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Pharmacogenomics An Introduction and Clinical Perspective

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Paperback, blz. | Engels
McGraw-Hill Education | 2012
ISBN13: 9780071741699
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McGraw-Hill Education e druk, 2012 9780071741699
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A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS

A Doody's Core Title for 2017!

The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus anexamination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviewsbasic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties.

FEATURESImportant overview of general pharmacogenomics and pharmacogenetics concepts, including geneticvariation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomicsDiscussion of regulatory considerations in pharmacogenomicsFocus on the role of health care professionals along with a review of related privacy issues,as well as broader ethical, legal, and social considerationsIn-depth chapters on drug metabolism and transportersPractical, step-by-step guidance on public access to pharmacogenomic testing and patient counselingUp-to-date coverage of non-genetic influences on pharmacogenomicsEmphasis on gene-drug interactionsNumerous tables and figuresChapter-ending referencesConcise learning objectives at the beginning of each chapterCase studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Specificaties

ISBN13:9780071741699
Taal:Engels
Bindwijze:paperback

Inhoudsopgave

<p>Section I. General Concepts<br>1. Developing Perspectives on Pharmacogenomics<br>2. Genetic Concepts of Pharmacogenomics: Basic Review of DNA, Genes, Polymorphisms, Haplotypes and Nomenclature<br>3. Analytical Methods to Identify Genetic Variations and Bioinformatics<br>4. Regulatory Considerations in Pharmacogenomics at EMA and US FDA<br>5. Ethical, Legal, and Social Issues Associated with Pharmacogenomics<br>6A. Pharmacogenetics of Cytochrome P450<br>6B. Phase II Drug-Metabolizing Enzymes<br>7. Drug Transporters<br>8. Nongenetic Influences on Drug Metabolism<br>9. Public Access to Pharmacogenomic Testing and Patient Counseling<br>10. Understanding the Use of Pharmacoeconomic Analysis to Assess the Economic Impact of Pharmacogenomic Testing</p><p>Section II. Clinical Application of Pharmacogenomics<br>11. Cardiovascular Pharmacogenomics<br>12. Pharmacogenomics and Pharmacogenetics for Infectious Diseases<br>13. Pharmacogenomics in Oncology<br>14. Psychiatry and Addiction Medicine<br>15. Immunology,Transplantation,and Vaccines<br>16. Pharmacogenomics in Neurology<br>17A. Pharmacogenomics of Gastrointestinal Drugs: Focus on Proton Pump Inhibitors<br>17B. Genomics and the Kidney</p><p>Index</p>
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        Pharmacogenomics An Introduction and Clinical Perspective