VOLUME 1<br>Introduction: Hepatobiliary and Pancreatic Surgery: Historical Perspective<br>PART 1 Liver, Biliary, and Pancreatic Anatomy and Physiology<br>1 Embryologic Development of the Liver, Biliary Tract, and Pancreas<br>2 Surgical and Radiologic Anatomy of the Liver, Biliary Tract, and Pancreas<br>3 Pancreatic Physiology and Functional Assessment<br>4 Assessment of Hepatic Function: Implications for Perioperative Outcome and Recovery<br>5 Liver Blood Flow: Physiology, Measurement, and Clinical Relevance<br>6 Liver Regeneration: Mechanisms and Clinical Relevance<br>7 Liver Fibrogenesis: Mechanisms and Clinical Relevance<br>8 Bile Secretion and Pathophysiology of Biliary Tract Obstruction<br>9A Molecular and cell Biology of Hepatopancreatobiliary Disease: Introduction and Basic Principles<br>9B Molecular and Cell Biology of Liver Carcinogenesis and Hepatitis<br>9C Advances in the Molecular Characterization of Liver Tumors<br>9D Advances in the Molecular Characterization of Pancreatic Cancer and Pre-malignant Lesions<br>9E Advances in the Molecular Characterization of Biliary Tract and Gallbladder Cancer<br>10 Fundamentals of Liver and Pancreas Immunology<br>11 Infections in Hepatic, Biliary, and Pancreatic Surgery<br>PART 2 Diagnostic Techniques<br>12 Clinical Investigation of Hepatopancreatobiliary and Pancreatic Disease<br>13 Cross-Sectional Imaging of Liver, Biliary, and Pancreatic Disease: Introduction and Basic Principles<br>14 Imaging Features of Benign and Malignant Liver Tumors and Cysts<br>15 Imaging Features of Metastatic Liver Cancer<br>16 Imaging Features of Gallbladder and Biliary Tract Disease<br>17 Imaging Features of Benign and Malignant Pancreatic Disease<br>18 The Role of Nuclear Medicine in Diagnosis and Management of Hepatopancreatobiliary Diseases<br>19 Emerging Techniques in Diagnostic Imaging<br>20 Direct Cholangiography: Approaches, Techniques, and Current Role<br>21 Diagnostic Angiography in Hepatobiliary and Pancreatic Disease: Indications<br>22 Endoscopic Ultrasound of the Biliary Tract and Pancreas<br>23 Image-Guided Liver Biopsy<br>24 Intraoperative Diagnostic Techniques<br>PART 3 Anesthetic Management, Pre- and Postoperative Care<br>25 Liver and Pancreatic Surgery: Intraoperative Management<br>26 Nutrition and Perioperative Critical Care in the Hepatopancreatobiliary Surgery Patient<br>27 Enhanced Recovery Programs in Hepatobiliary Surgery<br>28 Postoperative Complications Requiring Intervention: Diagnosis and Management<br>29 The Impact of Hepatobiliary Interventions on Health and Quality of Life and Health<br>PART 4 Techniques of Biliary Tract Intervention: Radiologic, Endoscopic, and Surgical<br>30 Interventional Endoscopy for Biliary Tract Disease: Technical Aspects<br>31 Radiologic Hepatobiliary Interventions<br>32 Bile Duct Exploration and Biliary-Enteric Anastomosis<br>PART 5 Biliary Tract Disease<br>SECTION I Inflammatory, Infective, and Congenital<br>A Gallstones and Gallbladder<br>33 The Natural History of Symptomatic and Asymptomatic Gallstones<br>34 Cholecystitis<br>35 Percutaneous Treatment of Gallbladder Disease<br>36 Cholecystectomy Techniques and Postoperative Problems<br>37A Stones in the Bile Duct: Clinical Features and Open Surgical Approaches and Techniques<br>37B Stones in the Bile Duct: Minimally Invasive Surgical Approaches<br>37C Stones in the Bile Duct: Endoscopic and Percutaneous Approaches<br>38 Cholecystolithiasis and Stones in the Common Bile Duct: Which Approach and When?<br>39 Intrahepatic Stone Disease<br>B Biliary Stricture and Fistula<br>40 Extrahepatic Biliary Atresia<br>41 Primary Sclerosing Cholangitis<br>42 Benign Biliary Strictures and Biliary Fistulae<br>C Biliary Infection and Infestation<br>43 Cholangitis<br>44 Recurrent Pyogenic Cholangitis<br>45 Biliary Parasitic Disease<br>D Cystic Disease of the Biliary Tract<br>46 Bile Duct Cysts in Adults<br>SECTION II Neoplastic<br>A General<br>47 Tumors of the Bile Ducts: Pathologic Features<br>B Benign Tumors<br>48 Benign Tumors and Pseudotumors of the Biliary Tract<br>49 Tumors of the Gallbladder<br>50 Intrahepatic Cholangiocarcinoma<br>51A Extrahepatic Biliary Tumors<br>51B Perihilar Cholangiocarcinoma: Presurgical Management<br>52 Interventional Techniques in Hilar and Intrahepatic Biliary Strictures<br>PART 6 Pancreatic Disease<br>SECTION I Inflammatory, Infective, and Congenital<br>A Congenital Disorders<br>53 Congenital Disorders of the Pancreas: Surgical Considerations<br>B Pancreatitis<br>54 Definition and Classification of Pancreatitis<br>55 Etiology, Pathogenesis, and Diagnostic Assessment of Acute Pancreatitis<br>56 Management of Acute Pancreatitis and Pancreatitis-Related Complications<br>57 Etiology, Pathogenesis, and Diagnosis of Chronic Pancreatitis<br>58 Management of Chronic Pancreatitis: Conservative, Endoscopic, Surgical<br>SECTION II Neoplastic<br>A General<br>59 Tumors of the Pancreas and Ampulla<br>B Benign and Premalignant Tumors<br>60 Cystic Neoplasms of the Pancreas: Epidemiology, Clinical Features, Assessment, and Management<br>C Malignant Tumors<br>61 Pancreatic Cancer: Epidemiology<br>62 Pancreatic Cancer: Clinical Aspects, Assessment, and Management<br>63 Duodenal Adenocarcinoma<br>64 Pancreas as a Site of Metastatic Cancer<br>D Endocrine Tumors<br>65 Pancreatic Neuroendocrine Tumors: Classification, Clinical Picture, Diagnosis, and Therapy<br>66 Chemotherapy and Radiotherapy for Pancreatic Cancer: Adjuvant, Neoadjuvant, and Palliative<br>67 Palliative Treatment of Pancreatic and Periampullary Tumors<br>VOLUME 2<br>PART 7 Hepatic Disease<br>SECTION I Inflammatory, Infective, and Congenital<br>A Hepatitis<br>68 Chronic Hepatitis: Epidemiology, Clinical Features, and Management<br>69 Hepatic Steatosis, Steatohepatitis, and Chemotherapy-Related Liver Injury<br>B Liver Infection and Infestation<br>70 Pyogenic Liver Abscess<br>71 Amebiasis and Other Parasitic Infections<br>72 Hydatid Disease of the Liver<br>C Nonparasitic Liver Cysts<br>73 Simple Cysts and Polycystic Liver Disease: Clinical and Radiographic Features and Surgical and Nonsurgical Management<br>D Hepatic Cirrhosis, Portal Hypertension, and Hepatic Failure<br>74 Cirrhosis and Portal Hypertension: Pathologic Aspects<br>75 Nonhepatic Surgery in the Cirrhotic Patient<br>76 Portal Hypertension in Children<br>77 Management of Liver Failure<br>78 Support of the Failing Liver<br>79 Management of Ascites in Cirrhosis and Portal Hypertension<br>80 Medical Management of Bleeding Varices: Primary and Secondary Prophylaxis for Variceal Bleeding<br>81 Portal Hypertensive Bleeding: Acute Management<br>82 Portal Hypertensive Bleeding: Operative Devascularization<br>83 Portal Hypertensive Bleeding: the Role of Portosystemic Shunting<br>84 Techniques of Portasystemic Shunting: Selective and Nonselective Shunts<br>85 Transjugular Portosystemic Shunting (TIPS): Indications and Technique<br>86 Budd-Chiari Syndrome and Veno-Occlusive Disease<br>SECTION II Neoplastic<br>A General<br>87 Tumors of the Liver: Pathologic Aspects<br>B Benign and Premalignant Tumors<br>88A Benign Liver Lesions<br>88B Cystic Hepatobiliary Neoplasia<br>89 Hepatocellular Carcinoma<br>90 Hepatic Metastasis from Colorectal Cancer<br>91 Hepatic Metastasis from Neuroendocrine Cancers<br>92 Hepatic Metastasis from Noncolorectal Nonneuroendocrine Tumors<br>93 Hepatic Tumors in Childhood<br>D Treatment: Nonresectional<br>94A Hepatic Artery Embolization and Chemoembolization of Liver Tumors<br>94B Radioembolization for Liver Tumors<br>95 External Beam Radiotherapy for Liver Tumors<br>96A Ablative Treatment of Liver Tumors: Overview<br>96B Radiofrequency Ablation of Liver Tumors<br>96C Microwave Ablation and Irreversible Electroporation of Liver Tumors<br>96D Cryotherapy and Ethanol Injection<br>97 Regional Chemotherapy for Liver Tumors<br>98 Systemic Chemotherapy for Colorectal Liver Metastasis: Impact on Surgical Management<br>99 Advances in Systemic Therapy for Hepatocellular Carcinoma<br>100 Isolated Hepatic Perfusion for Unresectable Hepatic Metastases<br>E Treatment: Resection<br>101A Hepatic Resection: General Considerations<br>101B Hepatic Resection for Benign and Malignant Liver and Biliary Tract Disease: Indications and Outcomes<br>102A Parenchymal Preservation in Hepatic Resectional Surgery: Rationale, Indications and Outcomes<br>102B Segment-Oriented Anatomic Liver Resections: Indications and Outcomes<br>102C Preoperative Portal Vein Embolization: Indications, Technique, and Results<br>102D Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Indications and Outcomes<br>103 Adjuncts to Hepatic Resection: From Ultrasound Guidance to New Oncologic and Technical Horizons<br>PART 8 Liver and Pancreas Transplantation<br>SECTION I General<br>104 Liver and Pancreas Transplantation Immunobiology<br>SECTION II Indications<br>105 Liver Transplantation: Indications and General Considerations<br>106 Liver Transplantation: Perioperative Anesthetic Considerations<br>107 Liver Transplantation in Patients with Fulminant Hepatitis<br>108A Liver Transplantation for Hepatocellular Carcinoma<br>108B Liver Transplantation for Nonhepatocellular Malignant Disease<br>109 Orthotopic Liver Transplantation: Standard Donation After Brain Death, Donation After Cardiac Death, and Live Donor – Indications and Outcomes<br>110 Liver Transplantation in Children: Indications and Outcomes<br>111 Early and Late Complications of Liver Transplantation<br>112 Whole Organ Pancreas and Pancreatic Islet Transplantation<br>PART 9 Hepatobiliary Injury and Hemorrhage<br>113 Injuries to the Liver and Biliary Tract<br>114 Pancreatic and Duodenal Injuries<br>115 Aneurysm and Arteriovenous Fistula of the Liver and Pancreatic Vasculature<br>116 Hemobilia and Bilhemia<br>PART 10 Techniques of Pancreatic and Hepatic Resection and Transplantation<br>117A Pancreaticoduodenectomy<br>117B Distal and Central Pancreatectomy<br>117C Total Pancreatectomy<br>117D Transduodenal Resection of the Papilla of Vater<br>118A Major Hepatectomy and Extended Hepatectomy<br>118B Segmental Resection<br>119A Hepatic Resection for Biliary Tract Cancer: Gallbladder Cancer<br>119B Hilar Cholangiocarcinoma: Standard and Extended Resections of Perihilar Cholangiocarcinoma<br>120 Hepatic Resection in Cirrhosis<br>121 Resection Technique for Live Donor Transplantation<br>122 Vascular Reconstruction Techniques in Hepato-Pancreato-Biliary (HPB) Surgery<br>123 Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Techniques<br>124 Ex Vivo and in Situ Hypothermic Hepatic Resection<br>125 Techniques of Liver Replacement<br>126 Techniques of Pancreas Transplantation<br>127A Minimally Invasive Techniques in HPB Surgery: Laparoscopic and Robotic: General Principles and Considerations<br>127B Minimally Invasive Distal and Central Pancreatectomy<br>127C Minimally Invasive Pancreaticoduodenectomy<br>127D Minimally Invasive Segmental Hepatic Resection<br>127E Laparoscopic Major and Complex Liver Resection<br>127F Robotic-Assisted Placement of Hepatic Arterial Infusion Pump<br>128 Minimally Invasive Surgery Techniques in Transplantation