Multiple Drug Resistance in Cancer

P-glycoprotein structure and evolutionary homologies.- Molecular analysis of the multidrug transporter.- Molecular cytogenetics of multiple drug resistance.- Antibodies in the study of multiple drug resistance.- Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug.- Topoisomerase I in multiple drug resistance.- Topoisomerase II in multiple drug resistance.- Glutathione-related enzymes, glutathione and multidrug resistance.- Pharmacologic circumvention of multidrug resistance.- Multidrug resistance (MDR) genes in haematological malignancies.- Human cell lines as models for multidrug resistance in solid tumours.- Studies on low-level MDR cells.- Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro.- The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells.- Mathematical models for multidrug resistance and its reversal.- The biology of radioresistance: similarities, differences and interactions with drug resistance.- Kinetic resistance to anticancer agents.- Cytochromes P450 and drug resistance.- Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors.- Clinical significance of cellular resistance in tumours to cytotoxic chemotherapy and radiotherapy.- Key word index.