Part I - Epidemiology and diagnosis<br>1. History of systemic lupus erythematosus with an emphasis on certain recent major issues<br>Shu Man Fu and Felicia Gaskin<br>2. The patient<br>Donald E. Thomas, Jr.<br>3. A plea of a young patient to the lupus experts<br>Brianna Fitzpatrick<br>4. Epidemiology<br>Manuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcón<br>5. Measuring disease activity<br>Joan T. Merrill<br>6. Disease development and outcome<br>Mary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman<br>7. Socioeconomic aspects of SLE<br>Titilola Falasinnu and Julia F. Simard<br>8. Biomarkers in systemic lupus erythematosus<br>Stacy P. Ardoin and Wael N. Jarjour<br><br>Part II - Pathogenesis<br>9. Overview of the pathogenesis of systemic lupus erythematosus<br>Antonio La Cava<br>10. System lupus erythematosus and the environment<br>Soad Haj Yahia and Nancy Agmon-Levin<br>11. Genes and genetics in human SLE<br>Mara L. Lennard Richard and Betty P. Tsao<br>12. Monogenic lupus<br>Mindy S. Lo<br>13. Hormones<br>Takayuki Katsuyama and Vaishali R. Moulton<br>14. Clinical aspects of the complement system in systemic lupus erythematosus<br>John P. Atkinson, M. Kathryn Liszewski and C. Yung Yu<br>15. T cells<br>Florencia Rosetti and José C. Crispín<br>16. B cells in SLE<br>Andreia C. Lino and Thomas Dörner<br>17. Neutrophils in systemic lupus erythematosus<br>Amr H. Sawalha<br>18. The role of dendritic cells in systemic lupus erythematosus<br>Manon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco<br>19. Cytokines<br>Takayuki Katsuyama and Vaishali R. Moulton<br>20. RNA/DNA sensing in SLE—Toll-like receptors and beyond<br>Caroline A. Jefferies and Amir Sharabi<br>21. The role of interferons in systemic lupus erythematosus<br>Ruth Fernandez-Ruiz and Timothy Niewold<br>22. Fcγ receptors in autoimmunity and endorgan damage<br>T. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas<br>23. Apoptosis, autophagy, and necrosis<br>Roberto Caricchio<br>24. Infections in early systemic lupus erythematosus pathogenesis<br>Rebecka Bourn, Samantha Slight-Webb and Judith A. James<br>25. Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome<br>Teri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel<br>26. Origin of autoantibodies<br>Westley H. Reeves, Shuhong Han and Haoyang Zhuang<br>27. Anti-DNA antibodies<br>Susan Malkiel, Yemil Atisha-Fregoso and Betty Diamond<br>28. Antihistone and antispliceosome antibodies<br>Minoru Satoh, Marvin J. Fritzler and Edward K.L. Chan<br>29. Immune complexes in systemic lupus erythematosus<br>Keiju Hiromura and Masaomi Nangaku<br>30. MicroRNA in systemic lupus erythematosus<br>Bo Qu, Xiaoyue Jiang and Nan Shen<br>31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycin<br>Andras Perl<br>32. Epigenetics<br>Christian M. Hedrich<br>33. What do mouse models teach us about human SLE?<br>Ziaur S.M. Raman and Chandra Mohan<br>34. Genes and genetics of murine systemic lupus erythematosus<br>Dwight H. Kono and Argyrios N. Theofilopoulos<br><br>Part III - Mechanisms of tissue damage<br>35. Mechanisms of renal damage in systemic lupus erythematosus<br>Shu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin<br>36. Mechanisms of vascular damage in systemic lupus erythematosus<br>Sarfaraz A. Hasni and Mariana J. Kaplan<br>37. The mechanism of skin damage<br>Xin Huang, Haijing Wu, Christopher Chang and Qianjin Lu<br>38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus<br>David Hunt<br><br>Part IV - Clinical aspects of the disease<br>39. Constitutional symptoms and fatigue in systemic lupus erythematosus<br>Syahrul Sazliyana Shaharir and Caroline Gordon<br>40. The musculoskeletal system in SLE<br>Maria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie<br>41. Cutaneous lupus erythematosus<br>Annegret Kuhn, Aysche Landmann and Gisela Bonsmann<br>42. The clinical evaluation of kidney disease in systemic lupus erythematosus<br>Brad H. Rovin, Isabelle Ayoub and Swati Arora<br>43. The pathology of lupus nephritis<br>Isaac Ely Stillman<br>44. Cardiovascular disease in systemic lupus erythematosus: an update<br>Stephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi<br>45. The lung in systemic lupus erythematosus<br>Lindsy Forbess, Daniel J. Wallace and Caroline Jefferies<br>46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus<br>Chi Chiu Mok<br>47. Systemic lupus erythematosus and infections<br>Amy Devlin and Robert H. Shmerling<br>48. Malignancies in systemic lupus erythematosus<br>Alexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky<br>49. The nervous system in systemic lupus erythematosus<br>David Hunt<br>50. Overlap syndromes<br>Eric L. Greidinger<br>51. Systemic lupus erythematosus and the eye<br>Erika M. Damato, Philip I. Murray and Alastair K.O. Denniston<br>52. Fertility and pregnancy in systemic lupus erythematosus<br>Bonnie L. Bermas and Lisa R. Sammaritano<br>53. Neonatal lupus<br>Clinical spectrum, biomarkers, pathogenesis, and approach to treatment<br>Jill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright<br>54. Incomplete lupus syndromes<br>Nancy J. Olsen<br>55. Lupus in children<br>Mindy S. Lo<br>56. Drug-induced lupus<br>Robert L. Rubin<br>57. Vasculitis in lupus<br>Anisur Rahman<br><br>Part V - Antiphospholipid Syndrome<br>58. Pathogenesis of antiphospholipid syndrome<br>Olga Amengual and Tatsuya Atsumi<br>59. Antibodies and diagnostic tests in antiphosholipid syndrome<br>Cecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni<br>60. Clinical manifestations<br>Miyuki Bohgaki and Takao Koike<br>61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosus<br>Robert G. Lahita and Trina Pal<br>62. Value of antimalarial drugs in the treatment of lupus<br>Fadi Hassan, Mohammad E. Naffaa and Ziv Paz<br>63. Systemic glucocorticoids<br>Zahi Touma and Murray B. Urowitz<br>64. Cytotoxic drug treatment<br>Eleni A. Frangou, George Bertsias and Dimitrios T. Boumpas<br>65. Treatment of antiphospholipid syndrome<br>Savino Sciascia and Munther Khamashta<br>66. New treatments of systemic lupus erythematosus<br>Vasileios C Kyttaris<br>67. Repositioning drugs for systemic lupus erythematosus<br>Kathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer