Saverio Bettuzzi,
Sabina Pucci
Elsevier Science
e druk, 2009
9780123747723
Clusterin
Specificaties
Gebonden, blz.
|
Engels
Elsevier Science |
2009
ISBN13: 9780123747723
Rubricering
Onderdeel van serie
Advances in Cancer Research
Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Specificaties
Inhoudsopgave
<p>. Introduction</p> <p>Saverio Bettuzzi</p> <p>2. Clusterin (CLU): From One Gene and Two</p> <p>Transcripts to Many Proteins</p> <p>Federica Rizzi, Mariangela Coletta, and Saverio Bettuzzi</p> <p>3. The Shifting Balance Between CLU Forms</p> <p>During Tumor Progression</p> <p>Sabina Pucci and Saverio Bettuzzi</p> <p>4. Regulation of Clusterin Activity by Calcium</p> <p>Beata Pajak and Arkadiusz Orzechowski</p> <p>5. Nuclear CLU (nCLU) and the Fate of the Cell</p> <p>Saverio Bettuzzi and Federica Rizzi</p> <p>6. The Chaperone Action of Clusterin and Its Putative Role</p> <p>in Quality Control of Extracellular Protein Folding</p> <p>Amy Wyatt, Justin Yerbury, Stephen Poon,</p> <p>Rebecca Dabbs, and Mark Wilson</p> <p>7. Cell Protective Functions of Secretory</p> <p>Clusterin (sCLU)</p> <p>Gerd Klocks, Markus Baiersdo¨ rfer, and Claudia Koch-Brandt</p> <p>8. Clusterin: A Multifacet Protein at the Crossroad of</p> <p>Inflammation and Autoimmunity</p> <p>Ge´ raldine Falgarone and Gilles Chiocchia</p> <p>9. Oxidative Stress in Malignant Progression: The Role of Clusterin,</p> <p>A Sensitive Cellular Biosensor of Free Radicals</p> <p>Ioannis P. Trougakos and Efstathios S. Gonos</p>