Atkinson's Principles of Clinical Pharmacology

<p>1. Introduction to Clinical Pharmacology</p> <p>Arthur John Atkinson Jr., Juan J. L. Lertora and Shiew Mei Huang</p> <p>2. Clinical Pharmacokinetics</p> <p>Arthur John Atkinson Jr.</p> <p>3. Compartmental Analysis of Drug Distribution</p> <p>Arthur John Atkinson Jr.</p> <p>4. Drug Absorption and Bioavailability</p> <p>Arthur John Atkinson Jr.</p> <p>5. Effect of Renal Disease on Pharmacokinetics</p> <p>Thomas D. Nolin, Albert Dreisbach and Juan J. L. Lertora</p> <p>6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy</p> <p>Arthur John Atkinson Jr., Thomas D. Nolin and John Allen</p> <p>7. Effect of Liver Disease on Pharmacokinetics</p> <p>Juan J. L. Lertora, Robert A. Branch and Nathalie K. Zgheib</p> <p>8. Non-Compartmental and Compartmental Approaches to Pharmacokinetic Data Analysis</p> <p>Paolo Vicini</p> <p>9. Population Pharmacokinetics</p> <p>Raymond Miller and Ophelia Yin</p> <p>10. Pathways of Drug Metabolism</p> <p>Nina Isoherranen and R. Scott Obach</p> <p>11. Methods of Analysis of Drugs and Drug Metabolites</p> <p>Mark Edward Arnold and Brian Booth</p> <p>12. Clinical Pharmacogenomics</p> <p>Anuradha Ramamoorthy, Tristan Sissung and Michael Pacanowski</p> <p>13. Mechanisms and genetics of drug transport</p> <p>Lei Zhang, Sook Wah Yee, Osatohanmwen Enogieru, Shiew Mei Huang and Kathleen Giacomini</p> <p>14. drug-drug interactions</p> <p>Aleksandra Galetin, Lei Zhang, A. David Rodrigues and Shiew Mei Huang</p> <p>15. Biochemical Mechanisms of Drug Toxicity</p> <p>Arthur John Atkinson Jr., Jack Uetrecht, Denis M. Grant and Peter G. Wells</p> <p>16. pharmacogenomic mechanisms of drug toxicity</p> <p>Shiew Mei Huang, Ligong Chen and Kathleen Giacomini</p> <p>17. Biomarkers in Drug Development</p> <p>Robert N. Schuck, Jana G. Delfino, Christopher Leptak and John A. Wagner</p> <p>18. imaging in drug development</p> <p>Owen Carmichael</p> <p>19. dose-effect and concentration-effect analysis</p> <p>Juan J. L. Lertora, Yaning Wang, Jiang Liu and Justin C. Earp</p> <p>20. time course of drug response</p> <p>Nick Holford</p> <p>21. disease progress models</p> <p>Diane Renee Mould, Nick Holford and Carl Peck</p> <p>22. Pharmacological Differences between Men and Women</p> <p>Mary F. Paine and Karen Dinh Vo</p> <p>23. drug therapy in pregnant and nursing women</p> <p>Catherine Stika and Marilynn C. Frederiksen</p> <p>24. pediatric clinical pharmacology and therapeutics</p> <p>Bridgette Jones, John N. van den Anker, Gilbert J. Burckart and Gregory Kearns</p> <p>25. Medication Therapy in Older Adults</p> <p>S. W. Johnny Lau, Danijela Gnjidic and Darrell Abernethy</p> <p>26. clinical analysis of adverse drug reactions</p> <p>Christine Chamberlain, Cindy Kortepeter and Monica Munoz</p> <p>27. Quality Assessment of Drug Therapy</p> <p>Charles Edward Daniels</p> <p>28. portfolio and project planning and management in the drug discovery evaluation, development, and regulatory review process</p> <p>Charles V. Grudzinskas, Michael Dyszel, Khushboo Sharma and Charles T. Gombar</p> <p>29. Drug Discovery</p> <p>Thomas Bateman</p> <p>30. Non-Clinical Drug Development</p> <p>Chris H. Takimoto</p> <p>31. pre-clinical prediction of human pharmacokinetics</p> <p>Malcolm Rowland</p> <p>32. Phase I Clinical Studies</p> <p>Robert Joseph Noveck and Martina D. Sahre</p> <p>33. pharmacokinetic and pharmacodynamic considerations in the development of biotechnology products and large molecules</p> <p>Pamela Garzone and Yow-Ming C. Wang</p> <p>34. Design of Clinical Development Programs</p> <p>Megan Gibbs, Bengt Hamren, Helen Tomkinson, Renee Bailey Iacona and David Boulton</p> <p>35. the role of the FDA in guiding drug development;</p> <p>Elimika Pfuma Fletcher, Rajanikanth Madabushi, Chandrahas Sahajwalla, Lawrence J. Lesko and Shiew Mei Huang</p> <p>36. Emerging Clinical Pharmacology Topics in Drug Development and Precision Medicine</p> <p>Qi Liu, Jack A. Gilbert, Hao Zhu, Shiew Mei Huang, Elizabeth Kunkoski, Promi Das, Kimberly Bergman, Mary Buschmann and M Khair ElZarrad</p> <p>Appendix I</p> <p>Appendix II</p>