Platelets

<p>PART I: Platelet Biology<br>1. The Evolution of Mammalian Platelets<br>2. Megakaryocyte Development and Platelet Formation<br>3. The Structure of Resting and Activated Platelets<br>4. Platelet Glycobiology and the Control of Platelet Function and Lifespan<br>5. Platelet Genomics<br>6. Platelet MicroRNAs<br>7. The Platelet Transcriptome in Health and Disease<br>8. The Platelet Proteome<br>9. Platelet Receptors<br>10. The Glycoprotein Ib-IX-V Complex<br>11. GPVI and CLEC-2<br>12. Integrin αIIbβ3<br>13. Protease-Activated Receptors<br>14. The Platelet P2 Receptors<br>15. Platelet Inhibitory Receptors<br>16. Interactions Between Platelets, Leukocytes, and the Endothelium<br>17. Inhibition of Platelet Function by the Endothelium<br>18. Platelet Signal Transduction<br>19. Platelet Secretion<br>20. Hemostatic Thrombus Formation in Flowing Blood<br>21. Interactions Between Platelets and the Coagulation System<br>22. Platelet-Derived Extracellular Vesicles<br>23. Regulation of Fibrinolysis by Platelets<br>24. The Role of Platelets in Angiogenesis<br>25. Platelet Function in the Newborn</p> <p>PART II: The Role of Platelets in Disease<br>26. The Role of Platelets in Atherothrombosis<br>27. The Role of Platelets in Diabetes Mellitus<br>28. The Role of Platelets in Inflammation<br>29. The Role of Platelets in Antimicrobial Host Defense<br>30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion<br>31. The Role of Platelets in Sickle Cell Disease</p> <p>PART III: Clinical Tests of Platelet Function<br>32. Platelet Counting<br>33. Clinical Tests of Platelet Function<br>34. Platelet Aggregation<br>35. Flow Cytometry<br>36. Laboratory Monitoring of Antiplatelet Therapy<br>37. Platelet Function Testing in Clinical Research Trials</p> <p>PART IV: Disorders of Platelet Number and/or Function<br>38. The Clinical Approach to Disorders of Platelet Number and Function<br>39. Immune Thrombocytopenia (ITP)<br>40. Drug-Induced Thrombocytopenia<br>41. Heparin-Induced Thrombocytopenia<br>42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes<br>43. Thrombocytopenia in Pregnancy<br>44. Thrombocytopenia in the Newborn<br>45. Alloimmune Thrombocytopenia<br>46. Inherited Thrombocytopenias<br>47. Thrombocytosis and Essential Thrombocythemia<br>48. Inherited Disorders of Platelet Function<br>49. Acquired Disorders of Platelet Function</p> <p>PART V: Antiplatelet Therapy<br>50. Aspirin<br>51. P2Y12 Antagonists<br>52. αIIbβ3 (GPIIb-IIIa) Antagonists<br>53. PAR-1 Antagonists<br>54. Phosphodiesterase Inhibitors<br>55. Novel Antiplatelet Therapies<br>56. Antiplatelet Drugs in the Management of Coronary Artery Disease<br>57. Antiplatelet Drugs in the Management of Cerebral Ischemia<br>58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease<br>59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications<br>60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Children</p> <p>PART VI: Therapy to Increase Platelet Numbers and/or Function<br>61. Thrombopoietin Receptor Agonists<br>62. Desmopressin (DDAVP)<br>63. Factor VIIa<br>64. Platelet Transfusion Medicine<br>65. Therapeutic Platelet-Rich Plasma in Wound Healing<br>66. Stem Cell-Derived Platelets<br>67. Gene Therapy for Platelet Disorders</p>