Adenoviral Vectors for Gene Therapy

Specificaties
Gebonden, blz. | Engels
Elsevier Science | 2016
ISBN13: 9780128002766
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Elsevier Science e druk, 2016 9780128002766
€ 209,80
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Samenvatting

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Specificaties

ISBN13:9780128002766
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>1. Adenovirus Structure<br>2. Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms<br>3. Adenovirus Replication<br>4. Adenoviral Vector Construction I: Mammalian Systems<br>5. Adenoviral Vector Construction II: Bacterial Systems<br>6. Upstream Bioprocess for Adenovirus Vectors<br>7. Propagation of Adenoviral Vectors: Use of PER.C6™ Cells<br>8. Purification of Adenovirus<br>9. Targeted Adenoviral Vectors I: Transductional Targeting<br>10. Targeted Adenoviral Vectors III: Transcriptional Targeting<br>11. Adenoviral Vector Targeting via Mitigation of Liver Sequestration<br>12. Molecular Design of Oncolytic Adenoviruses<br>13. Conditionally Replicative Adenoviruses—Clinical Trials<br>14. Innate Immune Response to Adenovirus Vector Administration In Vivo<br>15. Antibodies against Adenoviruses<br>16. Methods to Mitigate Immune Responses to Adenoviral Vectors<br>17. Helper-Dependent Adenoviral Vectors<br>18. Hybrid Adenoviral Vectors<br>19. Xenogenic Adenoviral Vectors<br>20. Engineering Chimeric Adenoviruses: Exploiting Virus Diversity for Improved Vectors, Vaccines, and Oncolytics<br>1. Introduction<br>22. Adenoviral Vectors Vaccine: Capsid Incorporation of Antigen<br>23. Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer<br>24. In Situ Vaccination with Adenoviral Vectors to Treat Cancer<br>25. Utility of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease<br>26. Adenoviral Vectors for Pulmonary Disease (Pulmonary Vascular Disease)<br>27. Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases<br>28. Animal Models of Gene Therapy for Cardiovascular Disease<br>29. Polymer-Anchored Adenovirus as a Therapeutic Agent for Cancer Gene Therapy<br>30. Adenoviral Vectors for RNAi Delivery<br>31. Imaging and Adenoviral Gene Therapy<br>32. Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective</p>
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        Adenoviral Vectors for Gene Therapy