Drosophila Models for Human Diseases
Samenvatting
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases.
The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Specificaties
Inhoudsopgave
<p>Masamitsu Yamaguchi, Hideki Yoshida, Department of Applied Biology, Kyoto Institute of Technology</p>
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Ch2 Adult intestine aging model<p></p>
<p>Takashi Okumura, Koji Takeda, Takashi Adachi-Yamada, Gakushuin University</p>
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<p>Ch3 Alzheimer’s disease model</p>
<p>Leo Tsuda, National Center for Geriatrics and Gerontology (NCGG)</p>
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<p>Ch 4 Parkinson’s disease model</p>
Dang Thi Phuong Thao, University of Science, Vietnam National University, Ho Chi Minh City<p></p>
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<p>Chapter 5</p>
<p>Repeat expansion disease model</p>
<p>Morio Ueyama, Yoshitaka Nagai, Osaka University</p>
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<p>Ch6 Amyotrophic lateral sclerosis model</p>
Yumiko Azuma, Takahiko Tokuda, Kyoto Prefectural University of Medicine<p></p>
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<p>Ch7 Charcot-Marie-Tooth disease model</p>
<p>Masamitsu Yamaguchi, Hiroshi Takashima, Kyoto Institute of Technology, Kagoshima University</p>
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<p>Ch8 Role of long non-coding RNA in neurological diseases</p>
<p>Luca Lo Piccolo, Kyoto Institute of Technology</p>
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<p>Ch9 Muscular dystrophy model</p>
<p>Saranyapin Potikanond, Wutigri Nimlamool, Jasprien Noordermeer, Lee Fradkin</p>
<p>Chiang Mai University, Molecular biology department, Leiden University Medical Center (LUMC), Department of Neurobiology, UMass Medical School</p>
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<p>Ch10 Cancer model</p>
<p>Tatsushi Igaki, Kyoto University</p>
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<p>Ch11 Leukemia model</p>
<p>Lucas Waltzer, Centre de Biologie du Développement, CNRS – Université Paul Sabatier, Toulouse, France</p>
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<p>Ch12 Diseases of replication /repair genes</p>
<p>Sue Cotterill, St Georges University of London</p>
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Ch13 Drosophila models for studying UPR in insulin-like peptide producing cells and onset of type I diabetes<p></p>
<p>Yoshihiro H. Inoue, Insect Biomedical Research Center, Kyoto Institute of Technology</p>
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Ch14 Metabolomics study on Drosophila models<p></p>
<p>Phan Nguyen Thuy An, Eiichiro Fukusaki, Graduate School of Engineering, Osaka University</p>
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<p>Ch15 Humanized flies for functional analysis of the human genome and cross-species comparison</p>
<p>Toshiyuki Takano-Shimizu, Department of Drosophila Genomics and Genetic Resources, Kyoto Institute of Technology</p>
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<p>Ch16 Designs for Flies</p>
<p>Frank Kolkman, Julia Cassim, Royal College of Arts, Kyoto Institute of Technology</p>
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