Leonid Sazanov
Springer Netherlands
2012e druk, 2014
9789401783347
A Structural Perspective on Respiratory Complex I
Structure and Function of NADH:ubiquinone oxidoreductase
Specificaties
Paperback, 286 blz.
|
Engels
Springer Netherlands |
2012e druk, 2014
ISBN13: 9789401783347
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.
Specificaties
ISBN13:9789401783347
Taal:Engels
Bindwijze:paperback
Aantal pagina's:286
Uitgever:Springer Netherlands
Druk:2012
Inhoudsopgave
<p>Foreword; Leonid Sazanov</p><p>Part I: Structure and mechanism of complex I<br>1. Structure of complex I; Rouslan Efremov and Leonid Sazanov<br>2. On the mechanism of the respiratory complex I; Thorsten Friedrich, Petra Hellwig, and Oliver Einsle<br>3. Iron–sulfur clusters in complex I; Eiko Nakamaru-Ogiso <br>4. Current Topics of the Inhibitors of Mitochondrial Complex I; Hideto Miyoshi <br>5. My Fifty Years Association with Complex I Study; Tomoko Ohnishi</p><p>Part II: Evolution of complex I<br>6. The Evolutionary Relationship between Complex I and [NiFe]-hydrogenase; Anne Volbeda and Juan C. Fontecilla-Camps<br>7. Recruitment of the antiporter module - a key event in complex I evolution; Vamsi Krishna Moparthi and Cecilia Hägerhäll</p><p>Part III: Mutations in complex I subunits and medical implications<br>8. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach; Takao Yagi, Jesus Torres-Bacete, Prem Kumar Sinha, Norma Castro-Guerrero, and Akemi Matsuno-Yagi <br>9. Cellular consequences of mtDNA-encoded mutations in NADH:ubiquinone oxidoreductase; Mina Pellegrini, Jan A.M. Smeitink, Peter H.G.M. Willems and Werner J.H. Koopman</p><p>Part IV: Subunit composition and assembly of mitochondrial complex I<br>10. The assembly of human complex I; Jessica Nouws, Maria Antonietta Calvaruso, Leo Nijtmans<br>11. Complexes I in the green lineage; Claire Remacle, Patrice Hamel, Véronique Larosa, Nitya Subrahmanian, Pierre Cardol</p><p>Part V: Supercomplexes in mitochondria<br>12. Supramolecular organization of the respiratory chain; Janet Vonck </p><p>Index</p>