Preface: Hyaluronan and Cancer<br>Robert Stern <br><br>Section I: Historical Overview<br><br>1.Association between “acid mucopolysaccharides and malignancy: an old <br>concept comes of age, finally <br>Robert Stern <br><br>Section II: Cell Biology of Hyaluronan in Cancer <br><br>2.Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells<br>Mark G. Slomiany and Bryan P. Toole <br><br>3.Growth factor regulation of hyaluronan deposition in malignancies<br>Paraskevi Heldin, Eugenia Karousou, and Spyros S. Skandalis<br><br>4.HYALURONAN BINDING PROTEIN 1 (HABP1) IN CANCER BIOLOGY<br>Kasturi Datta <br><br>Section III: Hyaluronan Receptors and Signal Transduction Pathways<br><br>5.CD44 meets merlin and ezrin: Their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of merlin<br>Ivan Stamenkovic and Qin Yu<br><br><br>6.Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation and tumor progression <br>Lilly Y.W. Bourguignon<br><br>7.Adhesion and penetration: two sides of CD44 signal transduction cascades in the context of cancer cell metastasis<br>David J.J. Waugh, Ashleigh McClatchey, Nicola Montgomery, and Suzanne McFarlane<br><br>8.INVOLVEMENT OF CD44, A MOLECULE WITH A THOUSAND FACES, IN CANCER DISSEMINATION<br>David Naor, Shulamit B. Wallach-Dayan, Muayad A. Zahalka, and Ronit Vogt Sionov<br><br>9.Rhamm/Hmmr: an intinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation. <br>James B. McCarthy and Eva A. Turley<br><br><br>Section IV: Hyaluronan Synthesis<br><br>10.Altered hyaluronan biosynthesis in cancer progression<br>Naoki Itano and Koji Kimata <br><br>Section V: Hyaluronan Degradation, the Hyaluronidases, and the Products of Degradation<br><br>11.HYALURONDIASE: BOTH A TUMOR PROMOTER AND SUPPRESSOR<br>Vinata B. Lokeshwar and Marie G. Selzer<br><br>12.The hyaluronidases in cancer biology<br>Robert Stern<br><br>13.Hyaluronan fragments: informational polymers commandeered by cancers<br>Kazuki N. Sugahara<br><br>Section VI : Hyaluronan in Cancer Epithelial-Stromal Interactions<br><br>14.Hyaluronan in human tumors: importance of stromal and cancer cell-associated hyaluronan<br>Raija H. Tammi , Anne H. Kultti, Veli-Matti Kosma, Risto Pirinen, Päivi Auvinen, and Markku I. Tammi<br><br>15.THE ONCOFETAL PARADIGM REVISITED: MSF AND HA AS CONTEXTUAL DRIVERS OF CANCER PROGRESSION<br>Seth L. Schor, Ana M. Schor, Ian R. Ellis, Sarah J. Jones, Margaret Florence, Jacqueline Cox, and Anne-Marie Woolston <br><br>Section VII: Hyaluronan and Individual Cancers<br><br>16.Hyaluronan synthesis and turnover in prostate cancer <br>Melanie A. Simpson <br><br>17.Role of hyaluronan in melanoma progression<br>Carl Gebhardt, Marco Averbeck, Ulf Anderegg, and Jan C. Simon <br><br>18.Role of Hyaluronan metabolism in the initiation, invasion and metastasis of Breast cancer<br>Tracey J. Brown and Natalie Thomas<br><br>Section VIII: Clinical Uses of Hyaluronan-Related Biomaterials as Anti-Cancer Agents <br><br>19. Clinical application of hyaluronidase in combination cancer chemotherapy: a historic perspective<br>Gerhard Baumgartner and Gerhard Hamilton<br><br>20.Exploring the hyaluronan-CD44 interaction for cancer therapy<br>Virginia M. Platt and Francis C. Szoka <br><br>Section IX: A New Perspective<br><br>21.Hyaluronidase-2 and its role as a cell-entry receptor for sheep<br>retroviruses that cause contagious respiratory tract cancers<br>A. Dusty Miller
