation of NF-?B Activation.- Role of PPAR? in the Growth and Differentiation of Gastric and Colorectal Cancers.- PPAR? Ligand and Induction of Growth Arrest in Pancreatic Cancer Cells.- Role of ?-Catenin During Early Colorectal and Hepatic Carcinogenesis.- Growth Inhibition of Hepatoma Cells by Type 1 Interferons: Modification by Mutations in the Interferon Regulatory Factor-1 Gene.- Growth Inhibition of Pancreatic Cancer Cell Lines by Ligand Activation of Nuclear Hormone Receptors Through Up-Expression of WAFl/CIPl/p21.- 7 The Role of Antigen-Presenting Cells in Pathophysiology.- Immunopathological Features of Granuloma Formation in the Intestinal Mucosa of Patients with Crohn’s Disease.- Helicobacter pylori and N-Methyl-N’-nitro-N-nitrosoguanidine Induction of Dendritic Cell Infiltration of the Pyloric Mucosa of Mongolian Gerbils.- Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells.- Autoimmune Mechanisms of Cancer-Associated Paraneoplastic Syndromes: A Review.- Antitumor Activity Against Gastrointestinal and Hepatocellular Carcinoma Induced by Immunization with Fusion of Dendritic and Carcinoma Cells in Mice.- 8 The Pathophysiology of Inflammatory Bowel Disease.- Essential Role for Interleukin-6 in the Pathogenesis of Crohn’s Disease.- Activation of Nuclear Factor ?B in Dextran Sulfate Sodium-Induced Colitis in Mice and Their Inhibition by Phenyl N-tert-Butylnitrone.- Essential Roles for Th2-Type Responses in Chronic Intestinal Inflammation.- Induction of Colitis and Exocrinopathy in Nude Mice Induced by Immunocompetent Cell Transfer from Murine Retrovirus-Infected Mice.- Potential Role of Mucosal Addressin Cell Adhesion Molecule-1 in Inflammatory Bowel Diseases.- Anti-Saccharmomyces cerevisiae Antibody in Inflammatory Bowel Disease.- Reactive Oxygen Species and Colonic Epithelial Cell Apoptosis in Ulcerative Colitis.- 9 NSAID-lnduced Gastric Lesions.- Effect of Antiulcer Drugs for Treatment of Nonsteroidal Antiinflammatory Drug-Induced Ulcers.- Role of Intravascular Neutrophils in the Pathogenesis of Aspirin-Induced Gastric Mucosal Injury.- Mucin Secretion Evoked by Prostaglandin E2 in Guinea Pig Antral Mucous Cells: Role of EP1/EP4 Receptors.- Effects of Indomethacin and NS-398 on Acid-Induced E-Cadherin Surface Expression in Rat Gastric Epithelial Cells.- Roles of Reactive Nitrogen Species in Helicobacter-Related Carcinogenesis.- Interaction Between Helicobacter pylori Infection and NSAID Use.- Interrelations of Nonsteroidal Antiinflammatory Drugs, H. pylori Infection, and Gastric Damage.- 10 Prevention of Disease by Modulation of Microcirculation.- Microvascular Leukocyte Activation and Apoptosis in Helicobacter pylori-Colonized Gastric Mucosa.- Alteration of Gastric Microcirculatory Architecture During Healing of Acetic Acid-Induced Ulcer and Helicobacter pylori Infection.- Cyclooxygenase and Colon Cancer.- Contribution of Colon Cancer Cells to Mesenchymal Cells in the Formation of Hepatic Metastasis.- Hepatic Microcirculation in Massive Liver Necrosis and Liver Regeneration.- Prevention of Hepatic Ischemia/Reperfusion Injury by Microcirculatory Regulation: Application to Liver Transplantation.- Genetic Manipulation of Sinusoidal Endothelial Cells.- Controlling Tumor Microenvironment by the Antiangiogenesis Strategy.- Pancreatic Blood Flow in Chronic Alcoholic Pancreatitis.- 11 Hepatic Regeneration Update.- The Role of Hepatic Oval Cells in Hepatic Regeneration: Possible Clinical Applications.- Hepatoma-Derived Growth Factor: Involvement in Liver Development and Regeneration.- Tumor Necrosis Factor and Liver Regeneration.- Heparin-Binding EGF-Like Growth Factor: Hepatotrophic Factor in Liver Regeneration.- Effects of Growth Stimulatory and Inhibitory Factors on Signal Transduction of Cultured Rat Hepatocyte and the Regulation of Cyclin D1 Transcription.- Significance of the Relation Between Hepatocyte Growth Factor and Transforming Growth Factor-? in Hepatocyte Proliferation.- 12 Hepatic Fibrosis Research and Its Application to Therapy.- Transcriptional Regulation of Type I Collagen Gene Expression by Transforming Growth Factor-? and Smad Proteins.- Clinical Usefulness of Plasma MMP-9 Assay Compared with the Plasma MMP-2 Assay in Patients with Chronic Liver Disease.- Molecular Mechanisms of Matrix Metalloproteinase-1 Gene Expression in Hepatic Stellate Cells.- Molecular Analysis of Stellate Cells Activation by Proteomics.- Tissue Inhibitor of Metalloproteinase-1: Strong Promotion of Liver Fibrosis Development in the Transgenic Mouse Model.- Antioxidant and Antiapoptotic Activities of a Tissue-Specific Selective Estrogen Receptor Modulator, Idoxifene, in Rat Fibrotic Liver and Cultured Rat Hepatocytes.- Blockade of TGF? Signaling: Prevention of Fibrosis/Dysfunction and Enhancement of Hepatocyte Regeneration in Injured Liver.- Protease Inhibitors: Suppression of Activation of Hepatic Stellate Cells by Inhibiting TGF? Generation.- Plasma Transforming Growth Factor-?1: A Useful Marker for Hepatic Fibrosis in Chronic Hepatitis C.- Key Word Index.