<h2>Brief Contents</h2> <div class="c-section-headers-non-traditional-number-list_container"> <h3>PART 1: FOUNDATIONS OF PATHOPHYSIOLOGY</h3> <ol> <li>Introduction to the Basics of Pathophysiology</li> <li>Genetics, Genomics, and Epigenomics</li> <li>Environmental Influences on Disease and Injury</li> <li>Stress and Adaptation</li> </ol> <h3>PART 2: RISKS UNDERLYING THE LEADING CAUSES OF MORBIDITY AND MORTALITY</h3> <ol start="5"> <li>Health Risks of Obesity and Physical Inactivity</li> <li>Risks Related to Substance Use Disorders</li> <li>Risks Related to Sleep Alterations</li> </ol> <h3>PART 3: FLUID, ELECTROLYTE, AND ACID-BASE IMBALANCES</h3> <ol start="8"> <li>Fluid and Electrolyte Imbalances</li> <li>Acid-Base Imbalances</li> </ol> <h3>PART 4: CELL INJURY, INFLAMMATION, AND ALTERATIONS OF CELL GROWTH AND REGULATION</h3> <ol start="10"> <li>Mechanisms of Cell Injury and Aging</li> <li>Inflammation</li> <li>Neoplasia</li> </ol> <h3>PART 5: INFECTION AND DISORDERS OF IMMUNITY</h3> <ol start="13"> <li>Mechanisms of Infection and Host Protection</li> <li>Hypersensitivity and Autoimmune Disorders</li> <li>Immunodeficiency Disorders</li> <li>Disorders of White Blood Cells</li> </ol> <h3>PART 6: DISORDERS OF OXYGENATION</h3> <ol start="17"> <li>Restrictive Lung Disorders</li> <li>Obstructive Lung Disorders</li> <li>Neoplastic, Infectious, and Pulmonary Vascular Lung Disorders</li> <li>Respiratory Failure</li> <li>Disorders of Oxygen Transport</li> </ol> <h3>PART 7: DISORDERS OF PERFUSION</h3> <ol start="22"> <li>Alterations of Hemostasis</li> <li>Vascular Disorders</li> <li>Coronary Circulation Disorders</li> <li>Cardiac Structural Disorders</li> <li>Heart Failure</li> <li>Disorders of Circulation within the Central Nervous System</li> <li>Shock and Multiple Organ Dysfunction Syndrome</li> </ol> <h3>PART 8: DISORDERS OF MOOD AND COGNITION</h3> <ol start="29"> <li>Disorders of Emotional Regulation</li> <li>Disorders of Neurodevelopment and Neurocognition</li> </ol> <h3>PART 9: DISORDERS OF SENSORY PERCEPTION AND THERMOREGULATION</h3> <ol start="31"> <li>Disorders of Hearing, Balance, and Vision</li> <li>Pain, Neuropathy, and Headache</li> <li>Disorders of Thermoregulation</li> </ol> <h3>PART 10: DISORDERS OF MOBILITY</h3> <ol start="34"> <li>Disorders Affecting Motor Function</li> <li>Acute Musculoskeletal Disorders</li> <li>Chronic Musculoskeletal Disorders</li> </ol> <h3>PART 11: DISORDERS OF ENDOCRINE REGULATION</h3> <ol start="37"> <li>Diabetes Mellitus</li> <li>Thyroid, Parathyroid, and Adrenal Disorders</li> </ol> <h3>PART 12: ALTERED TISSUE INTEGRITY</h3> <ol start="39"> <li>Tissue and Wound Healing</li> <li>Acute Skin Disorders</li> <li>Chronic Skin Disorders</li> </ol> <h3>PART 13: DISORDERS OF DIGESTION, METABOLISM, AND ELIMINATION</h3> <ol start="42"> <li>Disorders of the Upper and Lower Gastrointestinal System</li> <li>Disorders of the Exocrine Pancreatic and Hepatobiliary Systems</li> <li>Liver Failure</li> <li>Disorders of Kidney and Urinary Tract Structure and Function</li> <li>Acute Kidney Injury and Chronic Kidney Disease</li> </ol> <h3>PART 14: DISORDERS OF SEXUALITY AND REPRODUCTION</h3> <ol start="47"> <li>Disorders of the Female Reproductive System</li> <li>Disorders of the Male Reproductive System</li> <li>Sexually Transmitted Infections</li> </ol> <h3>PART 15: TRAUMA AND MULTISYSTEM CONDITIONS</h3> <ol start="50"> <li>Mechanisms of Traumatic Injury</li> <li>The Pathophysiology of Primary and Secondary Traumatic Injury</li> <li>Biologic, Chemical, and Radiologic Agents of Disease</li> <li>Pathophysiology at the End of Life</li> </ol> </div>