<p>PART I: Understanding, Controlling, and Preventing Infectious Diseases<br>Section A. Epidemiology and Control of Infectious Diseases<br>1. Principles of Epidemiology and Public Health<br>2. Pediatric Healthcare: Infection Epidemiology, Prevention and Control, and Antimicrobial Stewardship<br>3. Infections Associated With Group Childcare<br>4. Infectious Diseases in Refugee and Internationally Adopted Children<br>Section B. Prevention of Infectious Diseases<br>5. Passive Immunization<br>6. Active Immunization<br>7. Antimicrobial Chemoprophylaxis<br>8. Protection of Travelers<br>Section C. Host Defenses Against Infectious Diseases<br>9. Immunologic Development and Susceptibility to Infection<br>10. Fever and the Inflammatory Response<br><br>PART II: Clinical Syndromes and Cardinal Features of Infectious Diseases: Approach to Diagnosis and Initial Management<br>Section A. Septicemia, Toxin-, and Inflammation-Mediated Syndromes<br>11. The Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock<br>12. Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome<br>Section B. Cardinal Symptom Complexes<br>13. Mucocutaneous Symptom Complexes<br>14. Fever Without Localizing Signs<br>15. Prolonged, Recurrent, and Periodic Fever Syndromes<br>16. Lymphatic System and Generalized Lymphadenopathy<br>17. Cervical Lymphadenitis and Neck Infections<br>18. Mediastinal and Hilar Lymphadenopathy<br>19. Abdominal and Retroperitoneal Lymphadenopathy<br>20. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis<br>21. Respiratory Tract Symptom Complexes<br>22. Abdominal Symptom Complexes<br>23. Neurologic Syndromes<br>24. Musculoskeletal Symptom Complexes<br>Section C. Oral Infections and Upper and Middle Respiratory Tract Infections<br>25. Infections of the Oral Cavity<br>26. The Common Cold<br>27. Pharyngitis<br>28. Infections Related to the Upper and Middle Airways<br>29. Otitis Media<br>30. Otitis Externa and Necrotizing Otitis Externa<br>31. Mastoiditis<br>32. Sinusitis<br>Section D. Lower Respiratory Tract Infections<br>33. Bronchiolitis<br>34. Acute Pneumonia and Its Complications<br>35. Persistent and Recurrent Pneumonia<br>36. Pneumonia in the Immunocompromised Host<br>Section E. Cardiac and Vascular Infections<br>37. Endocarditis and Other Intravascular Infections<br>38. Myocarditis<br>39. Pericarditis<br>Section F. Central Nervous System Infections<br>40. Acute Bacterial Meningitis Beyond the Neonatal Period<br>41. Chronic Meningitis<br>42. Recurrent Meningitis<br>43. Aseptic and Viral Meningitis<br>44. Encephalitis<br>45. Parainfectious and Postinfectious Neurologic Syndromes<br>46. Focal Suppurative Infections of the Nervous System<br>47. Eosinophilic Meningitis<br>Section G. Genitourinary Tract Infections<br>48. Urinary Tract Infections, Renal Abscess, and Other Complex Renal Functions<br>49. Sexually Transmitted Infection Syndromes<br>50. Genitourinary Skin and Mucous Membrane Infections and Inguinal Lymphadenopathy<br>51. Urethritis, Vulvovaginitis, and Cervicitis<br>52. Pelvic Inflammatory Disease<br>53. Epididymitis, Orchitis, and Prostatitis<br>54. Infectious Diseases Associated With Child Abuse<br>Section H. Gastrointestinal and Tract Infections and Intoxications<br>55. Approach to the Diagnosis and Management of Gastrointestinal Tract Infections<br>56. Viral Gastroenteritis<br>57. Inflammatory Enterocolitis<br>58. Enteric Diseases Transmitted Through Food, Water, and Zoonotic Exposures<br>Section I. Intra-abdominal Infections<br>59. Acute Hepatitis<br>60. Chronic Hepatitis<br>61. Granulomatous Hepatitis<br>62. Acute Pancreatitis<br>63. Cholecystitis and Cholangitis<br>64. Peritonitis<br>65. Appendicitis<br>66. Intra-abdominal, Visceral, and Retroperitoneal Abscesses<br>Section J. Skin and Soft-Tissue Infections<br>67. Superficial Bacterial Skin Infections and Cellulitis<br>68. Erythematous Macules and Papules<br>69. Vesicles and Bullae<br>70. Purpura<br>71. Urticaria and Erythema Multiforme<br>72. Papules, Nodules, and Ulcers<br>73. Subcutaneous Tissue Infections and Abscesses<br>74. Myositis, Pyomyositis, and Necrotizing Fascitis<br>Section K. Bone and Joint Infections<br>75. Osteomyelitis<br>76. Infectious and Inflammatory Arthritis<br>77. Diskitis<br>78. Transient Synovitis<br>Section L. Eye Infections<br>79. Conjunctivitis in the Neonatal Period (Ophthalmia neonatorum)<br>80. Conjunctivitis Beyond the Neonatal Period<br>81. Infective Keratitis<br>82. Infective Uveitis, Retinitis, and Chorioretinitis<br>83. Endophthalmitis<br>84. Preseptal and Orbital Infections<br>Section M. Infections Related to Trauma, Animals, and Ticks<br>85. Infection Related To Trauma<br>86. Infections Related to Burns<br>87. Infection Related To Bites<br>88. Infections Related to Pets and Exotic Animals<br>89. Tickborne Infections<br>Section N. Infections of the Fetus and Newborn<br>90. Clinical Approach to the Neonate With Suspected Infection<br>91. Chorioamnionitis and Neonatal Consequences<br>92. Bacterial Infections in the Neonate<br>93. Viral Infections in the Fetus and Neonate<br>94. Healthcare-Associated Infections in the Neonate<br>Section O. Infections and Transplantation<br>95. Infections in Solid Organ Transplant Recipients<br>96. Infections in Hematopoietic Cell Transplant Recipients<br>Section P. Infections and Cancer<br>97. Risk Factors and Infectious Agents in Children With Cancer: Fever and Granulocytopenia<br>98. Clinical Syndromes of Infection in Children With Cancer<br>Section Q. Infections Associated With Hospitalization and Medical Devices<br>99. Healthcare-Associated Infections<br>100. Clinical Syndromes of Device-Associated Infections<br>Section R. Infections in Patients With Deficient Defenses<br>101. Evaluation of the Child With Suspected Immunodeficiency<br>102. Infectious Complications of Antibody Deficiency<br>103. Infectious Complications of Complement Deficiency and Diseases of Its Dysregulation<br>104. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes<br>105. Infectious Complications of Cell-Mediated Immunity Other Than AIDS: Primary Immunodeficiencies<br>106. Infectious Complications in Special Hosts<br>107. Infections Related to Biologic Response Modifying Drug Therapy<br>108. Infectious Complications of Corticosteroid Therapy<br>Section S. Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome<br>109. Epidemiology and Prevention of HIV Infection in Infants, Children, and Adolescents<br>110. Immunopathogenesis of HIV-1 Infection<br>111. Diagnosis and Clinical Manifestations of HIV Infection<br>112. Infectious Complications of HIV Infection<br>113. Management of HIV Infection<br><br>PART III: Etiologic Agents of Infectious Diseases<br>Section A. Bacteria<br>114. Classification of Bacteria<br>Gram-Positive Cocci<br>115. Staphylococcus aureus<br>116. Coagulase-Negative Staphylococci and Micrococcaceae<br>117. Classification of Streptococci<br>118. Streptococcus pyogenes (Group A Streptococcus)<br>119. Streptococcus agalactiae (Group B Streptococcus)<br>120. Enterococcus Species<br>121. Viridans Streptococci, Abiotrophia and Granulicatella Species, and Streptococcus bovis Group<br>122. Groups C and G Streptococci<br>123. Streptococcus pneumoniae<br>124. Other Gram-Positive, Catalase-Negative Cocci: Leuconostoc and Pediococcus Species and Other Genera<br>Gram-Negative Cocci<br>125. Neisseria meningitidis<br>126. Neisseria gonorrhoeae<br>127. Other Neisseria Species<br>Gram-Positive Bacilli<br>128. Arcanobacterium haemolyticum<br>129. Bacillus Species (Including Anthrax)<br>130. Corynebacterium diphtheriae<br>131. Other Corynebacteria<br>132. Listeria monocytogenes<br>133. Other Gram-Positive Bacilli<br>134. Mycobacterium tuberculosis<br>135. Mycobacterium Nontuberculosis Species<br>136. Nocardia Species<br>Enterobacteriaceae: Gram-Negative Bacilli<br>137. Escherichia coli<br>138. Klebsiella and Raoultella Species<br>139. Klebsiella granulomatis: Granuloma Inguinale (Donovanosis)<br>140. Enterobacter, Cronobacter, and Pantoea Species<br>141. Citrobacter Species<br>142. Less Commonly Encountered Enterobacterales<br>143. Plesiomonas shigelloides<br>144. Proteus, Providencia, and Morganella Species<br>145. Serratia Species<br>146. Salmonella Species<br>147. Shigella Species<br>148. Yersinia Species<br>Nonenterobacteriaceae: Gram-Negative Bacilli<br>149. Acinetobacter Species<br>150. Aeromonas Species<br>151. Less Commonly Encountered Nonenteric Gram-Negative Bacilli<br>152. Eikenella, Pasteurella, and Chromobacterium Species<br>153. Moraxella Species<br>154. Pseudomonas Species and Related Organisms<br>155. Pseudomonas aeruginosa<br>156. Burkholderia cepacia Complex and Other Burkholderia Species<br>157. Stenotrophomonas maltophilia<br>158. Vibrio cholerae (Cholera)<br>159. Other Vibrio Species<br>Gram-Negative Coccobacilli<br>160. Bartonella Species (Cat-Scratch Disease)<br>161. Brucella Species (Brucellosis)<br>162. Bordetella pertussis (Pertussis) and Other Bordetella Species<br>163. Campylobacter jejuni and Campylobacter coli<br>164. Other Campylobacter Species<br>165. Capnocytophaga Species<br>166. Chlamydophila (Chlamydia) pneumoniae<br>167. Chlamydia trachomatis<br>168. Chlamydia (Chlamydophila) psittaci (Psittacosis)<br>169. Coxiella burnetii (Q Fever)<br>170. Family Anaplasmataceae (Anaplasmosis, Ehrlichiosis, Neorickettsiosis, and Neoehrlichiosis)<br>171. Francisella tularensis (Tularemia)<br>172. Haemophilus influenzae<br>173. Other Haemophilus Species and Aggregatibacter Species<br>174. Helicobacter pylori<br>175. Other Gastric and Enterohepatic Helicobacter Species<br>176. Kingella Species<br>177. Legionella Species<br>178. Rickettsia rickettsii (Rocky Mountain Spotted Fever)<br>179. Other Rickettsia Species<br>180. Streptobacillus moniliformis (Rat-Bite Fever)<br>181. Other Gram-Negative Coccobacilli<br>Treponemataceae (Spiral Organisms)<br>182. Treponema pallidum (Syphilis)<br>183. Other Treponema Species<br>184. Leptospira Species (Leptospirosis)<br>185. Borrelia burgdorferi (Lyme Disease)<br>186. Other Borrelia Species and Spirillum minus<br>Anaerobic Bacteria<br>187. Anaerobic Bacteria: Clinical Concepts and the Microbiome in Health and Disease<br>188. Clostridium tetani (Tetanus)<br>189. Clostridium botulinum (Botulism)<br>190. Clostridioides difficile<br>191. Other Clostridium Species<br>192. Bacteroides and Prevotella Species and Other Anaerobic Gram-Negative Bacilli<br>193. Fusobacterium Species<br>194. Anaerobic Cocci<br>195. Anaerobic Gram-Positive Nonsporulating Bacilli (Including Actinomycosis)<br>Mycoplasma<br>196. Mycoplasma pneumoniae<br>197. Other Mycoplasma Species<br>198. Ureaplasma urealyticum<br>Diseases of Possible Infectious or Unknown Etiology<br>199. Kawasaki Disease<br>200. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<br>Section B. Viruses<br>201. Classification of Human Viruses<br>DNA Viruses: Poxviridae<br>202. Poxviridae<br>DNA Viruses: Herpesviridae<br>203. Introduction to Herpesviridae<br>204. Herpes Simplex Virus<br>205. Varicella-Zoster Virus<br>206. Cytomegalovirus<br>207. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum)<br>208. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)<br>209. Human Herpesvirus 8 (Kaposi Sarcoma–Associated Herpesvirus)<br>DNA Viruses: Adenoviridae<br>210. Adenoviruses<br>DNA Viruses: Papovaviridae<br>211. Human Papillomavirus<br>212. BK, JC, and Other Human Polyomaviruses<br>DNA Viruses: Hepadnaviridae<br>213. Hepatitis B and Hepatitis D Viruses<br>DNA Viruses: Parvoviridae<br>214. Human Parvoviruses (Parvovirus B19 and Bocavirus)<br>RNA Viruses: Reoviridae<br>215. Coltivirus (Colorado Tick Fever)<br>216. Rotaviruses<br>RNA Viruses: Togaviridae, Flaviviridae, and Bunyaviridae<br>217. Togaviridae: Alphaviruses<br>218. Flaviviruses<br>219. Bunyaviruses<br>220. Hepatitis C Virus<br>221. Rubella Virus<br>RNA Viruses: Coronaviridae<br>222. Human Coronaviruses<br>RNA Viruses: Paramyxoviridae<br>223. Parainfluenza Viruses<br>224. Mumps Virus<br>225. Respiratory Syncytial Virus<br>226. Human Metapneumovirus<br>227. Rubeola Virus: Measles and Subacute Sclerosing Panencephalitis<br>RNA Viruses: Rhabdoviridae<br>228. Rabies Virus<br>RNA Viruses: Orthomyxoviridae<br>229. Influenza Viruses<br>RNA Viruses: Arenaviridae and Filoviridae<br>230. Filoviruses and Arenaviruses<br>RNA Viruses: Retroviridae<br>231. Introduction to Retroviridae<br>232. Human T-Cell Lymphotropic Viruses<br>233. Human Immunodeficiency Virus<br>RNA Viruses: Picornaviridae<br>234. Introduction to Picornaviridae<br>235. Polioviruses<br>236. Enteroviruses and Parechoviruses<br>237. Hepatitis A Virus<br>238. Rhinoviruses<br>RNA Viruses: Caliciviridae<br>239. Caliciviruses<br>240. Astroviruses<br>241. Hepatitis E Virus<br>Section C. Fungi<br>242. Classification of Fungi<br>243. Candida Species<br>244. Aspergillus Species<br>245. Agents of Hyalohyphomycosis and Phaeohyphomycosis<br>246. Agents of Mucormycosis<br>247. Malassezia Species<br>248. Sporothrix schenckii Complex (Sporotrichosis)<br>249. Cryptococcus Species<br>250. Histoplasma capsulatum (Histoplasmosis)<br>251. Pneumocystis jirovecii<br>252. Blastomyces Species (Blastomycosis)<br>253. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis)<br>254. Superficial Fungal Infections<br>255. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum<br>Section D. Human Parasites and Vectors<br>256. Classification of Parasites<br>257. Ectoparasites (Lice and Scabies)<br>Protozoa<br>258. Babesia Species (Babesiosis)<br>259. Balantioides coli (Formerly Balantidium coli)<br>260. Blastocystis Species<br>261. Cryptosporidium Species<br>262. Endolimax nana<br>263. Entamoeba histolytica (Amebiasis)<br>264. Other Entamoeba, Amebae, and Intestinal Flagellates<br>265. Giardia intestinalis (Giardiasis)<br>266. Cystoisospora (Isospora) and Cyclospora Species<br>267. Leishmania Species (Leishmaniasis)<br>268. Microsporidia<br>269. Naegleria fowleri<br>270. Acanthamoeba Species<br>271. Plasmodium Species (Malaria)<br>272. Sarcocystis Species<br>273. Toxoplasma gondii (Toxoplasmosis)<br>274. Trichomonas vaginalis<br>275. Trypanosoma Species (Trypanosomiasis)<br>Nematodes<br>276. Intestinal Nematodes<br>277. Tissue Nematodes<br>278. Blood and Tissue Nematodes: Filarial Worms<br>Cestodes<br>279. Diphyllobothriidae, Dipylidium and Hymenolepis Species<br>280. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis<br>281. Echinococcus Species: Agents of Echinococcosis<br>282. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis<br>Trematodes<br>283. Intestinal Trematodes<br>284. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species<br>285. Blood Trematodes: Schistosomiasis<br><br>PART IV: Laboratory Diagnosis and Therapy for Infectious Diseases<br>Section A. The Clinician and the Laboratory<br>286. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae<br>287. Laboratory Diagnosis of Infection Due to Viruses, Chlamydia, and Mycoplasma<br>288. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases<br>Section B. Anti-Infective Therapy<br>289. Principles of Anti-Infective Therapy<br>290. Mechanisms and Detection of Antimicrobial Resistance<br>291. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy<br>292. Antibacterial Agents<br>293. Antifungal Agents<br>294. Topical Antimicrobial Agents<br>295. Antiviral Agents<br>296. Antiparasitic Agents</p>