<p>1 Normal Sleep and Its Variants<br>1. History of Sleep Physiology and Medicine<br>2. Normal Human Sleep: An Overview<br>3. Normal Aging<br>4. Daytime Sleepiness and Alertness<br>5. Sleep Deprivation</p> <p>2 Sleep Mechanisms and Phylogeny<br>6. Introduction/Defining Sleep<br>7. Neural Control of Sleep in Mamma Is<br>8. Rapid Eye Movement Sleep Control and Function<br>9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep<br>10. Evolution of Mammalian Sleep<br>11. Sleep in Nonmammalian Vertebrates</p> <p>3 Genetics and Genomic Basis of Sleep<br>12. Introduction: Genetics and Genomics of Sleep<br>13. Genetics and Genomics of Circadian Clocks<br>14. Genetics and Genomic Basis of Sleep in Simple Model Organisms<br>15. Genetic and Genomic Basis of Sleep in Rodents<br>16. Genetics and Genomic Basis of Sleep in Healthy Humans<br>17. Genetics and Genomic Basis of Sleep Disorders in Humans</p> <p>4 Physiology in Sleep<br>18. Introduction to Physiology in Sleep<br>19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep<br>20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation<br>21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders<br>22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep<br>23. Respiratory Physiology Understanding the Control of Ventilation<br>24. Physiology of Upper and lower Airways<br>25. 5 Respiratory Physiology Sleep at High Altitude<br>26. Sleep and Host Defense<br>27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances<br>28. Thermoregulation in Sleep and Hibernation<br>29. Memory Processing in Relation to Sleep<br>30. Sensory and Motor Processing during Sleep and Wakefulness<br>31. Local and Use-Dependent Aspects of Sleep<br>32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury</p> <p>5 Chronobiology<br>33. Introduction<br>34. Master Circadian Clock and Master Circadian Rhythm<br>35. Anatomy of the Mammalian Circadian Sys tern<br>36. Physiology of the Mammalian Circadian System<br>37. Human Circadian Timing System and Sleep-Wake Regulation<br>38. Sleep Homeostasis and Models of Sleep Regulation<br>39. Circadian Rhythms in Sleepiness, Alertness, and Performance<br>40. Central and Peripheral Circadian Clocks<br>41. Circadian Dysregulation and Cardiometabolic and Immune Health<br>42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health<br>43. Circadian Disorders of the Sleep-Wake Cycle</p> <p>6 Pharmacology<br>44. Introduction<br>45. Adenosinergic Control of Sleep<br>46. Catecholamines<br>47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias<br>48. Histamine<br>49. Orexin/Hypocretin<br>50. Serotonin and Sleep<br>51. Melatonin<br>52. Opioid Actions on Sleep and Breathing<br>53. Clinical Pharmacology of Drugs that Affect Sleep and Wake</p> <p>7 Psychobiology and Dreaming<br>54. Introduction<br>55. Why We Dream<br>56. Dream Content: Quantitative Findings<br>57. Neural Correlates of Dreaming<br>58. The Neurobiology of Dreaming<br>59. Lucid Dreaming<br>60. What Is the Function of Nightmares?<br>61. Dreams and Nightmares in Posttraumatic Stress Disorder<br>62. Incorporation of Waking Experiences into Dreams<br>63. Emotion, Motivation, and Reward in Relation to Dreaming<br>64. Dreaming during Pregnancy</p> <p>8 Impact, Presentation, and Diagnosis<br>65. Approach to the Patient with Disordered Sleep<br>66. Cardinal Manifestations of Sleep Disorders<br>67. Physical Examination in Sleep Medicine<br>68. Clinical Tools and Tests in Sleep Medicine<br>69. Classification of Sleep Disorders<br>70. Epidemiology of Sleep Medicine<br>71. Sleep Medicine, Public Policy, and Public Health</p> <p>9 Legal Aspects of Sleep Medicine<br>72. Introduction<br>73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence<br>74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them<br>75. Legal Aspects of Fatigue- and Safety-Sensitive Professions<br>76. Sleep Medicine Clinical Practice and Compliance— United States<br>77. Sleep Medicine Clinical Practice and Compliance—Europe</p> <p>10 Occupational Sleep Medicine<br>78. Introduction<br>79. Performance Deficits During Sleep Loss and Their Operational Consequences<br>80. Sleep and Sleep Disorders in Operational Settings<br>81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder<br>82. Fatigue Countermeasures<br>83. Sleep, Sleepiness, and Performance Prediction Modeling<br>84. Fatigue RiskManagemen f Systems<br>85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue RiskManagemenf<br>86. Fatigue Proofing<br>87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions<br>88. Assessment of the Occupational Sleep Medicine Field</p> <p>11 Insomnia<br>89. Advances in Insomnia Pathophysiology and Treatment: An Introduction<br>90. Insomnia: Epidemiology, Risk Factors, and Health Disparities<br>91. Etiology and Pathophysiology of Insomnia<br>92. Pediatric Insomnia and Its Developmental Trajectories<br>93. Insomnia Diagnosis, Assessment, and Evaluation<br>94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health<br>95. Behavioral Treatment I: Therapeutic Approaches and Implementation<br>96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination<br>97. Behavioral Treatment III: Digital and Telehealth Approaches<br>98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation<br>99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications<br>100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia</p> <p>12 Neurologic Disorders<br>101. Introduction<br>102. Parkinsonism<br>103. Sleep-Wake Disturbances and Stroke<br>104. Sleep and Neuromuscular Diseases<br>105. Alzheimer Disease and Other Demen tias<br>106. Epilepsy, Sleep, and Sleep Disorders<br>107. Sleep and Headache<br>108. Sleep Disorders after Traumatic Brain Injury<br>109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)</p> <p>13 Hypersomnias<br>110. Central Disorders of Hypersomnolence<br>111. Narcolepsy: Pathophysiology and Genetic Predisposition<br>112. Narcolepsy: Diagnosis and Management<br>113. Idiopathic Hypersomnia<br>114. Kleine-Levin Syndrome</p> <p>14 Parasomnias<br>115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach<br>116. Disorders of Arousal<br>117. Sleep-Related Eating Disorder<br>118. Rapid Eye Movement Sleep Parasomnias<br>119. Nightmares and Dream Disturbances<br>120. Other Parasomnias<br>121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep<br>122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations</p> <p>15 Sleep Breathing Disorders<br>123. Introduction<br>124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology<br>125. Central Sleep Apnea: Diagnosis and Management<br>126. Anatomy and Physiology of Upper Airway Obstruction<br>127. Snoring and Pathologic Upper Airway Resistance Syndromes<br>128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics<br>129. Deep Phenotyping of Sleep Apnea<br>130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea<br>131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management<br>132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea<br>133. Pharmacologic Treatments for Obstructive Sleep Apnea<br>134. Alternative Strategies to Management of Sleep-Disordered Breathing<br>135. Brain Health in Sleep Apnea: Cognition, Performance, Mechanisms, and Treatment<br>136. Obstructive Sleep Apnea and Metabolic Disorders<br>137. Overlap Syndromes of Sleep and Breathing Disorders<br>138. Obesity-Hypoventilation Syndrome<br>139. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery<br>140. Advanced Modes of Positive Pressure Therapy for Sleep-Disordered Breathing<br>141. Sleep and Breathing at High Altitude<br>142. Evolution of Sleep-Disordered Breathing across the Adult Years</p> <p>16 Cardiovascular Disorders<br>143. Introduction<br>144. Sleep-Related Cardiac Risk<br>145. Cardiac A rrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy<br>146. Cardiovascular Effects of Sleep-Related Breathing Disorders<br>147. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea<br>148. Coronary Artery Disease and Obstructive Sleep Apnea<br>149. Heart Failure<br>150. Sleep-Disordered Breathing and Stroke<br>151. Insomnia and Cardiovascular Disease</p> <p>17 Other Medical Disorders<br>152. Introduction<br>153. Sleep and Cancer across the Life Span<br>154. Fibromyalgia and Chronic Fatigue Syndromes<br>155. Endocrine Disorders<br>156. Pain and Sleep<br>157. Sleep and Chronic Kidney Disease<br>158. Sleep in the Critically III Patient<br>159. Perioperative Sleep Medicine<br>160. Sleep and Gastrointestinal Health</p> <p>18 Psychiatric Disorders<br>161. Introduction<br>162. Emotion and Sleep<br>163. Anxiety Disorders and Posttraumatic Stress Disorder<br>164. Affearve Disorders<br>165. Schizophrenia and Sleep<br>166. Substance Abuse</p> <p>19 Dentistry and Otorhinolaryngology<br>167. Dentistry and Otorhinolaryngology in Sleep Medicine: Below the BraiAtttpd Above the Larynx<br>168. Oronasopharyngeal Growth and Malformations with Orthodontic Management<br>169. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences<br>170. Assessment of Sleep Bruxism<br>171. Management of Sleep Bruxism: Psychological, DentaL and Medical Approaches in Adults<br>172. Orofacial Pain/Temporomandibular Disorders in Relation to Sleep Bruxism and Breathing Disorders<br>173. Oral Appliances for the Treatment of Sleep-Disordered Breathing<br>174. Anesthesia in Upper Airway Surgery<br>175. Upper Airway Surgery to Treat Obstructive Sleep- Disordered Breathing<br>176. Pharmacotherapy and Behavioral Complementary, and Alternative Medicine for Sleep Bruxism</p> <p>20 From Childhood to Adulthood<br>177. Overview: Transition from Pediatric-Oriented to Adult-Oriented Health Care in Sleep Medicine<br>178. Sleep-Related Breathing Disorders in Children<br>179. Neuromuscular and Neurological Disorders<br>180. Transitional Care for Adolescents with Narcolepsy and Other Central Disorders of Hypersomnolence<br>181. Congenital Heart Disease<br>182. Sleep in Intersex and Transgender Individuals</p> <p>21 Sleep in Women<br>183. Introduction<br>184. Sex Effects and Differences in Circadian Rhythms and Sleep<br>185. The Menstrual Cycle, Sleep, and Circadian Rhythms<br>186. Sleep and Sleep Disorders Associated with Pregnancy<br>187. Sleep-Disordered Breathing in Pregnancy<br>188. Postpartum Period and Early Parenthood<br>189. Sleep and Menopause</p> <p>22 Sleep Medicine in the Elderly<br>190. Introduction<br>191. Psychiatric and Medical Comorbidities and E ffects oiMedications in Older Adults<br>192. Obstructive Sleep Apnea in Older Adults<br>193. Insomnia in Older Adults<br>194. Orcadian Rhythms in Older Adults<br>195. Sleep in Long-Term Care Settings</p> <p>23 Methodology<br>196. Section Introduction: Polysomnography and Beyond<br>197. Sleep Stage Scoring<br>198. Central Nervous System Arousals and the Cyclic Alternating Pattern<br>199. Neurologic Monitoring Techniques<br>200. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing and Cardiovascular Disorders<br>201. Sleep Telemedicine and Remote PAP Adherence Monitoring<br>202. Cardiopulmonary Coupling<br>203. Pulse Wave Analysis<br>204. Recording and Scoring Sleep-Related Movements<br>205. Home Sleep Testing for Sleep-Related Breathing Disorders<br>206. Consumer Sleep Tracking: Landscape and CTA/ANSI Performance Standards<br>207. Evaluating Sleepiness and Fatigue<br>208. The Assessment of Insomnia<br>209. Surveys, Sampling, and Polling Methods for Sleep and Public Health<br>210. Techniques for Clinical Assessment of Circadian Rhythm Disorders<br>211. Actigraphy Methods and Technical Issues<br>212. Imaging<br>213. COVID-19 and Sleep<br></p>