<p>Foreword by Jane Visvader and Stanton GersonSection I. CSC Overview and Methodology</p> <p>1. Introduction: Cancer Stem Cells Siddhartha S. Mitra, Joy He, Rogelio Esparza, Gregor Hutter, Samuel H. Cheshier and Irving Weissman</p> <p>2. Overview: Cancer Stem Cell Self-RenewalMaider Zabala, Neethan A. Lobo, Dalong Qian, Linda J. van Weele, Diane Heiser and Michael F. Clarke</p> <p>3. Enrichment and Interrogation of Cancer Stem CellsAwad Jarrar, Anastasia Chumakova, Masahiro Hitomi, Justin Lathia</p> <p>Section II. CSCs in Representative Organ systems</p> <p>4. Critical Updates to the Leukemia Stem Cell ModelYogen Saunthararajah</p> <p>5. Breast cancer stem cells and the move toward high resolution stem cell systemsBenjamin T. Spike</p> <p>6. Lung Cancer Stem Cells: Drivers of Genetically and Histologically Complex DiseaseChristine M. Fillmore and Carla F. Kim</p> <p>7. Colorectal cancer stem cellsSumaiyah Rehman, Jennifer Haynes, Evelyne Lima-Fernandes, Akshita Puri, Andrew Haller, Cherry Leung, Lauren Agro, Yadong Wang, and Catherine A. O’Brien</p> <p>8. Targeting Bladder Cancer Stem Cells: One-Step Closer To The Clinic?Antonina Kurtova and Keith Syson Chan</p> <p>9. Cancer Stem Cells as New therapeutic Targets for Ovarian CancerYinu Wang, Fang Fang, Salvatore Condello, Daniela Matei and Kenneth P. Nephew</p> <p>Section III. CSC Features and Mechanisms</p> <p>10. Understanding Cancer Cells of Origin in Cutaneous TumorsHyeongsun Moon, Leanne R. Donahue, Andrew C. White</p> <p>11. Asymmetric Division of Cancer Stem CellsClaudia Petritsch and Xiling Shen</p> <p>12. Metastasis and Metastatic Cells: A Historical Perspective and Current Analysis Kiera Rycaj and Dean G. Tang</p> <p>13. Metastasis and Evasion from the Host Immune ResponsesAvijeet Chopra, Xia Liu, Huiping Liu</p> <p>14. Cancer Stem Cells and Tumor Associated MacrophagesWenchao Zhou and Shideng Bao</p> <p>15. The Mechanisms of Therapy Resistance in Cancer Stem CellsChi-Hsuan Chang and Jeffrey M. Rosen</p> <p>16. Adipose tissue-derived stem cells in regenerative medicine and impact on cancerPraveena S. Thiagarajan, Justin D. Lathia, and Ofer Reizes</p> <p>Section IV. Clinical Applications</p> <p>17. From Research to the Clinic: Targeting Stem Cell Pathways in CancerAustin Gurney and Timothy Hoey</p> <p>18. Targeted Therapies for Glioma Stem CellsSwetha J. Sundar, James Wright, Jason K. Hseih & Andrew E. Sloan</p> <p>19. Circulating tumor cells, cancer stem cells, and emerging microfluidic detection technologies with clinical applicationsMolly Kozminsky and Sunitha Nagrath</p>