<br>Contributors</br><br>Foreword</br><br>Rise of the Machines – On the Threshold of a New Era in Epilepsy Research</br><br>Introduction: Applications and Emerging Concepts of Computational</br><br>Neuroscience in Epilepsy Research</br><br>Part I Computational Modeling Techniques and Databases in Epilepsy Research</br><br> 1 Simulation of Large Networks: Technique and Progress</br><br> 2 The Neuron Simulation Environment in Epilepsy Research</br><br> 3 The CoCoDat Database: Systematically Organizing and Selecting Quantitative Data on Single Neurons and Microcircuitry</br><br> 4 Validating Models of Epilepsy</br><br> 5 Using NeuroConstruct to Develop and Modify Biologically Detailed 3D Neuronal Network Models in Health and Disease</br><br> 6 Computational Neuroanatomy of the Rat Hippocampus: Implications and Applications to Epilepsy</br><br>Part II Epilepsy and Altered Network Topology</br><br> 7 Modeling Circuit Alterations in Epilepsy: A Focus on Mossy Cell Loss and Mossy Fiber Sprouting in the Dentate Gyrus</br><br> 8 Functional Consequences of Transformed Network Topology in Hippocampal Sclerosis</br><br> 9 Multiple-Scale Hierarchical Connectivity of Cortical Networks Limits the Spread of Activity</br><br>Part III Destabilization of Neuronal Networks</br><br> 10 Computer Simulations of Sodium Channel Mutations that Cause Generalized Epilepsy with Febrile Seizures Plus</br><br> 11 Gain Modulation and Stability in Neural Networks</br><br> 12 Neocortical Epileptiform Activity in Neuronal Models with Biophysically Realistic Ion Channels</br><br> 13 Corticothalamic Feedback: A Key to Explain Absence Seizures</br><br> 14 Mechanisms of Graded Persistent Activity: Implications for Epilepsy</br><br> 15 Small Networks, Large Networks, Experiment and Theory – Can We Bring Them Together with Oscillations, Heterogeneity and Inhibition?</br><br>Part IV Homeostasis and Epilepsy</br><br> 16 Stability and Plasticity in Neuronal and Network Dynamics</br><br> 17 Homeostatic Plasticity and Post-Traumatic Epileptogenesis</br><br>Part V Mechanisms of Synchronization</br><br> 18 Synchronization in Hybrid Neuronal Networks</br><br> 19 Complex Synaptic Dynamics of GABAergic Networks of the Hippocampus</br><br> 20 Experimental and Theoretical Analyses of Synchrony in Feedforward Networks</br><br> 21 Modulation of Synchrony by Interneurons: Insights from Attentional Modulation of Responses in the Visual Cortex</br><br>Part VI Interictal to Ictal Transitions</br><br> 22 Cellular and Network Mechanisms of Oscillations Preceding and Perhaps Initiating Epileptic Discharges</br><br> 23 Transition to Ictal Activity in Temporal Lobe Epilepsy: Insights from Macroscopic Models</br><br> 24 Unified Modeling and Analysis of Primary Generalized Seizures</br><br> 25 A Neuronal Network Model of Corticothalamic Oscillations: The Emergence of Epileptiform Absence Seizures</br><br> 26 Extracellular Potassium Dynamics and Epileptogenesis</br><br> 27 Slow Waves Associated with Seizure Activity</br><br>Part VII Seizure Dynamics</br><br> 28 Dynamics of Epileptic Seizures during Evolution and Propagation</br><br> 29 Are Correlation Dimension and Lyapunov Exponents Useful Tools for Prediction of Epileptic Seizures?</br><br> 30 Towards a Dynamics of Seizure Mechanics</br><br>Part VIII Towards Computer-Aided Therapy</br><br> 31 Principles and Practice of Computer-Aided Drug Design as Applied to the Discovery of Antiepileptic Agents</br><br> 32 Computation Applied to Clinical Epilepsy and Antiepileptic Devices</br><br> 33 Microelectrode-based Epilepsy Therapy: A Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomimetic Maintenance of Normal Hippocampal Function</br><br>Index</br><br></br>
